SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dh9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		4 / 7 VAL A  53
VAL A  14
ARG A 119
LEU A  12
 None
 0.91A 1iepB-3dh9A:
undetectable		 1iepB-3dh9A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		5 / 11 GLY A 130
ARG A 147
ILE A 149
LEU A 138
GLY A 145
 FAD  A 500 (-4.0A)
None
None
None
None
 1.12A 1jg3B-3dh9A:
2.3		 1jg3B-3dh9A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		4 / 6 GLY A 174
ILE A 175
PRO A 162
ILE A 285
 None
 0.82A 1n49D-3dh9A:
undetectable		 1n49D-3dh9A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		5 / 12 GLY A 325
ALA A 338
ALA A 323
ASP A 326
ILE A 327
 FAD  A 500 (-3.4A)
FAD  A 500 ( 3.8A)
None
FAD  A 500 (-3.1A)
None
 1.16A 1nt2A-3dh9A:
3.1		 1nt2A-3dh9A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		5 / 12 ALA A 284
LEU A 282
LEU A 191
ILE A 242
GLY A 204
 None
 0.95A 1qknA-3dh9A:
undetectable		 1qknA-3dh9A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		5 / 12 GLY A  21
GLY A 342
ASP A  39
LEU A 138
VAL A 324
 None
None
FAD  A 500 (-3.1A)
None
None
 1.08A 2hmyB-3dh9A:
undetectable		 2hmyB-3dh9A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		4 / 8 MET A 229
SER A 378
TYR A 372
HIS A 431
 None
 1.23A 2v0gA-3dh9A:
undetectable		 2v0gA-3dh9A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		5 / 12 ILE A  15
ILE A 327
ALA A 323
THR A 316
LEU A 296
 FAD  A 500 (-4.8A)
None
None
None
None
 1.15A 3a50A-3dh9A:
undetectable		 3a50A-3dh9A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		4 / 7 VAL A 155
ILE A 327
GLY A 289
ARG A 161
 None
 0.83A 3bjwB-3dh9A:
undetectable		 3bjwB-3dh9A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		4 / 7 VAL A 155
ILE A 327
GLY A 289
ARG A 161
 None
 0.81A 3bjwF-3dh9A:
undetectable		 3bjwF-3dh9A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		4 / 7 VAL A 155
ILE A 327
GLY A 289
ARG A 161
 None
 0.90A 3bjwH-3dh9A:
undetectable		 3bjwH-3dh9A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		5 / 12 PHE A 181
PHE A 205
GLY A 204
ALA A 203
LEU A 282
 None
 1.00A 3hs6B-3dh9A:
undetectable		 3hs6B-3dh9A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		5 / 12 PHE A 471
LEU A 415
ILE A 476
LEU A 474
THR A 467
 None
 1.22A 3nrrA-3dh9A:
undetectable		 3nrrA-3dh9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		3 / 3 TYR A 329
ASP A 306
ASP A 326
 None
None
FAD  A 500 (-3.1A)
 1.00A 3ou7B-3dh9A:
undetectable		 3ou7B-3dh9A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		5 / 12 ALA A 284
LEU A 282
LEU A 191
ILE A 242
GLY A 204
 None
 0.95A 3q95A-3dh9A:
undetectable		 3q95A-3dh9A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		5 / 9 PHE A 244
VAL A 192
ILE A 242
GLY A 204
THR A 368
 None
 1.17A 3t3rB-3dh9A:
undetectable		 3t3rB-3dh9A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		5 / 9 PHE A 244
VAL A 192
ILE A 242
GLY A 204
THR A 368
 None
 1.17A 3t3rC-3dh9A:
undetectable		 3t3rC-3dh9A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		5 / 10 PHE A 244
VAL A 192
ILE A 242
GLY A 204
THR A 368
 None
 1.16A 3t3rD-3dh9A:
undetectable		 3t3rD-3dh9A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		4 / 6 PHE A 244
ALA A 234
LEU A 200
THR A 368
 None
 1.05A 4dtzB-3dh9A:
undetectable		 4dtzB-3dh9A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		5 / 12 PHE A 181
PHE A 205
GLY A 204
ALA A 203
LEU A 282
 None
 1.01A 4e1gB-3dh9A:
2.1		 4e1gB-3dh9A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		5 / 10 MET A  68
ALA A  71
GLU A 186
PHE A 205
LEU A 180
 None
 1.30A 4la0A-3dh9A:
undetectable		 4la0A-3dh9A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_B_198B601_1
(SERUM ALBUMIN)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		5 / 9 MET A  68
ALA A  71
GLU A 186
PHE A 205
LEU A 180
 None
 1.35A 4la0B-3dh9A:
2.6		 4la0B-3dh9A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		4 / 8 PHE A 244
SER A 236
GLU A 380
ASP A 226
 None
 1.21A 4qb9D-3dh9A:
undetectable		 4qb9D-3dh9A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		5 / 12 GLY A 208
GLY A 210
SER A  72
LEU A  73
ALA A  77
 None
 1.13A 4uckB-3dh9A:
undetectable		 4uckB-3dh9A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		3 / 3 MET A 237
GLN A 228
TYR A 414
 None
 1.11A 4udcA-3dh9A:
undetectable		 4udcA-3dh9A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		5 / 12 ALA A 284
LEU A 282
LEU A 191
ILE A 242
GLY A 204
 None
 0.96A 4xi3B-3dh9A:
undetectable		 4xi3B-3dh9A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		5 / 12 GLY A  21
GLY A  17
VAL A 155
VAL A 339
ALA A 338
 None
FAD  A 500 ( 4.7A)
None
None
FAD  A 500 ( 3.8A)
 0.96A 5kpcA-3dh9A:
undetectable		 5kpcA-3dh9A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		4 / 8 LEU A 452
VAL A 375
LEU A 430
ILE A 441
 None
 0.79A 6cb4A-3dh9A:
undetectable		 6cb4A-3dh9A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		3 / 3 LYS A 260
VAL A 277
ASP A 279
 None
 0.32A 6fgdA-3dh9A:
3.8		 6fgdA-3dh9A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 3dh9 THIOREDOXIN
REDUCTASE 1
(Drosophila
melanogaster) 		5 / 12 ILE A 328
ILE A 327
VAL A 310
THR A 316
ILE A 308
 None
 1.17A 6hlpA-3dh9A:
2.5		 6hlpA-3dh9A:
22.38