SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dh4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		4 / 7 GLY A  48
ALA A  55
THR A 274
SER A  59
 None
 0.92A 1c9sT-3dh4A:
undetectable
1c9sU-3dh4A:
undetectable		 1c9sT-3dh4A:
10.00
1c9sU-3dh4A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		4 / 8 ALA A 170
LEU A 147
LEU A 407
ALA A 410
 None
 0.76A 1e7cA-3dh4A:
2.8		 1e7cA-3dh4A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		5 / 9 MET A 163
ALA A 170
LEU A 407
LEU A 143
ILE A 413
 None
 1.49A 1ereA-3dh4A:
undetectable		 1ereA-3dh4A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		4 / 5 ASP A 189
SER A  59
ASN A  64
SER A 368
 None
None
GAL  A 701 (-3.9A)
None
 1.40A 1kiaB-3dh4A:
undetectable		 1kiaB-3dh4A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		4 / 6 ASP A 189
SER A  59
ASN A  64
SER A 368
 None
None
GAL  A 701 (-3.9A)
None
 1.40A 1kiaC-3dh4A:
undetectable		 1kiaC-3dh4A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		5 / 12 ILE A 287
ALA A 291
ASN A 525
LEU A  95
ALA A  92
 None
 1.07A 1xdkA-3dh4A:
undetectable		 1xdkA-3dh4A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		5 / 12 VAL A 251
SER A  86
TYR A  87
ILE A  84
LEU A 256
 None
None
GAL  A 701 (-4.8A)
None
None
 1.25A 1z9hA-3dh4A:
3.0		 1z9hA-3dh4A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		5 / 12 VAL A 251
SER A  86
TYR A  87
ILE A  84
LEU A 256
 None
None
GAL  A 701 (-4.8A)
None
None
 1.25A 1z9hB-3dh4A:
3.3		 1z9hB-3dh4A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		5 / 12 VAL A 251
SER A  86
TYR A  87
ILE A  84
LEU A 256
 None
None
GAL  A 701 (-4.8A)
None
None
 1.26A 1z9hC-3dh4A:
3.3		 1z9hC-3dh4A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		4 / 8 PHE A 232
GLY A 220
VAL A 310
ILE A 306
 None
 0.69A 2a1mB-3dh4A:
undetectable		 2a1mB-3dh4A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		4 / 8 MET A 202
LEU A 198
VAL A 348
GLY A 349
 None
 0.91A 2qd5B-3dh4A:
undetectable		 2qd5B-3dh4A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		4 / 8 ASP A 336
LEU A 152
GLY A 418
TYR A 148
 None
 1.05A 3af0A-3dh4A:
undetectable		 3af0A-3dh4A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		4 / 5 SER A  66
LEU A 147
GLY A 150
GLU A  68
 None
 1.20A 3aiaA-3dh4A:
undetectable
3aiaB-3dh4A:
undetectable		 3aiaA-3dh4A:
19.87
3aiaB-3dh4A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		3 / 3 GLY A  81
GLY A 305
GLY A  77
 None
 0.35A 3bogC-3dh4A:
undetectable		 3bogC-3dh4A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		3 / 3 GLY A  81
GLY A 305
GLY A  77
 None
 0.33A 3bogD-3dh4A:
undetectable		 3bogD-3dh4A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		4 / 4 VAL A 460
ARG A 121
ILE A 114
THR A 490
 None
 1.41A 3cl9A-3dh4A:
undetectable		 3cl9A-3dh4A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		5 / 12 ILE A 287
ALA A 291
ASN A 525
LEU A  95
ALA A  92
 None
 0.93A 3dzyA-3dh4A:
undetectable		 3dzyA-3dh4A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		5 / 12 GLY A 305
SER A  74
SER A  79
ILE A 311
LEU A 342
 None
 1.22A 3iv6D-3dh4A:
undetectable		 3iv6D-3dh4A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		5 / 12 GLY A  75
VAL A 302
VAL A 301
GLY A  81
ILE A  80
 None
 1.00A 3ku1H-3dh4A:
undetectable		 3ku1H-3dh4A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		4 / 6 GLU A 233
ILE A 235
ALA A  83
ASN A 240
 None
 1.13A 3pgyA-3dh4A:
undetectable
3pgyB-3dh4A:
undetectable		 3pgyA-3dh4A:
21.89
3pgyB-3dh4A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		4 / 8 TYR A 269
LEU A 137
TYR A 262
TYR A 263
 None
None
None
GAL  A 701 ( 4.1A)
 1.34A 3po7A-3dh4A:
undetectable		 3po7A-3dh4A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		3 / 3 PHE A  70
VAL A 301
GLU A  88
 None
None
GAL  A 701 (-3.1A)
 0.80A 4fvqA-3dh4A:
undetectable		 4fvqA-3dh4A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		4 / 8 MET A 379
THR A 378
ALA A 374
LEU A 370
 None
 0.88A 4iizB-3dh4A:
undetectable		 4iizB-3dh4A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		5 / 11 MET A 163
LEU A 169
ALA A 170
LEU A 407
ILE A 413
 None
 1.22A 4pxmB-3dh4A:
undetectable		 4pxmB-3dh4A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		5 / 12 CYH A 411
LEU A 412
LEU A 147
ALA A 414
ALA A 170
 None
 1.22A 4x1kA-3dh4A:
undetectable
4x1kB-3dh4A:
undetectable		 4x1kA-3dh4A:
22.09
4x1kB-3dh4A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		3 / 3 VAL A 297
SER A  91
MET A 532
 None
GAL  A 701 (-2.5A)
None
 0.77A 5ikqA-3dh4A:
0.0		 5ikqA-3dh4A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		5 / 12 ILE A  97
THR A 514
ALA A 528
ILE A 271
PHE A 106
 None
 1.37A 5iwuA-3dh4A:
undetectable		 5iwuA-3dh4A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		4 / 7 VAL A 302
ASN A  64
ILE A  61
VAL A 297
 None
GAL  A 701 (-3.9A)
None
None
 1.00A 5jh7C-3dh4A:
undetectable		 5jh7C-3dh4A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		4 / 8 SER A 463
THR A 490
THR A 486
ILE A 438
 None
 0.66A 5jhdE-3dh4A:
undetectable
5jhdG-3dh4A:
undetectable		 5jhdE-3dh4A:
20.49
5jhdG-3dh4A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		4 / 6 VAL A 460
VAL A 132
ILE A 139
PHE A 140
 None
 0.87A 5jw1B-3dh4A:
undetectable		 5jw1B-3dh4A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		4 / 7 ILE A  61
LEU A  60
ILE A 531
ALA A 283
 None
 0.79A 6b5vA-3dh4A:
0.8
6b5vC-3dh4A:
0.0		 6b5vA-3dh4A:
8.83
6b5vC-3dh4A:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		4 / 7 ALA A 283
ILE A  61
LEU A  60
ILE A 531
 None
 0.78A 6b5vA-3dh4A:
0.8
6b5vB-3dh4A:
2.4		 6b5vA-3dh4A:
8.83
6b5vB-3dh4A:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		4 / 7 ILE A  61
LEU A  60
ILE A 531
ALA A 283
 None
 0.79A 6b5vC-3dh4A:
0.0
6b5vD-3dh4A:
0.1		 6b5vC-3dh4A:
8.83
6b5vD-3dh4A:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		4 / 7 ALA A 283
ILE A  61
LEU A  60
ILE A 531
 None
 0.80A 6b5vB-3dh4A:
2.4
6b5vD-3dh4A:
0.1		 6b5vB-3dh4A:
8.83
6b5vD-3dh4A:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		3 / 3 ALA A 259
PHE A 479
GLN A 425
 GAL  A 701 ( 4.0A)
None
None
 0.82A 6eceA-3dh4A:
undetectable		 6eceA-3dh4A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3dh4 SODIUM/GLUCOSE
COTRANSPORTER
(Vibrio
parahaemolyticus) 		5 / 12 LEU A 303
PRO A 298
ILE A 306
GLY A  77
ILE A  84
 None
 1.01A 6emuA-3dh4A:
undetectable		 6emuA-3dh4A:
16.60