SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dho'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 3dho STREPTOGRAMIN A
ACETYLTRANSFERASE
(Enterococcus
faecium) 		4 / 6 PRO A   5
PHE A  19
LYS A  65
VAL A  32
 None
 1.48A 1l2iB-3dhoA:
undetectable		 1l2iB-3dhoA:
18.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 3dho STREPTOGRAMIN A
ACETYLTRANSFERASE
(Enterococcus
faecium) 		5 / 11 TYR A  54
HIS A  82
MET A 102
PRO A 103
LEU A 108
 None
 0.88A 1mrlA-3dhoA:
31.0
1mrlB-3dhoA:
30.9		 1mrlA-3dhoA:
100.00
1mrlB-3dhoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 3dho STREPTOGRAMIN A
ACETYLTRANSFERASE
(Enterococcus
faecium) 		5 / 11 TYR A  54
ILE A  56
HIS A  82
PRO A 103
LEU A 108
 None
 0.59A 1mrlA-3dhoA:
31.0
1mrlB-3dhoA:
30.9		 1mrlA-3dhoA:
100.00
1mrlB-3dhoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 3dho STREPTOGRAMIN A
ACETYLTRANSFERASE
(Enterococcus
faecium) 		6 / 12 TYR A  54
HIS A  82
ASN A  92
MET A 102
PRO A 103
LEU A 108
 None
 0.92A 1mrlB-3dhoA:
30.9
1mrlC-3dhoA:
23.5		 1mrlB-3dhoA:
100.00
1mrlC-3dhoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 3dho STREPTOGRAMIN A
ACETYLTRANSFERASE
(Enterococcus
faecium) 		6 / 12 TYR A  54
ILE A  56
HIS A  82
ASN A  92
PRO A 103
LEU A 108
 None
 0.70A 1mrlB-3dhoA:
30.9
1mrlC-3dhoA:
23.5		 1mrlB-3dhoA:
100.00
1mrlC-3dhoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 3dho STREPTOGRAMIN A
ACETYLTRANSFERASE
(Enterococcus
faecium) 		6 / 10 TYR A  54
HIS A  82
ASN A  92
LEU A  93
MET A 102
LEU A 108
 None
 0.88A 1mrlA-3dhoA:
31.0
1mrlC-3dhoA:
23.5		 1mrlA-3dhoA:
100.00
1mrlC-3dhoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 3dho STREPTOGRAMIN A
ACETYLTRANSFERASE
(Enterococcus
faecium) 		5 / 12 ALA A 156
GLY A 157
GLY A 158
ASP A 136
GLY A 117
 None
B2M  A 302 (-3.5A)
B2M  A 302 (-4.0A)
None
None
 0.99A 1sqfA-3dhoA:
undetectable		 1sqfA-3dhoA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 3dho STREPTOGRAMIN A
ACETYLTRANSFERASE
(Enterococcus
faecium) 		3 / 3 GLY A  72
GLU A  44
ASP A 125
 None
 0.70A 2b25B-3dhoA:
undetectable		 2b25B-3dhoA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 3dho STREPTOGRAMIN A
ACETYLTRANSFERASE
(Enterococcus
faecium) 		4 / 7 ILE A  69
TYR A  37
ILE A  20
GLN A  18
 None
 0.97A 3hgxA-3dhoA:
undetectable		 3hgxA-3dhoA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 3dho STREPTOGRAMIN A
ACETYLTRANSFERASE
(Enterococcus
faecium) 		5 / 11 GLY A 157
ALA A 156
ILE A 150
ILE A 116
ILE A 122
 B2M  A 302 (-3.5A)
None
None
None
None
 1.10A 4dt8A-3dhoA:
undetectable		 4dt8A-3dhoA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 3dho STREPTOGRAMIN A
ACETYLTRANSFERASE
(Enterococcus
faecium) 		5 / 10 ILE A 134
VAL A 146
GLY A 157
ILE A 164
VAL A 120
 None
None
B2M  A 302 (-3.5A)
B2M  A 302 ( 4.0A)
None
 1.08A 4j5jB-3dhoA:
undetectable		 4j5jB-3dhoA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3dho STREPTOGRAMIN A
ACETYLTRANSFERASE
(Enterococcus
faecium) 		4 / 7 VAL A 126
ILE A 116
ALA A 138
ILE A 115
 None
 0.78A 4uxqA-3dhoA:
undetectable		 4uxqA-3dhoA:
19.81