SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dkq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3dkq PKHD-TYPE
HYDROXYLASE
SBAL_3634
(Shewanella
baltica) 		4 / 6 PHE A  93
ASN A  85
ARG A 102
ASN A  99
 IMD  A 502 (-4.0A)
None
IMD  A 501 ( 4.7A)
None
 1.45A 1t9uA-3dkqA:
undetectable		 1t9uA-3dkqA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3dkq PKHD-TYPE
HYDROXYLASE
SBAL_3634
(Shewanella
baltica) 		4 / 6 ARG A  63
LEU A 119
ALA A 145
LEU A  17
 None
 0.89A 1ukbA-3dkqA:
undetectable		 1ukbA-3dkqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 3dkq PKHD-TYPE
HYDROXYLASE
SBAL_3634
(Shewanella
baltica) 		4 / 8 ARG A 110
LEU A 218
LEU A 224
LEU A  77
 None
 0.80A 2bfpC-3dkqA:
undetectable		 2bfpC-3dkqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 3dkq PKHD-TYPE
HYDROXYLASE
SBAL_3634
(Shewanella
baltica) 		4 / 6 ILE A  60
ARG A  63
LEU A  64
LEU A  17
 None
 0.89A 2rlfA-3dkqA:
undetectable
2rlfD-3dkqA:
undetectable		 2rlfA-3dkqA:
11.96
2rlfD-3dkqA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 3dkq PKHD-TYPE
HYDROXYLASE
SBAL_3634
(Shewanella
baltica) 		5 / 10 TYR A  87
HIS A  96
ASP A  98
HIS A 157
TRP A 173
 None
NI  A 500 (-3.4A)
NI  A 500 ( 2.4A)
NI  A 500 ( 3.4A)
None
 1.20A 3kcxA-3dkqA:
7.4		 3kcxA-3dkqA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 3dkq PKHD-TYPE
HYDROXYLASE
SBAL_3634
(Shewanella
baltica) 		3 / 3 ASN A  85
ALA A 169
ARG A 167
 None
 0.78A 3tj7C-3dkqA:
undetectable
3tj7D-3dkqA:
undetectable		 3tj7C-3dkqA:
22.18
3tj7D-3dkqA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3dkq PKHD-TYPE
HYDROXYLASE
SBAL_3634
(Shewanella
baltica) 		4 / 6 PHE A 118
GLY A 128
LEU A 130
VAL A 159
 None
None
IMD  A 502 (-4.8A)
IMD  A 502 (-4.9A)
 1.07A 4dubA-3dkqA:
undetectable		 4dubA-3dkqA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3dkq PKHD-TYPE
HYDROXYLASE
SBAL_3634
(Shewanella
baltica) 		5 / 8 ASN A  85
ALA A 170
PRO A  82
LEU A  21
LEU A 119
 None
 1.32A 4jjkA-3dkqA:
undetectable		 4jjkA-3dkqA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3dkq PKHD-TYPE
HYDROXYLASE
SBAL_3634
(Shewanella
baltica) 		4 / 8 TYR A 125
THR A 160
TYR A  87
LEU A 130
 None
None
None
IMD  A 502 (-4.8A)
 1.48A 5kxiA-3dkqA:
4.6
5kxiB-3dkqA:
4.7		 5kxiA-3dkqA:
21.27
5kxiB-3dkqA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3dkq PKHD-TYPE
HYDROXYLASE
SBAL_3634
(Shewanella
baltica) 		4 / 8 TYR A 125
THR A 160
TYR A  87
LEU A 130
 None
None
None
IMD  A 502 (-4.8A)
 1.49A 5kxiD-3dkqA:
5.2
5kxiE-3dkqA:
4.7		 5kxiD-3dkqA:
21.27
5kxiE-3dkqA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 3dkq PKHD-TYPE
HYDROXYLASE
SBAL_3634
(Shewanella
baltica) 		4 / 7 ARG A 179
ARG A 110
THR A 111
PRO A 152
 GOL  A 503 (-3.7A)
None
None
None
 1.49A 6a4iB-3dkqA:
undetectable		 6a4iB-3dkqA:
22.76