SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dkp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3dkp PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX52
(Homo
sapiens) 		5 / 12 ILE A 376
LEU A 205
PHE A 352
ILE A 196
PRO A 222
 None
 0.99A 1drfA-3dkpA:
undetectable		 1drfA-3dkpA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 3dkp PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX52
(Homo
sapiens) 		3 / 3 ASP A 321
PHE A 331
VAL A 317
 None
 0.74A 1kijB-3dkpA:
undetectable		 1kijB-3dkpA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)		 3dkp PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX52
(Homo
sapiens) 		5 / 11 LEU A 205
ASP A 155
ILE A 160
VAL A 374
ILE A 372
 None
 0.96A 1t3rB-3dkpA:
undetectable		 1t3rB-3dkpA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3dkp PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX52
(Homo
sapiens) 		5 / 10 VAL A 312
ILE A 307
THR A 291
ILE A 240
LEU A 315
 None
 1.11A 1z11D-3dkpA:
undetectable		 1z11D-3dkpA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 3dkp PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX52
(Homo
sapiens) 		5 / 12 ILE A 376
LEU A 205
PHE A 352
ILE A 196
PRO A 222
 None
 1.10A 2w3bA-3dkpA:
undetectable		 2w3bA-3dkpA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 3dkp PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX52
(Homo
sapiens) 		5 / 12 ILE A 376
LEU A 205
PHE A 352
ILE A 196
PRO A 222
 None
 1.06A 2w3bB-3dkpA:
undetectable		 2w3bB-3dkpA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 3dkp PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX52
(Homo
sapiens) 		5 / 12 ILE A 376
LEU A 205
PHE A 352
ILE A 196
PRO A 222
 None
 1.05A 2w3mA-3dkpA:
undetectable		 2w3mA-3dkpA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 3dkp PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX52
(Homo
sapiens) 		3 / 3 HIS A 266
HIS A 251
ILE A 265
 None
 0.76A 3u52A-3dkpA:
undetectable
3u52C-3dkpA:
undetectable		 3u52A-3dkpA:
18.95
3u52C-3dkpA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 3dkp PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX52
(Homo
sapiens) 		5 / 12 LEU A 205
ASP A 155
ILE A 160
VAL A 374
ILE A 372
 None
 0.82A 4dqbA-3dkpA:
undetectable		 4dqbA-3dkpA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 3dkp PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX52
(Homo
sapiens) 		5 / 11 ILE A 149
ILE A 191
PHE A 163
ALA A 218
VAL A 374
 None
 1.05A 4h1nA-3dkpA:
undetectable		 4h1nA-3dkpA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3dkp PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX52
(Homo
sapiens) 		5 / 12 ILE A 376
LEU A 205
PHE A 352
ILE A 196
PRO A 222
 None
 1.00A 4kfjB-3dkpA:
undetectable		 4kfjB-3dkpA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dkp PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX52
(Homo
sapiens) 		5 / 12 ILE A 376
LEU A 205
PHE A 352
ILE A 196
PRO A 222
 None
 1.03A 4m6kA-3dkpA:
undetectable		 4m6kA-3dkpA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3dkp PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX52
(Homo
sapiens) 		5 / 12 ASN A 370
ILE A 372
VAL A 151
HIS A 201
VAL A 198
 None
 1.18A 6j21A-3dkpA:
undetectable		 6j21A-3dkpA:
19.23