SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3djb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3djb HYDROLASE, HD FAMILY
(Bacillus
thuringiensis) 		4 / 6 GLU A 192
LEU A 124
ASP A 120
LEU A 117
 None
 0.84A 1mt1B-3djbA:
undetectable
1mt1C-3djbA:
undetectable		 1mt1B-3djbA:
19.63
1mt1C-3djbA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3djb HYDROLASE, HD FAMILY
(Bacillus
thuringiensis) 		4 / 6 GLU A 192
LEU A 124
ASP A 120
LEU A 117
 None
 0.89A 1mt1D-3djbA:
undetectable
1mt1E-3djbA:
undetectable		 1mt1D-3djbA:
19.63
1mt1E-3djbA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 3djb HYDROLASE, HD FAMILY
(Bacillus
thuringiensis) 		4 / 8 ASP A 122
ASP A  59
HIS A  29
HIS A  34
 MG  A 224 (-2.6A)
MG  A 224 (-3.4A)
MG  A 224 (-3.9A)
None
 1.09A 2q0iA-3djbA:
undetectable		 2q0iA-3djbA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3djb HYDROLASE, HD FAMILY
(Bacillus
thuringiensis) 		4 / 5 ILE A  97
VAL A  14
LEU A  18
ASP A  59
 None
None
None
MG  A 224 (-3.4A)
 1.21A 3wzdA-3djbA:
undetectable		 3wzdA-3djbA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 3djb HYDROLASE, HD FAMILY
(Bacillus
thuringiensis) 		4 / 5 PHE A 136
PHE A 173
ILE A 132
GLY A 131
 None
 1.00A 4ejjC-3djbA:
undetectable		 4ejjC-3djbA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 3djb HYDROLASE, HD FAMILY
(Bacillus
thuringiensis) 		5 / 12 PHE A  49
PHE A  13
ILE A  17
ALA A  61
ALA A  54
 None
 1.26A 5vcgA-3djbA:
undetectable		 5vcgA-3djbA:
19.10