SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dip'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 3dip ENOLASE
(unidentified) 		5 / 12 LEU A  93
LEU A  96
HIS A  47
LEU A   7
ILE A   4
 None
 1.25A 1fmlA-3dipA:
undetectable		 1fmlA-3dipA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 3dip ENOLASE
(unidentified) 		5 / 12 LEU A  93
LEU A  96
HIS A  47
LEU A   7
ILE A   4
 None
 1.25A 1fmlB-3dipA:
undetectable		 1fmlB-3dipA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 3dip ENOLASE
(unidentified) 		5 / 12 GLY A 209
GLN A 210
VAL A 239
ALA A 158
LEU A 161
 None
 1.14A 1gs4A-3dipA:
undetectable		 1gs4A-3dipA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 3dip ENOLASE
(unidentified) 		4 / 6 SER A  64
THR A  63
ASP A  90
TRP A  94
 None
 0.99A 1mxdA-3dipA:
7.6		 1mxdA-3dipA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 3dip ENOLASE
(unidentified) 		4 / 8 SER A  64
THR A  63
ASP A  90
TRP A  94
 None
 1.01A 1mxgA-3dipA:
6.3		 1mxgA-3dipA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3dip ENOLASE
(unidentified) 		3 / 3 LEU A 332
LEU A 292
MET A 291
 None
 0.84A 2itzA-3dipA:
undetectable		 2itzA-3dipA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 3dip ENOLASE
(unidentified) 		5 / 12 MET A 249
ALA A 233
LEU A 234
ALA A 235
ILE A 266
 None
 1.21A 2jjpA-3dipA:
undetectable		 2jjpA-3dipA:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 3dip ENOLASE
(unidentified) 		5 / 12 GLY A 209
GLN A 210
VAL A 239
ALA A 158
LEU A 161
 None
 1.16A 2oz7A-3dipA:
undetectable		 2oz7A-3dipA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3dip ENOLASE
(unidentified) 		5 / 12 GLY A 331
ALA A 338
HIS A 320
LEU A 292
VAL A 290
 None
None
SIC  A 321 ( 3.1A)
None
None
 0.90A 2yqzB-3dipA:
undetectable		 2yqzB-3dipA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3dip ENOLASE
(unidentified) 		5 / 10 GLU A 280
ARG A 277
GLY A 274
CYH A 297
LEU A 334
 None
 1.41A 3adsA-3dipA:
undetectable		 3adsA-3dipA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3dip ENOLASE
(unidentified) 		4 / 6 GLY A 223
ALA A 247
LEU A 258
PRO A 245
 None
 0.97A 3bgdA-3dipA:
undetectable		 3bgdA-3dipA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 3dip ENOLASE
(unidentified) 		5 / 12 LEU A  69
ASP A  90
VAL A  89
ILE A  91
GLY A 299
 None
 1.07A 3hgiA-3dipA:
undetectable		 3hgiA-3dipA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3dip ENOLASE
(unidentified) 		4 / 5 LEU A  69
GLN A  49
THR A  50
GLU A  68
 None
 1.13A 3n58C-3dipA:
2.4		 3n58C-3dipA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 3dip ENOLASE
(unidentified) 		4 / 8 ALA A  86
VAL A  89
ASP A  90
LEU A  93
 None
 0.32A 3roxA-3dipA:
undetectable		 3roxA-3dipA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 3dip ENOLASE
(unidentified) 		3 / 3 LEU A 332
HIS A 333
MET A 329
 None
 0.73A 3thrD-3dipA:
undetectable		 3thrD-3dipA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 3dip ENOLASE
(unidentified) 		4 / 7 PRO A  16
ARG A  15
GLY A 324
PRO A 325
 None
 1.36A 3ucbB-3dipA:
undetectable		 3ucbB-3dipA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 3dip ENOLASE
(unidentified) 		3 / 3 LEU A 165
MET A 173
ASP A 127
 None
 0.77A 4j7xB-3dipA:
2.1		 4j7xB-3dipA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 3dip ENOLASE
(unidentified) 		5 / 12 ILE A  91
GLN A 344
LEU A 300
LEU A 317
LEU A 292
 None
 1.43A 4qynB-3dipA:
undetectable		 4qynB-3dipA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 3dip ENOLASE
(unidentified) 		3 / 3 GLU A  22
ARG A   8
GLN A  99
 None
 0.96A 4rtbA-3dipA:
4.5		 4rtbA-3dipA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3dip ENOLASE
(unidentified) 		3 / 3 THR A 275
HIS A 333
LEU A 294
 None
 0.84A 5axdC-3dipA:
2.6		 5axdC-3dipA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3dip ENOLASE
(unidentified) 		3 / 3 THR A 323
HIS A 337
LEU A 300
 SIC  A 321 ( 3.8A)
None
None
 0.85A 5axdC-3dipA:
2.6		 5axdC-3dipA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3dip ENOLASE
(unidentified) 		4 / 7 ALA A  97
GLY A 299
THR A 275
GLU A 302
 None
 0.89A 5btdA-3dipA:
undetectable
5btdB-3dipA:
undetectable
5btdC-3dipA:
undetectable		 5btdA-3dipA:
24.46
5btdB-3dipA:
25.74
5btdC-3dipA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3dip ENOLASE
(unidentified) 		4 / 7 ALA A  97
GLY A 299
THR A 275
GLU A 302
 None
 0.90A 5btdA-3dipA:
undetectable
5btdC-3dipA:
undetectable
5btdD-3dipA:
undetectable		 5btdA-3dipA:
24.46
5btdC-3dipA:
24.46
5btdD-3dipA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3dip ENOLASE
(unidentified) 		4 / 6 ALA A  97
GLY A 299
THR A 275
GLU A 302
 None
 0.96A 5btgA-3dipA:
undetectable
5btgB-3dipA:
undetectable
5btgC-3dipA:
undetectable		 5btgA-3dipA:
24.46
5btgB-3dipA:
25.74
5btgC-3dipA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3dip ENOLASE
(unidentified) 		5 / 10 ALA A 310
LEU A 282
MET A 281
GLY A 269
LEU A 292
 None
 1.31A 5dx3A-3dipA:
undetectable		 5dx3A-3dipA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 3dip ENOLASE
(unidentified) 		5 / 10 ALA A 310
LEU A 282
MET A 281
GLY A 269
LEU A 292
 None
 1.37A 5dxbA-3dipA:
undetectable		 5dxbA-3dipA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 3dip ENOLASE
(unidentified) 		4 / 7 LEU A 334
THR A 295
THR A  35
LEU A 109
 None
 1.11A 5jq7B-3dipA:
undetectable		 5jq7B-3dipA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3dip ENOLASE
(unidentified) 		5 / 12 LEU A 292
ASP A 244
GLY A 268
LEU A 282
ALA A 310
 None
 0.99A 5kbwA-3dipA:
undetectable		 5kbwA-3dipA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3dip ENOLASE
(unidentified) 		5 / 12 LEU A 292
ASP A 244
GLY A 268
LEU A 282
ALA A 310
 None
 1.07A 5kc4E-3dipA:
undetectable		 5kc4E-3dipA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3dip ENOLASE
(unidentified) 		5 / 12 ILE A 389
VAL A 359
LEU A 382
VAL A 386
ILE A  10
 None
 1.02A 5mugA-3dipA:
3.1		 5mugA-3dipA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3dip ENOLASE
(unidentified) 		5 / 9 ALA A 310
LEU A 282
MET A 281
GLY A 269
LEU A 292
 None
 1.43A 5wgqA-3dipA:
undetectable		 5wgqA-3dipA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3dip ENOLASE
(unidentified) 		5 / 11 VAL A 239
ALA A 235
LEU A 218
THR A 262
ALA A 264
 None
 1.49A 6dk1C-3dipA:
undetectable		 6dk1C-3dipA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 3dip ENOLASE
(unidentified) 		4 / 6 ARG A  84
SER A  80
THR A  50
ALA A  88
 None
 1.18A 6ma6A-3dipA:
undetectable		 6ma6A-3dipA:
9.27