SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dh0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 3dh0 SAM DEPENDENT
METHYLTRANSFERASE
(Aquifex
aeolicus) 		4 / 7 LEU A  21
SER A  19
ASP A  17
PHE A  24
 None
 1.22A 1ismB-3dh0A:
undetectable		 1ismB-3dh0A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 3dh0 SAM DEPENDENT
METHYLTRANSFERASE
(Aquifex
aeolicus) 		4 / 4 ASP A  43
LEU A  15
GLY A  47
ARG A  20
 None
SAM  A 220 (-4.0A)
SAM  A 220 ( 3.7A)
SAM  A 220 (-2.9A)
 1.32A 2j2pD-3dh0A:
undetectable
2j2pE-3dh0A:
undetectable		 2j2pD-3dh0A:
17.11
2j2pE-3dh0A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 3dh0 SAM DEPENDENT
METHYLTRANSFERASE
(Aquifex
aeolicus) 		4 / 6 ALA A 171
ASP A 170
GLU A 127
MET A 112
 None
 1.37A 2ouzA-3dh0A:
undetectable		 2ouzA-3dh0A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3dh0 SAM DEPENDENT
METHYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 ILE A 167
ILE A  68
ILE A 110
LEU A 139
VAL A 132
 None
 0.99A 2qo5A-3dh0A:
undetectable		 2qo5A-3dh0A:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3dh0 SAM DEPENDENT
METHYLTRANSFERASE
(Aquifex
aeolicus) 		12 / 12 PHE A   7
LEU A  15
VAL A  44
GLY A  45
GLY A  47
PHE A  50
VAL A  70
SER A  95
ALA A 113
PHE A 114
THR A 115
LEU A 119
 None
SAM  A 220 (-4.0A)
SAM  A 220 ( 4.8A)
SAM  A 220 (-3.5A)
SAM  A 220 ( 3.7A)
None
SAM  A 220 ( 4.1A)
SAM  A 220 ( 3.7A)
SAM  A 220 (-3.9A)
None
SAM  A 220 (-4.1A)
SAM  A 220 (-4.6A)
 0.03A 3dh0A-3dh0A:
39.9		 3dh0A-3dh0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3dh0 SAM DEPENDENT
METHYLTRANSFERASE
(Aquifex
aeolicus) 		8 / 8 LYS A   6
ARG A  20
TYR A  51
ASP A  69
GLN A  71
MET A  74
GLU A  97
GLU A 118
 SAM  A 220 (-2.9A)
SAM  A 220 (-2.9A)
SAM  A 220 (-3.8A)
SAM  A 220 (-3.0A)
SAM  A 220 (-4.1A)
SAM  A 220 (-4.2A)
SAM  A 220 (-3.2A)
SAM  A 220 (-3.3A)
 0.01A 3dh0A-3dh0A:
39.9		 3dh0A-3dh0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3dh0 SAM DEPENDENT
METHYLTRANSFERASE
(Aquifex
aeolicus) 		12 / 12 PHE A   7
LEU A  15
ARG A  20
GLY A  45
GLY A  47
PHE A  50
VAL A  70
GLN A  71
MET A  74
ALA A 113
THR A 115
LEU A 119
 None
SAM  A 220 (-4.0A)
SAM  A 220 (-2.9A)
SAM  A 220 (-3.5A)
SAM  A 220 ( 3.7A)
None
SAM  A 220 ( 4.1A)
SAM  A 220 (-4.1A)
SAM  A 220 (-4.2A)
SAM  A 220 (-3.9A)
SAM  A 220 (-4.1A)
SAM  A 220 (-4.6A)
 0.30A 3dh0B-3dh0A:
36.6		 3dh0B-3dh0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DH0_B_SAMB300_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3dh0 SAM DEPENDENT
METHYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 5 LYS A   6
TYR A  51
ASP A  69
GLU A  97
GLU A 118
 SAM  A 220 (-2.9A)
SAM  A 220 (-3.8A)
SAM  A 220 (-3.0A)
SAM  A 220 (-3.2A)
SAM  A 220 (-3.3A)
 0.42A 3dh0B-3dh0A:
36.6		 3dh0B-3dh0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3dh0 SAM DEPENDENT
METHYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 11 GLY A  45
GLY A  47
ILE A  68
VAL A  70
PHE A 114
 SAM  A 220 (-3.5A)
SAM  A 220 ( 3.7A)
None
SAM  A 220 ( 4.1A)
None
 0.67A 3dxyA-3dh0A:
13.1		 3dxyA-3dh0A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3dh0 SAM DEPENDENT
METHYLTRANSFERASE
(Aquifex
aeolicus) 		4 / 8 ILE A 141
ASN A  98
VAL A  44
GLY A  45
 None
None
SAM  A 220 ( 4.8A)
SAM  A 220 (-3.5A)
 0.89A 3em0B-3dh0A:
undetectable		 3em0B-3dh0A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 3dh0 SAM DEPENDENT
METHYLTRANSFERASE
(Aquifex
aeolicus) 		3 / 3 ARG A 131
ILE A 110
THR A  46
 None
 0.75A 3ia4D-3dh0A:
2.3		 3ia4D-3dh0A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 3dh0 SAM DEPENDENT
METHYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 9 GLY A 172
ALA A 171
ASP A 170
GLY A 165
ILE A 110
 None
 1.01A 3s53A-3dh0A:
undetectable		 3s53A-3dh0A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 3dh0 SAM DEPENDENT
METHYLTRANSFERASE
(Aquifex
aeolicus) 		3 / 3 VAL A  82
GLY A  86
LYS A  88
 None
 0.75A 4k50A-3dh0A:
undetectable		 4k50A-3dh0A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 3dh0 SAM DEPENDENT
METHYLTRANSFERASE
(Aquifex
aeolicus) 		3 / 3 VAL A  82
GLY A  86
LYS A  88
 None
 0.72A 4k50E-3dh0A:
undetectable		 4k50E-3dh0A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 3dh0 SAM DEPENDENT
METHYLTRANSFERASE
(Aquifex
aeolicus) 		4 / 7 ASN A  89
VAL A  65
ALA A  67
GLY A  49
 None
 0.80A 5fpdA-3dh0A:
undetectable		 5fpdA-3dh0A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 3dh0 SAM DEPENDENT
METHYLTRANSFERASE
(Aquifex
aeolicus) 		4 / 7 ASN A  89
VAL A  65
ALA A  67
GLY A  49
 None
 0.81A 5fpdB-3dh0A:
undetectable		 5fpdB-3dh0A:
19.58