SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3djc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		5 / 12 ALA A 115
ALA A 116
LEU A 220
VAL A 105
CYH A 137
 None
 0.92A 1fm9A-3djcA:
undetectable		 1fm9A-3djcA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		5 / 12 ILE A 173
GLY A 131
GLY A 224
LEU A 154
ASP A 108
 None
 1.11A 1i9gA-3djcA:
undetectable		 1i9gA-3djcA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		5 / 12 ILE A 173
ILE A 174
TYR A 193
ILE A 128
ALA A 221
 None
 1.15A 1jtxA-3djcA:
undetectable		 1jtxA-3djcA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		5 / 12 ALA A 115
ALA A 116
LEU A 220
VAL A 105
CYH A 137
 None
 0.95A 1k74A-3djcA:
undetectable		 1k74A-3djcA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		5 / 12 CYH A 200
ASP A 129
GLY A 131
TYR A 193
GLN A 232
 None
 1.37A 1oltA-3djcA:
undetectable		 1oltA-3djcA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		5 / 12 ALA A 115
ALA A 116
LEU A 220
VAL A 105
CYH A 137
 None
 0.87A 1xiuB-3djcA:
undetectable		 1xiuB-3djcA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		5 / 12 ALA A 115
ALA A 116
LEU A 220
VAL A 105
CYH A 137
 None
 0.93A 1xlsA-3djcA:
undetectable		 1xlsA-3djcA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		5 / 12 ALA A 115
ALA A 116
LEU A 220
VAL A 105
CYH A 137
 None
 0.92A 1xlsB-3djcA:
undetectable		 1xlsB-3djcA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		5 / 12 ALA A 115
ALA A 116
LEU A 220
VAL A 105
CYH A 137
 None
 0.93A 1xlsC-3djcA:
undetectable		 1xlsC-3djcA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		5 / 12 ALA A 115
ALA A 116
LEU A 220
VAL A 105
CYH A 137
 None
 0.94A 1xlsD-3djcA:
undetectable		 1xlsD-3djcA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		7 / 11 ASN A   9
VAL A  64
TYR A  99
GLY A 106
ASP A 108
THR A 135
ILE A 150
 None
 0.86A 2f9wA-3djcA:
24.7
2f9wB-3djcA:
25.1		 2f9wA-3djcA:
26.87
2f9wB-3djcA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		5 / 8 TYR A  99
GLY A 106
ASP A 108
THR A 135
ILE A 150
 None
 0.87A 2f9wA-3djcA:
24.7
2f9wB-3djcA:
25.1		 2f9wA-3djcA:
26.87
2f9wB-3djcA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		4 / 5 ILE A 114
LEU A 249
ALA A 111
PHE A  17
 None
 0.87A 2opxA-3djcA:
undetectable		 2opxA-3djcA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		5 / 12 ILE A 173
GLY A 131
GLY A 224
LEU A 154
ASP A 108
 None
 1.17A 2yvlD-3djcA:
undetectable		 2yvlD-3djcA:
23.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BEX_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		5 / 10 ASN A   9
VAL A  64
GLY A 106
ASP A 108
THR A 135
 None
 0.65A 3bexA-3djcA:
30.4
3bexB-3djcA:
30.4		 3bexA-3djcA:
36.69
3bexB-3djcA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BEX_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		5 / 9 ASN A   9
VAL A  64
GLY A 106
ASP A 108
THR A 135
 None
 0.66A 3bexA-3djcA:
30.4
3bexB-3djcA:
30.4		 3bexA-3djcA:
36.69
3bexB-3djcA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		6 / 11 ASN A   9
VAL A  64
GLY A 106
ASP A 108
THR A 135
ILE A 150
 None
 0.72A 3bexC-3djcA:
30.3
3bexD-3djcA:
30.3		 3bexC-3djcA:
36.69
3bexD-3djcA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		6 / 10 ASN A   9
VAL A  64
GLY A 106
ASP A 108
THR A 135
ILE A 150
 None
 0.72A 3bexC-3djcA:
30.3
3bexD-3djcA:
30.3		 3bexC-3djcA:
36.69
3bexD-3djcA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		6 / 10 ASN A   9
VAL A  64
GLY A 106
ASP A 108
THR A 135
ILE A 150
 None
 0.70A 3bexE-3djcA:
30.5
3bexF-3djcA:
30.5		 3bexE-3djcA:
36.69
3bexF-3djcA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		6 / 11 ASN A   9
VAL A  64
GLY A 106
ASP A 108
THR A 135
ILE A 150
 None
 0.71A 3bexE-3djcA:
30.5
3bexF-3djcA:
30.5		 3bexE-3djcA:
36.69
3bexF-3djcA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		6 / 11 ASN A   9
VAL A  64
GLY A 106
ASP A 108
THR A 135
ILE A 150
 None
 0.76A 3bf1A-3djcA:
30.3
3bf1B-3djcA:
30.4		 3bf1A-3djcA:
36.69
3bf1B-3djcA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		7 / 12 ASN A   9
VAL A  64
VAL A 105
GLY A 106
ASP A 108
THR A 135
ILE A 150
 None
 0.75A 3bf1A-3djcA:
30.3
3bf1B-3djcA:
30.4		 3bf1A-3djcA:
36.69
3bf1B-3djcA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		6 / 11 ASN A   9
VAL A  64
GLY A 106
ASP A 108
THR A 135
ILE A 150
 None
 0.72A 3bf1C-3djcA:
30.3
3bf1D-3djcA:
30.4		 3bf1C-3djcA:
36.69
3bf1D-3djcA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		6 / 11 ASN A   9
VAL A  64
GLY A 106
ASP A 108
THR A 135
ILE A 150
 None
 0.72A 3bf1C-3djcA:
30.3
3bf1D-3djcA:
30.4		 3bf1C-3djcA:
36.69
3bf1D-3djcA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		6 / 11 ASN A   9
VAL A  64
GLY A 106
ASP A 108
THR A 135
ILE A 150
 None
 0.71A 3bf1E-3djcA:
30.5
3bf1F-3djcA:
30.5		 3bf1E-3djcA:
36.69
3bf1F-3djcA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		6 / 11 ASN A   9
VAL A  64
GLY A 106
ASP A 108
THR A 135
ILE A 150
 None
 0.72A 3bf1E-3djcA:
30.5
3bf1F-3djcA:
30.5		 3bf1E-3djcA:
36.69
3bf1F-3djcA:
36.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		5 / 12 ALA A 115
ALA A 116
LEU A 220
VAL A 105
CYH A 137
 None
 0.94A 3fc6C-3djcA:
undetectable		 3fc6C-3djcA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		3 / 3 PHE A 136
TYR A 235
LEU A 146
 None
 0.61A 3keeB-3djcA:
undetectable		 3keeB-3djcA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		3 / 3 PHE A 136
TYR A 235
LEU A 146
 None
 0.47A 3sueB-3djcA:
undetectable		 3sueB-3djcA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		5 / 12 ALA A 115
ALA A 116
LEU A 220
VAL A 105
CYH A 137
 None
 0.94A 3uvvB-3djcA:
undetectable		 3uvvB-3djcA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		7 / 12 ASN A   9
VAL A  64
TYR A  99
GLY A 106
ASP A 108
THR A 135
ILE A 150
 None
 0.69A 4o5fA-3djcA:
25.7
4o5fB-3djcA:
25.7		 4o5fA-3djcA:
27.24
4o5fB-3djcA:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		7 / 12 ASN A   9
VAL A  64
TYR A  99
GLY A 106
ASP A 108
THR A 135
ILE A 150
 None
 0.69A 4o5fA-3djcA:
25.7
4o5fB-3djcA:
25.7		 4o5fA-3djcA:
27.24
4o5fB-3djcA:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		5 / 11 ASP A 108
ALA A 113
VAL A 127
THR A 135
ILE A 150
 None
 1.21A 4uuuA-3djcA:
undetectable
4uuuB-3djcA:
undetectable		 4uuuA-3djcA:
21.29
4uuuB-3djcA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		5 / 11 ASP A 108
ALA A 113
VAL A 127
THR A 135
ILE A 150
 None
 1.27A 4uuuB-3djcA:
undetectable		 4uuuB-3djcA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		7 / 12 ASN A   9
VAL A  64
TYR A  99
GLY A 106
ASP A 108
THR A 135
ILE A 150
 None
 0.74A 5b8hA-3djcA:
25.9
5b8hB-3djcA:
26.1		 5b8hA-3djcA:
27.15
5b8hB-3djcA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		7 / 12 ASN A   9
VAL A  64
TYR A  99
GLY A 106
ASP A 108
THR A 135
ILE A 150
 None
 0.75A 5b8hA-3djcA:
25.9
5b8hB-3djcA:
26.1		 5b8hA-3djcA:
27.15
5b8hB-3djcA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		4 / 4 THR A  34
LEU A  38
HIS A  28
GLY A  39
 None
 1.49A 5gwyA-3djcA:
undetectable		 5gwyA-3djcA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		4 / 9 HIS A  28
ILE A  12
TYR A  79
ILE A  61
 None
 0.78A 5vkqB-3djcA:
undetectable
5vkqC-3djcA:
undetectable		 5vkqB-3djcA:
9.39
5vkqC-3djcA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		5 / 12 ALA A 115
ALA A 116
LEU A 220
VAL A 105
CYH A 137
 None
 0.90A 5z12B-3djcA:
undetectable		 5z12B-3djcA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_0
(BETA-1 ADRENERGIC
RECEPTOR)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		5 / 12 VAL A 103
ASP A  69
VAL A  68
SER A  30
ASN A   9
 None
 1.48A 6h7lA-3djcA:
undetectable		 6h7lA-3djcA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 3djc TYPE III
PANTOTHENATE KINASE
(Legionella
pneumophila) 		5 / 12 VAL A 103
ASP A  69
VAL A  68
SER A  30
ASN A   9
 None
 1.48A 6h7lB-3djcA:
undetectable		 6h7lB-3djcA:
20.44