SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dgz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 3dgz THIOREDOXIN
REDUCTASE 2
(Mus
musculus) 		5 / 9 GLY A  57
GLY A 157
GLY A 156
ASP A 326
ARG A 285
 FAD  A 500 (-3.5A)
None
FAD  A 500 (-3.4A)
FAD  A 500 (-3.0A)
FAD  A 500 ( 3.7A)
 1.05A 1mxdA-3dgzA:
undetectable		 1mxdA-3dgzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 3dgz THIOREDOXIN
REDUCTASE 2
(Mus
musculus) 		5 / 11 GLY A  57
GLY A 157
GLY A 156
ASP A 326
ARG A 285
 FAD  A 500 (-3.5A)
None
FAD  A 500 (-3.4A)
FAD  A 500 (-3.0A)
FAD  A 500 ( 3.7A)
 1.03A 1mxgA-3dgzA:
undetectable		 1mxgA-3dgzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 3dgz THIOREDOXIN
REDUCTASE 2
(Mus
musculus) 		4 / 6 GLY A 172
ILE A 173
PRO A 159
ILE A 283
 None
None
None
NA7  A 501 (-3.5A)
 0.81A 1n49D-3dgzA:
undetectable		 1n49D-3dgzA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 3dgz THIOREDOXIN
REDUCTASE 2
(Mus
musculus) 		3 / 3 LYS A 307
ARG A 285
VAL A 286
 NA7  A 501 ( 4.8A)
FAD  A 500 ( 3.7A)
None
 1.10A 2r2vC-3dgzA:
undetectable
2r2vD-3dgzA:
undetectable		 2r2vC-3dgzA:
4.80
2r2vD-3dgzA:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 3dgz THIOREDOXIN
REDUCTASE 2
(Mus
musculus) 		4 / 8 MET A 227
SER A 378
TYR A 372
HIS A 431
 None
 1.23A 2v0gA-3dgzA:
undetectable		 2v0gA-3dgzA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3dgz THIOREDOXIN
REDUCTASE 2
(Mus
musculus) 		5 / 12 THR A 335
GLY A  14
GLY A  18
LEU A  49
ASN A 107
 FAD  A 500 (-4.5A)
FAD  A 500 ( 4.7A)
None
None
None
 1.20A 2zw9B-3dgzA:
undetectable		 2zw9B-3dgzA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3dgz THIOREDOXIN
REDUCTASE 2
(Mus
musculus) 		3 / 3 GLY A 172
PRO A  42
LEU A 169
 None
 0.63A 3hcpB-3dgzA:
undetectable		 3hcpB-3dgzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 3dgz THIOREDOXIN
REDUCTASE 2
(Mus
musculus) 		4 / 4 ILE A 153
ARG A 135
ILE A  12
THR A 316
 None
 0.79A 3ia4C-3dgzA:
undetectable		 3ia4C-3dgzA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 3dgz THIOREDOXIN
REDUCTASE 2
(Mus
musculus) 		3 / 3 ARG A 135
ILE A  12
THR A 316
 None
 0.71A 3ia4D-3dgzA:
undetectable		 3ia4D-3dgzA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 3dgz THIOREDOXIN
REDUCTASE 2
(Mus
musculus) 		5 / 11 VAL A 261
LEU A 189
VAL A 165
GLY A 167
ALA A 168
 None
 1.13A 3pghB-3dgzA:
undetectable		 3pghB-3dgzA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 3dgz THIOREDOXIN
REDUCTASE 2
(Mus
musculus) 		4 / 7 ARG A 117
GLY A  13
VAL A 119
VAL A  32
 None
FAD  A 500 (-3.1A)
None
None
 0.84A 3ufnB-3dgzA:
undetectable		 3ufnB-3dgzA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3dgz THIOREDOXIN
REDUCTASE 2
(Mus
musculus) 		5 / 12 ALA A 452
SER A 453
VAL A 457
THR A 441
PHE A 444
 None
 1.28A 4c49A-3dgzA:
undetectable		 4c49A-3dgzA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 3dgz THIOREDOXIN
REDUCTASE 2
(Mus
musculus) 		4 / 7 PHE A 242
VAL A 190
GLY A 202
THR A 368
 None
 1.01A 4ejjB-3dgzA:
undetectable		 4ejjB-3dgzA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3dgz THIOREDOXIN
REDUCTASE 2
(Mus
musculus) 		5 / 11 GLY A 429
GLY A 376
LEU A 377
GLU A 381
HIS A 431
 None
 1.10A 4l8fB-3dgzA:
undetectable		 4l8fB-3dgzA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3dgz THIOREDOXIN
REDUCTASE 2
(Mus
musculus) 		5 / 11 GLY A 429
GLY A 376
LEU A 377
GLU A 381
HIS A 431
 None
 1.12A 4l8fD-3dgzA:
undetectable		 4l8fD-3dgzA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 3dgz THIOREDOXIN
REDUCTASE 2
(Mus
musculus) 		5 / 8 ALA A 154
VAL A  11
GLY A  17
ALA A 338
GLY A 342
 FAD  A 500 (-4.2A)
None
FAD  A 500 (-3.4A)
FAD  A 500 ( 4.0A)
None
 1.23A 4zjzB-3dgzA:
undetectable		 4zjzB-3dgzA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 3dgz THIOREDOXIN
REDUCTASE 2
(Mus
musculus) 		5 / 8 ALA A 154
VAL A 152
GLY A  17
ALA A 338
GLY A 342
 FAD  A 500 (-4.2A)
None
FAD  A 500 (-3.4A)
FAD  A 500 ( 4.0A)
None
 1.29A 4zjzB-3dgzA:
undetectable		 4zjzB-3dgzA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3dgz THIOREDOXIN
REDUCTASE 2
(Mus
musculus) 		4 / 8 THR A 240
PRO A 369
PRO A 185
LEU A 209
 None
 0.71A 5g48A-3dgzA:
undetectable		 5g48A-3dgzA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3dgz THIOREDOXIN
REDUCTASE 2
(Mus
musculus) 		3 / 3 VAL A 279
HIS A 250
VAL A 165
 None
 0.72A 5jmnC-3dgzA:
undetectable		 5jmnC-3dgzA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 3dgz THIOREDOXIN
REDUCTASE 2
(Mus
musculus) 		4 / 8 ARG A 158
GLY A  13
ASP A  36
TRP A  47
 None
FAD  A 500 (-3.1A)
FAD  A 500 (-2.8A)
None
 1.12A 5kf8A-3dgzA:
undetectable		 5kf8A-3dgzA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 3dgz THIOREDOXIN
REDUCTASE 2
(Mus
musculus) 		4 / 8 ARG A 158
GLY A  13
ASP A  36
TRP A  47
 None
FAD  A 500 (-3.1A)
FAD  A 500 (-2.8A)
None
 1.10A 5kgpA-3dgzA:
undetectable		 5kgpA-3dgzA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 3dgz THIOREDOXIN
REDUCTASE 2
(Mus
musculus) 		4 / 8 ARG A 158
GLY A  13
ASP A  36
TRP A  47
 None
FAD  A 500 (-3.1A)
FAD  A 500 (-2.8A)
None
 1.08A 5kgpB-3dgzA:
undetectable		 5kgpB-3dgzA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3dgz THIOREDOXIN
REDUCTASE 2
(Mus
musculus) 		5 / 12 LEU A 280
ILE A 173
GLY A 172
LEU A 204
LEU A 209
 None
 0.99A 5nfjA-3dgzA:
2.6		 5nfjA-3dgzA:
17.32