SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dhw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 3dhw D-METHIONINE
TRANSPORT SYSTEM
PERMEASE PROTEIN
METI
(Escherichia
coli) 		5 / 10 GLY A  24
PHE A  21
SER A  23
LEU A 154
LEU A 157
 None
 1.38A 1a8uA-3dhwA:
undetectable		 1a8uA-3dhwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 3dhw D-METHIONINE
TRANSPORT SYSTEM
PERMEASE PROTEIN
METI
(Escherichia
coli) 		5 / 10 GLY A  24
PHE A  21
SER A  23
LEU A 154
LEU A 157
 None
 1.37A 1a8uB-3dhwA:
undetectable		 1a8uB-3dhwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3dhw D-METHIONINE
TRANSPORT SYSTEM
PERMEASE PROTEIN
METI
METHIONINE IMPORT
ATP-BINDING PROTEIN
METN
(Escherichia
coli) 		5 / 12 ALA C 150
PHE C  88
ARG A 124
LEU C  54
ARG C  49
 None
 1.28A 1dreA-3dhwC:
undetectable		 1dreA-3dhwC:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3dhw METHIONINE IMPORT
ATP-BINDING PROTEIN
METN
(Escherichia
coli) 		5 / 10 ALA C 150
SER C 178
LEU C 183
PHE C  88
ILE C  87
 None
 1.21A 1g5yC-3dhwC:
undetectable		 1g5yC-3dhwC:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 3dhw METHIONINE IMPORT
ATP-BINDING PROTEIN
METN
(Escherichia
coli) 		5 / 11 TYR C  34
GLU C 221
VAL C 213
ILE C 214
ILE C   7
 None
 1.32A 2dg3A-3dhwC:
undetectable		 2dg3A-3dhwC:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 3dhw METHIONINE IMPORT
ATP-BINDING PROTEIN
METN
(Escherichia
coli) 		5 / 9 LEU C   4
GLU C  68
ILE C   7
GLY C  60
LEU C  69
 None
 1.02A 2qmmA-3dhwC:
undetectable		 2qmmA-3dhwC:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 3dhw METHIONINE IMPORT
ATP-BINDING PROTEIN
METN
(Escherichia
coli) 		5 / 11 LEU C   4
GLU C  68
ILE C   7
GLY C  60
LEU C  69
 None
 1.01A 2qmmA-3dhwC:
undetectable
2qmmB-3dhwC:
undetectable		 2qmmA-3dhwC:
21.47
2qmmB-3dhwC:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3dhw METHIONINE IMPORT
ATP-BINDING PROTEIN
METN
(Escherichia
coli) 		4 / 6 LEU C 127
ARG C 189
ILE C 186
ILE C   2
 None
 0.85A 2xkwB-3dhwC:
undetectable		 2xkwB-3dhwC:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 3dhw D-METHIONINE
TRANSPORT SYSTEM
PERMEASE PROTEIN
METI
(Escherichia
coli) 		4 / 7 LEU A 199
ALA A 162
GLY A 176
ILE A 175
 None
 0.88A 3spkB-3dhwA:
undetectable		 3spkB-3dhwA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3dhw METHIONINE IMPORT
ATP-BINDING PROTEIN
METN
(Escherichia
coli) 		3 / 3 THR C   8
VAL C  10
GLU C  59
 None
 0.70A 3v4tA-3dhwC:
undetectable
3v4tD-3dhwC:
undetectable		 3v4tA-3dhwC:
22.22
3v4tD-3dhwC:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 3dhw METHIONINE IMPORT
ATP-BINDING PROTEIN
METN
(Escherichia
coli) 		5 / 12 ILE C 197
LEU C 195
GLY C 217
LEU C  26
GLY C  41
 None
 1.02A 3vaqA-3dhwC:
undetectable		 3vaqA-3dhwC:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 3dhw METHIONINE IMPORT
ATP-BINDING PROTEIN
METN
(Escherichia
coli) 		5 / 12 ILE C 197
LEU C 195
GLY C 217
LEU C  26
GLY C  41
 None
 0.95A 3vasB-3dhwC:
undetectable		 3vasB-3dhwC:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3dhw METHIONINE IMPORT
ATP-BINDING PROTEIN
METN
(Escherichia
coli) 		4 / 8 TYR C  34
LEU C  47
VAL C  24
GLN C 222
 None
 0.98A 4em2A-3dhwC:
undetectable		 4em2A-3dhwC:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3dhw D-METHIONINE
TRANSPORT SYSTEM
PERMEASE PROTEIN
METI
(Escherichia
coli) 		5 / 11 GLY A  88
GLY A 170
GLY A 171
ALA A  92
LEU A  89
 None
 1.09A 4l8fB-3dhwA:
undetectable		 4l8fB-3dhwA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3dhw D-METHIONINE
TRANSPORT SYSTEM
PERMEASE PROTEIN
METI
(Escherichia
coli) 		5 / 11 GLY A  88
GLY A 170
GLY A 171
ALA A  92
LEU A  89
 None
 1.09A 4l8fD-3dhwA:
undetectable		 4l8fD-3dhwA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3dhw METHIONINE IMPORT
ATP-BINDING PROTEIN
METN
(Escherichia
coli) 		5 / 12 LEU C 162
ALA C 167
ALA C 150
ILE C 179
VAL C 128
 None
 1.02A 4nkxA-3dhwC:
undetectable		 4nkxA-3dhwC:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3dhw METHIONINE IMPORT
ATP-BINDING PROTEIN
METN
(Escherichia
coli) 		5 / 12 LEU C 162
ALA C 167
ALA C 150
ILE C 179
VAL C 128
 None
 1.08A 4nkxC-3dhwC:
undetectable		 4nkxC-3dhwC:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 3dhw METHIONINE IMPORT
ATP-BINDING PROTEIN
METN
(Escherichia
coli) 		4 / 6 LEU C 247
ASP C 248
LEU C 340
ILE C 311
 None
 1.02A 4y4dA-3dhwC:
undetectable		 4y4dA-3dhwC:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 3dhw D-METHIONINE
TRANSPORT SYSTEM
PERMEASE PROTEIN
METI
(Escherichia
coli) 		5 / 8 ALA A  91
PRO A  95
GLY A  88
ALA A 169
GLY A 168
 None
 1.41A 4zjzB-3dhwA:
undetectable		 4zjzB-3dhwA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 3dhw METHIONINE IMPORT
ATP-BINDING PROTEIN
METN
(Escherichia
coli) 		4 / 7 ILE C 207
ILE C 179
ILE C  87
LEU C 171
 None
 0.80A 5fukA-3dhwC:
undetectable
5fukB-3dhwC:
undetectable		 5fukA-3dhwC:
21.90
5fukB-3dhwC:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 3dhw METHIONINE IMPORT
ATP-BINDING PROTEIN
METN
(Escherichia
coli) 		5 / 11 LEU C  47
ILE C  87
GLY C  85
ILE C  84
ILE C  48
 None
 1.29A 5kr2B-3dhwC:
undetectable		 5kr2B-3dhwC:
16.45