SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dhv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		5 / 12 ILE A 221
LEU A 198
PHE A 245
ILE A 216
THR A 488
 None
DAL  A 701 ( 4.1A)
None
None
None
 1.07A 1cd2A-3dhvA:
undetectable		 1cd2A-3dhvA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		4 / 7 VAL A 387
GLY A 385
THR A 381
ILE A 332
 None
 0.75A 1gtnC-3dhvA:
undetectable
1gtnD-3dhvA:
undetectable		 1gtnC-3dhvA:
9.22
1gtnD-3dhvA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		5 / 12 TYR A 440
ALA A 461
ILE A 462
MET A 480
PHE A 479
 None
 1.22A 1udtA-3dhvA:
undetectable		 1udtA-3dhvA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		4 / 6 LEU A 189
LEU A 281
LEU A 260
ILE A 290
 None
 1.02A 1z95A-3dhvA:
undetectable		 1z95A-3dhvA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		5 / 12 PHE A 268
LEU A 273
LEU A 319
LEU A 313
ARG A 279
 None
 1.23A 2bxfA-3dhvA:
undetectable		 2bxfA-3dhvA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		4 / 5 ALA A 192
ASN A 190
ILE A 203
ASP A 202
 None
 1.08A 2h4jA-3dhvA:
3.0		 2h4jA-3dhvA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		3 / 3 ARG A 329
GLY A 352
PRO A 353
 None
 0.77A 2hreD-3dhvA:
2.1		 2hreD-3dhvA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		3 / 3 LEU A 198
MET A 201
MET A  64
 DAL  A 701 ( 4.1A)
None
None
 0.99A 2vavF-3dhvA:
undetectable		 2vavF-3dhvA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		4 / 7 PHE A 180
LEU A 198
ALA A 302
ALA A 176
 None
DAL  A 701 ( 4.1A)
None
None
 0.84A 2vcvG-3dhvA:
1.8		 2vcvG-3dhvA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		4 / 7 LEU A 198
GLY A 270
GLY A 295
THR A 297
 DAL  A 701 ( 4.1A)
DAL  A 701 ( 3.1A)
AMP  A 711 ( 4.7A)
AMP  A 711 (-3.9A)
 0.62A 2wd9A-3dhvA:
37.8		 2wd9A-3dhvA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		4 / 8 LEU A 198
GLY A 270
GLY A 295
THR A 297
 DAL  A 701 ( 4.1A)
DAL  A 701 ( 3.1A)
AMP  A 711 ( 4.7A)
AMP  A 711 (-3.9A)
 0.61A 2wd9B-3dhvA:
37.2		 2wd9B-3dhvA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		5 / 10 THR A 152
LEU A 198
GLY A 270
GLY A 295
THR A 297
 None
DAL  A 701 ( 4.1A)
DAL  A 701 ( 3.1A)
AMP  A 711 ( 4.7A)
AMP  A 711 (-3.9A)
 0.63A 2wd9C-3dhvA:
37.2		 2wd9C-3dhvA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		4 / 7 GLN A  17
VAL A 187
GLY A 211
THR A 212
 None
 0.58A 2xrzB-3dhvA:
2.7		 2xrzB-3dhvA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		4 / 5 VAL A 493
GLN A 482
PHE A 245
ARG A 495
 None
 1.32A 3bjwE-3dhvA:
undetectable		 3bjwE-3dhvA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		4 / 6 VAL A 493
GLN A 482
PHE A 245
ARG A 495
 None
 1.25A 3bjwF-3dhvA:
undetectable		 3bjwF-3dhvA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		4 / 4 THR A 265
VAL A 308
GLY A 305
THR A 304
 None
 0.99A 3cflA-3dhvA:
undetectable		 3cflA-3dhvA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		5 / 11 ALA A  38
ASP A  35
ILE A  66
GLY A  70
ILE A 126
 None
 0.94A 3ekxB-3dhvA:
undetectable		 3ekxB-3dhvA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		4 / 5 PRO A  80
THR A 488
GLY A 491
LYS A 492
 None
None
None
DAL  A 701 ( 3.2A)
 0.94A 3elzB-3dhvA:
undetectable		 3elzB-3dhvA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		4 / 8 HIS A  59
ALA A 215
ILE A 216
ASN A 190
 None
 1.02A 3fxrA-3dhvA:
undetectable		 3fxrA-3dhvA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		5 / 11 LEU A  39
GLU A  46
LEU A 101
ARG A 116
GLY A  75
 None
 1.32A 3hm1B-3dhvA:
undetectable		 3hm1B-3dhvA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		5 / 12 LEU A   4
TYR A 204
LEU A 207
VAL A  72
GLY A  70
 None
 1.04A 3rr3C-3dhvA:
undetectable		 3rr3C-3dhvA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		5 / 12 LEU A   4
TYR A 204
LEU A 207
VAL A  72
GLY A  70
 None
 1.03A 3rr3D-3dhvA:
undetectable		 3rr3D-3dhvA:
23.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		5 / 7 PHE A 196
ASP A 197
GLY A 270
THR A 297
LYS A 492
 DAL  A 701 (-4.7A)
DAL  A 701 ( 2.7A)
DAL  A 701 ( 3.1A)
AMP  A 711 (-3.9A)
DAL  A 701 ( 3.2A)
 0.85A 3vnsA-3dhvA:
45.5		 3vnsA-3dhvA:
31.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		5 / 12 ASP A  37
THR A  14
PRO A  15
ILE A  66
ILE A   7
 None
 1.32A 4eb6B-3dhvA:
1.9
4eb6C-3dhvA:
undetectable		 4eb6B-3dhvA:
22.04
4eb6C-3dhvA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		4 / 8 ARG A  89
GLY A  98
ALA A  99
PRO A  80
 None
 0.83A 4eyrB-3dhvA:
undetectable		 4eyrB-3dhvA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		3 / 3 GLN A 186
THR A 184
THR A 209
 None
 0.69A 4fu9A-3dhvA:
undetectable		 4fu9A-3dhvA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		3 / 3 GLN A 186
THR A 184
THR A 209
 None
 0.67A 4fufA-3dhvA:
undetectable		 4fufA-3dhvA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		4 / 8 LEU A 227
SER A 484
GLY A 491
MET A 487
 None
 0.88A 4klrB-3dhvA:
2.2		 4klrB-3dhvA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		5 / 12 LEU A 103
LEU A   4
ALA A  40
SER A  36
LEU A  39
 None
 1.44A 4m11A-3dhvA:
undetectable		 4m11A-3dhvA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		4 / 7 LEU A 189
LEU A 281
LEU A 260
ILE A 290
 None
 1.01A 4okwA-3dhvA:
undetectable		 4okwA-3dhvA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		4 / 8 TYR A 151
ILE A 149
ILE A  79
ALA A  99
 None
 0.97A 4ou1A-3dhvA:
undetectable		 4ou1A-3dhvA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		5 / 7 PHE A 196
ASP A 197
GLY A 270
THR A 297
LYS A 492
 DAL  A 701 (-4.7A)
DAL  A 701 ( 2.7A)
DAL  A 701 ( 3.1A)
AMP  A 711 (-3.9A)
DAL  A 701 ( 3.2A)
 0.65A 4zxiA-3dhvA:
43.9		 4zxiA-3dhvA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		3 / 3 PHE A 245
ILE A 221
ASP A 494
 None
 0.67A 5cswA-3dhvA:
undetectable		 5cswA-3dhvA:
21.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		5 / 7 PHE A 196
ASP A 197
GLY A 270
GLY A 295
LYS A 492
 DAL  A 701 (-4.7A)
DAL  A 701 ( 2.7A)
DAL  A 701 ( 3.1A)
AMP  A 711 ( 4.7A)
DAL  A 701 ( 3.2A)
 0.77A 5n9xA-3dhvA:
46.4		 5n9xA-3dhvA:
31.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		5 / 12 GLU A  34
ASP A  35
ASP A  16
ALA A  19
PRO A  62
 None
 1.27A 5syeB-3dhvA:
undetectable		 5syeB-3dhvA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE
(Bacillus
cereus) 		5 / 12 GLY A 270
THR A 242
PRO A 243
THR A 304
LEU A 392
 DAL  A 701 ( 3.1A)
None
None
None
None
 1.17A 5ybbA-3dhvA:
undetectable		 5ybbA-3dhvA:
23.77