SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dj4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  56
ILE A  63
LEU A  41
VAL A  67
GLY A  68
 None
 1.10A 1e7aA-3dj4A:
undetectable		 1e7aA-3dj4A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 334
ALA A 335
ILE A 366
GLY A 367
ILE A 331
 None
 0.81A 1hxbA-3dj4A:
undetectable		 1hxbA-3dj4A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 343
GLY A 356
VAL A 378
THR A 347
VAL A 361
 None
 0.89A 1t7jA-3dj4A:
undetectable		 1t7jA-3dj4A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		4 / 8 LEU A  97
LEU A 199
VAL A 213
VAL A 110
 None
 1.00A 2bdmA-3dj4A:
undetectable		 2bdmA-3dj4A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		6 / 12 LEU A 349
ALA A 319
ASP A 317
ILE A 298
VAL A 322
ILE A 331
 None
 1.44A 2f8gB-3dj4A:
undetectable		 2f8gB-3dj4A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  52
LEU A 100
ALA A  99
ARG A 193
LEU A  12
 None
None
None
None
UD1  A4000 (-4.1A)
 1.40A 2oaxE-3dj4A:
undetectable		 2oaxE-3dj4A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 199
LEU A 196
GLN A 205
LEU A  10
VAL A 108
 None
 1.07A 2qd4B-3dj4A:
2.6		 2qd4B-3dj4A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 THR A 111
LEU A 118
VAL A 229
LEU A 123
ILE A 127
 None
 1.08A 3ijdA-3dj4A:
undetectable		 3ijdA-3dj4A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 118
VAL A 224
ALA A 182
GLY A 183
ILE A 153
 None
None
None
UD1  A4000 ( 4.5A)
None
 0.89A 3ku1A-3dj4A:
2.5		 3ku1A-3dj4A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 118
VAL A 224
ALA A 182
GLY A 183
ILE A 153
 None
None
None
UD1  A4000 ( 4.5A)
None
 0.92A 3ku1C-3dj4A:
2.2		 3ku1C-3dj4A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  44
LEU A 123
ALA A 124
VAL A  54
ILE A  53
 None
 0.81A 3oapA-3dj4A:
undetectable		 3oapA-3dj4A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 118
VAL A  40
VAL A 184
ASP A 114
 None
None
None
MG  A 496 ( 2.6A)
 0.95A 3rgfA-3dj4A:
undetectable		 3rgfA-3dj4A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 349
GLY A 334
ALA A 319
VAL A 304
ILE A 331
 None
 0.81A 3s54A-3dj4A:
undetectable		 3s54A-3dj4A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 349
GLY A 350
GLY A 353
THR A 370
 None
 0.79A 3si7A-3dj4A:
undetectable		 3si7A-3dj4A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 11 VAL A  27
ALA A  13
LEU A  37
VAL A  80
LEU A  56
 None
UD1  A4000 (-4.8A)
None
None
None
 1.01A 3zosA-3dj4A:
undetectable
3zosB-3dj4A:
undetectable		 3zosA-3dj4A:
21.78
3zosB-3dj4A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		6 / 12 ILE A  78
LEU A  37
GLY A 113
THR A 111
VAL A   9
ILE A  53
 None
None
UD1  A4000 (-4.1A)
None
None
None
 1.07A 4c9lA-3dj4A:
undetectable		 4c9lA-3dj4A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		6 / 12 ILE A  78
LEU A  37
GLY A 113
THR A 111
VAL A   9
ILE A  53
 None
None
UD1  A4000 (-4.1A)
None
None
None
 1.04A 4c9lB-3dj4A:
undetectable		 4c9lB-3dj4A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		6 / 12 ILE A  78
LEU A  37
GLY A 113
THR A 111
VAL A   9
ILE A  53
 None
None
UD1  A4000 (-4.1A)
None
None
None
 1.14A 4c9oA-3dj4A:
undetectable		 4c9oA-3dj4A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		6 / 12 ILE A  78
LEU A  37
GLY A 113
THR A 111
VAL A   9
ILE A  53
 None
None
UD1  A4000 (-4.1A)
None
None
None
 1.14A 4c9oB-3dj4A:
undetectable		 4c9oB-3dj4A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 253
THR A 271
TRP A 273
 None
 1.26A 4d7hA-3dj4A:
undetectable		 4d7hA-3dj4A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 319
ILE A 298
GLY A 305
VAL A 313
VAL A 315
 None
 0.91A 4j5jB-3dj4A:
undetectable		 4j5jB-3dj4A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 100
ILE A  53
LEU A  52
ARG A  51
 None
 0.85A 4mghA-3dj4A:
undetectable		 4mghA-3dj4A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 11 ILE A  44
LEU A 123
ALA A 124
VAL A  54
LEU A  74
 None
 1.12A 4nqaA-3dj4A:
undetectable		 4nqaA-3dj4A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 100
LEU A  97
GLY A  96
LEU A  12
VAL A 109
 None
None
None
UD1  A4000 (-4.1A)
None
 1.05A 4ok1A-3dj4A:
undetectable		 4ok1A-3dj4A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 100
LEU A  97
GLY A  96
LEU A  12
VAL A 109
 None
None
None
UD1  A4000 (-4.1A)
None
 1.16A 4olmA-3dj4A:
undetectable		 4olmA-3dj4A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 253
THR A 271
TRP A 273
 None
 1.25A 4ug5A-3dj4A:
undetectable		 4ug5A-3dj4A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 253
THR A 271
TRP A 273
 None
 1.21A 4uglA-3dj4A:
undetectable		 4uglA-3dj4A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 253
THR A 271
TRP A 273
 None
 1.27A 5g6cA-3dj4A:
undetectable		 5g6cA-3dj4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 ARG A 405
GLY A 346
GLY A 326
SER A 327
GLY A 379
 None
 1.16A 5hikA-3dj4A:
2.9		 5hikA-3dj4A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 11 ILE A  44
LEU A 123
ALA A 124
VAL A  54
LEU A  74
 None
 1.13A 5ji0A-3dj4A:
undetectable		 5ji0A-3dj4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 412
ILE A 389
ALA A 381
THR A 406
 None
 0.65A 5og9A-3dj4A:
undetectable		 5og9A-3dj4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 349
GLY A 334
ALA A 319
VAL A 304
ILE A 331
 None
 0.91A 5t8hB-3dj4A:
undetectable		 5t8hB-3dj4A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		6 / 11 ASP A 114
GLY A  15
GLY A  17
LEU A  37
SER A  35
LEU A  28
 MG  A 496 ( 2.6A)
UD1  A4000 (-3.6A)
None
None
None
None
 1.34A 5twjD-3dj4A:
undetectable		 5twjD-3dj4A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		3 / 3 THR A  30
MET A  36
HIS A  39
 None
 1.03A 5uunA-3dj4A:
undetectable		 5uunA-3dj4A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 192
VAL A 108
VAL A  93
ILE A  53
LEU A 100
 None
 1.17A 6h1lA-3dj4A:
undetectable		 6h1lA-3dj4A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 446
ALA A 434
GLY A 415
THR A 414
THR A 418
 None
 1.01A 6hwdH-3dj4A:
undetectable
6hwdI-3dj4A:
undetectable		 6hwdH-3dj4A:
16.35
6hwdI-3dj4A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 3dj4 BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 446
ALA A 434
GLY A 415
THR A 414
THR A 418
 None
 1.01A 6hwdV-3dj4A:
undetectable		 6hwdV-3dj4A:
16.35