SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dit'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3dit PROTEIN MOTHERS
AGAINST DPP
(Drosophila
melanogaster) 		5 / 12 ILE A 426
GLY A 323
VAL A 286
SER A 341
TYR A 266
 None
 1.26A 1nbhA-3ditA:
undetectable		 1nbhA-3ditA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3dit PROTEIN MOTHERS
AGAINST DPP
(Drosophila
melanogaster) 		5 / 12 ILE A 426
GLY A 323
VAL A 286
SER A 341
TYR A 266
 None
 1.26A 1nbhC-3ditA:
undetectable		 1nbhC-3ditA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3dit PROTEIN MOTHERS
AGAINST DPP
(Drosophila
melanogaster) 		5 / 12 ILE A 426
GLY A 323
VAL A 286
SER A 341
TYR A 266
 None
 1.26A 1nbhD-3ditA:
undetectable		 1nbhD-3ditA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3dit PROTEIN MOTHERS
AGAINST DPP
(Drosophila
melanogaster) 		5 / 12 THR A 316
GLY A 323
GLY A 321
ASP A 340
MET A 404
 None
 1.23A 2zw9B-3ditA:
undetectable		 2zw9B-3ditA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 3dit PROTEIN MOTHERS
AGAINST DPP
(Drosophila
melanogaster) 		4 / 8 CYH A 424
THR A 312
ILE A 313
THR A 316
 None
 0.88A 3bpxA-3ditA:
undetectable
3bpxB-3ditA:
undetectable		 3bpxA-3ditA:
18.27
3bpxB-3ditA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3dit PROTEIN MOTHERS
AGAINST DPP
(Drosophila
melanogaster) 		3 / 3 PHE A 356
CYH A 350
HIS A 354
 None
 1.15A 3u9fF-3ditA:
undetectable		 3u9fF-3ditA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3dit PROTEIN MOTHERS
AGAINST DPP
(Drosophila
melanogaster) 		3 / 3 PHE A 356
CYH A 350
HIS A 354
 None
 1.16A 3u9fG-3ditA:
undetectable		 3u9fG-3ditA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3dit PROTEIN MOTHERS
AGAINST DPP
(Drosophila
melanogaster) 		3 / 3 PHE A 356
CYH A 350
HIS A 354
 None
 1.19A 3u9fL-3ditA:
undetectable		 3u9fL-3ditA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3dit PROTEIN MOTHERS
AGAINST DPP
(Drosophila
melanogaster) 		3 / 3 PHE A 356
CYH A 350
HIS A 354
 None
 1.07A 3u9fS-3ditA:
undetectable		 3u9fS-3ditA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 3dit PROTEIN MOTHERS
AGAINST DPP
(Drosophila
melanogaster) 		3 / 3 ARG A 309
TYR A 266
GLU A 268
 None
 0.61A 4zzbE-3ditA:
undetectable		 4zzbE-3ditA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 3dit PROTEIN MOTHERS
AGAINST DPP
(Drosophila
melanogaster) 		4 / 6 HIS A 353
ASN A 375
VAL A 333
LEU A 370
 None
 1.28A 5xdhA-3ditA:
undetectable
5xdhC-3ditA:
undetectable		 5xdhA-3ditA:
17.65
5xdhC-3ditA:
17.65