SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dgt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3dgt ENDO-1,3-BETA-GLUCAN
ASE
(Streptomyces
sioyaensis) 		4 / 7 LEU A 100
PHE A 123
VAL A 210
SER A 209
 None
 1.11A 1wrlA-3dgtA:
undetectable
1wrlB-3dgtA:
undetectable		 1wrlA-3dgtA:
14.70
1wrlB-3dgtA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 3dgt ENDO-1,3-BETA-GLUCAN
ASE
(Streptomyces
sioyaensis) 		5 / 12 TRP A 197
GLY A 141
GLY A 127
LEU A 143
TRP A 228
 None
 0.98A 1xdsA-3dgtA:
undetectable		 1xdsA-3dgtA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3dgt ENDO-1,3-BETA-GLUCAN
ASE
(Streptomyces
sioyaensis) 		3 / 3 ASP A 269
ASP A  15
ASN A  65
 MG  A 800 (-3.1A)
None
None
 0.85A 2bm9D-3dgtA:
undetectable		 2bm9D-3dgtA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 3dgt ENDO-1,3-BETA-GLUCAN
ASE
(Streptomyces
sioyaensis) 		5 / 12 MET A 159
ILE A 206
LEU A 143
ASN A 136
ALA A 220
 None
 1.06A 3a50D-3dgtA:
undetectable		 3a50D-3dgtA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3dgt ENDO-1,3-BETA-GLUCAN
ASE
(Streptomyces
sioyaensis) 		4 / 6 HIS A 264
ALA A 116
GLY A 118
TYR A 119
 None
 1.15A 3ddwB-3dgtA:
undetectable		 3ddwB-3dgtA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 3dgt ENDO-1,3-BETA-GLUCAN
ASE
(Streptomyces
sioyaensis) 		4 / 7 TRP A 137
GLU A 142
ASP A 144
THR A  47
 None
 1.34A 3dzgB-3dgtA:
undetectable		 3dzgB-3dgtA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3dgt ENDO-1,3-BETA-GLUCAN
ASE
(Streptomyces
sioyaensis) 		4 / 7 MET A 146
GLU A 147
GLU A  49
ARG A  84
 None
 1.43A 4r87J-3dgtA:
undetectable
4r87L-3dgtA:
undetectable		 4r87J-3dgtA:
17.44
4r87L-3dgtA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3dgt ENDO-1,3-BETA-GLUCAN
ASE
(Streptomyces
sioyaensis) 		3 / 3 ASP A 269
GLY A  66
ASP A  63
 MG  A 800 (-3.1A)
MG  A 800 (-3.7A)
None
 0.65A 4xdtA-3dgtA:
undetectable		 4xdtA-3dgtA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 3dgt ENDO-1,3-BETA-GLUCAN
ASE
(Streptomyces
sioyaensis) 		4 / 5 LEU A 126
GLU A 147
MET A 159
HIS A 234
 None
 1.19A 4xi3B-3dgtA:
undetectable		 4xi3B-3dgtA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 3dgt ENDO-1,3-BETA-GLUCAN
ASE
(Streptomyces
sioyaensis) 		3 / 5 GLY A 141
GLY A 162
GLU A 171
 None
 0.52A 4z2eA-3dgtA:
undetectable
4z2eD-3dgtA:
undetectable		 4z2eA-3dgtA:
18.35
4z2eD-3dgtA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 3dgt ENDO-1,3-BETA-GLUCAN
ASE
(Streptomyces
sioyaensis) 		3 / 3 ARG A 101
LYS A  99
GLU A 196
 None
 0.83A 5d0yA-3dgtA:
undetectable		 5d0yA-3dgtA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 3dgt ENDO-1,3-BETA-GLUCAN
ASE
(Streptomyces
sioyaensis) 		5 / 12 PHE A  13
VAL A 102
ILE A  85
VAL A  25
VAL A 238
 None
 1.33A 6ap6A-3dgtA:
undetectable		 6ap6A-3dgtA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 3dgt ENDO-1,3-BETA-GLUCAN
ASE
(Streptomyces
sioyaensis) 		5 / 12 PHE A  13
VAL A 102
ILE A  85
VAL A  25
VAL A 238
 None
 1.34A 6ap6B-3dgtA:
undetectable		 6ap6B-3dgtA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_A_GM4A301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3dgt ENDO-1,3-BETA-GLUCAN
ASE
(Streptomyces
sioyaensis) 		5 / 11 LEU A 126
ASP A 144
TRP A 120
GLU A 142
ALA A  42
 None
 1.24A 6dk1A-3dgtA:
0.1		 6dk1A-3dgtA:
20.69