SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3din'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)
3din PREPROTEIN
TRANSLOCASE SUBUNIT
SECE
PREPROTEIN
TRANSLOCASE SUBUNIT
SECY

(Thermotoga
maritima)
4 / 7 LEU D  37
ALA C 398
GLY C 400
PHE D  30
None
0.88A 2wq5A-3dinD:
undetectable
2wq5A-3dinD:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
3din PREPROTEIN
TRANSLOCASE SUBUNIT
SECE
PREPROTEIN
TRANSLOCASE SUBUNIT
SECY

(Thermotoga
maritima)
5 / 8 LEU C 224
GLY C 400
ALA C 402
THR D  40
ILE D  36
None
1.09A 3jusB-3dinC:
undetectable
3jusB-3dinC:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
3din PREPROTEIN
TRANSLOCASE SUBUNIT
SECE
PREPROTEIN
TRANSLOCASE SUBUNIT
SECY

(Thermotoga
maritima)
5 / 9 LEU C 224
GLY C 400
ALA C 402
THR D  40
ILE D  36
None
1.09A 3jusB-3dinC:
undetectable
3jusB-3dinC:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)
3din PREPROTEIN
TRANSLOCASE SUBUNIT
SECE
PREPROTEIN
TRANSLOCASE SUBUNIT
SECY

(Thermotoga
maritima)
5 / 11 ILE C  26
ILE D  58
SER D  56
ILE D  50
GLY D  53
None
0.92A 3kw4A-3dinC:
0.6
3kw4A-3dinC:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)
3din PREPROTEIN
TRANSLOCASE SUBUNIT
SECG
PREPROTEIN
TRANSLOCASE SUBUNIT
SECY

(Thermotoga
maritima;
Thermotoga
sp.
RQ2)
3 / 3 HIS E  40
ARG C 113
GLU C 110
None
0.92A 3qf1A-3dinE:
undetectable
3qf1A-3dinE:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)
3din PREPROTEIN
TRANSLOCASE SUBUNIT
SECY
PREPROTEIN
TRANSLOCASE SUBUNIT
SECG

(Thermotoga
maritima;
Thermotoga
sp.
RQ2)
4 / 7 ILE C 187
LYS E  26
PHE C 170
GLY C 167
None
1.22A 3sj0X-3dinC:
undetectable
3sj0X-3dinC:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)
3din PREPROTEIN
TRANSLOCASE SUBUNIT
SECY

(Thermotoga
maritima)
5 / 12 GLU C 330
ARG C 107
ALA C 236
GLU C 237
ARG C 336
None
1.48A 4mwrA-3dinC:
undetectable
4mwrA-3dinC:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)
3din PREPROTEIN
TRANSLOCASE SUBUNIT
SECY

(Thermotoga
maritima)
5 / 12 LEU C 174
ILE C 187
PHE C  28
ILE C 189
ALA C 398
None
1.31A 5j7wC-3dinC:
undetectable
5j7wC-3dinC:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_1
(NEURAMINIDASE)
3din PREPROTEIN
TRANSLOCASE SUBUNIT
SECY

(Thermotoga
maritima)
5 / 12 GLU C 330
ARG C 107
ALA C 236
GLU C 237
ARG C 336
None
1.43A 5l17A-3dinC:
undetectable
5l17A-3dinC:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
3din PREPROTEIN
TRANSLOCASE SUBUNIT
SECY

(Thermotoga
maritima)
4 / 6 ILE C 220
ILE C 397
LEU C 396
PHE C  75
None
1.02A 5vkqC-3dinC:
3.1
5vkqD-3dinC:
3.1
5vkqC-3dinC:
13.59
5vkqD-3dinC:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)
3din PREPROTEIN
TRANSLOCASE SUBUNIT
SECY

(Thermotoga
maritima)
5 / 12 LEU C 174
ILE C 187
PHE C  28
ILE C 189
ALA C 398
None
1.34A 6qyaB-3dinC:
undetectable
6qyaB-3dinC:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)
3din PREPROTEIN
TRANSLOCASE SUBUNIT
SECY

(Thermotoga
maritima)
5 / 12 LEU C 174
ILE C 187
PHE C  28
ILE C 189
ALA C 398
None
1.34A 6qyaD-3dinC:
undetectable
6qyaD-3dinC:
20.18