SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dh3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3dh3 RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE F
(Escherichia
coli) 		5 / 10 SER A 110
GLY A  77
GLU A 204
GLY A 112
ARG A 205
 None
 1.30A 1mehA-3dh3A:
undetectable		 1mehA-3dh3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3dh3 RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE F
(Escherichia
coli) 		4 / 6 PHE A 177
VAL A 139
LEU A 203
PHE A 149
 None
 0.96A 1wrlB-3dh3A:
undetectable		 1wrlB-3dh3A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 3dh3 RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE F
(Escherichia
coli) 		5 / 10 VAL A  52
ALA A  40
ILE A  42
ASP A  44
ILE A  13
 None
None
G  E2597 ( 4.6A)
None
None
 1.23A 3clbD-3dh3A:
undetectable		 3clbD-3dh3A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 3dh3 RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE F
(Escherichia
coli) 		5 / 9 ASP A 107
GLY A 112
LEU A 113
VAL A  94
ILE A  90
 U  E2605 ( 4.3A)
None
None
None
None
 1.10A 3em4B-3dh3A:
undetectable		 3em4B-3dh3A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3dh3 RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE F
(Escherichia
coli) 		5 / 9 GLU A 228
VAL A 211
ILE A 126
PHE A 115
THR A 225
 None
 1.33A 3fl9H-3dh3A:
undetectable		 3fl9H-3dh3A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dh3 RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE F
(Escherichia
coli) 		5 / 10 VAL A  52
ALA A  40
ILE A  42
ASP A  44
ILE A  13
 None
None
G  E2597 ( 4.6A)
None
None
 1.23A 3hbbD-3dh3A:
undetectable		 3hbbD-3dh3A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 3dh3 RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE F
(Escherichia
coli) 		5 / 11 GLU A 228
VAL A 211
ILE A 126
PHE A 115
THR A 225
 None
 1.31A 3jw5A-3dh3A:
undetectable		 3jw5A-3dh3A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3dh3 RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE F
(Escherichia
coli) 		3 / 3 ASP A  25
ARG A  21
ALA A  24
 G  E2597 ( 2.6A)
C  E2594 ( 2.9A)
None
 0.66A 3mbgC-3dh3A:
undetectable		 3mbgC-3dh3A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 3dh3 RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE F
(Escherichia
coli) 		3 / 3 ASP A 142
GLU A 194
GLY A 197
 None
 0.67A 3w9tA-3dh3A:
undetectable		 3w9tA-3dh3A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3dh3 RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE F
(Escherichia
coli) 		5 / 12 GLY A 104
PRO A 102
LEU A 116
ARG A 207
LEU A 113
 G  E2603 ( 3.6A)
None
None
None
None
 1.10A 4x61A-3dh3A:
undetectable		 4x61A-3dh3A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3dh3 RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE F
(Escherichia
coli) 		4 / 7 VAL A  91
PRO A 102
ILE A 103
THR A  82
 None
None
None
C  E2591 ( 3.1A)
 0.96A 5vkqA-3dh3A:
undetectable
5vkqD-3dh3A:
undetectable		 5vkqA-3dh3A:
11.07
5vkqD-3dh3A:
11.07