SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dl1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE
(Klebsiella
pneumoniae) 		5 / 12 PHE A  88
LEU A 130
VAL A 147
PHE A  73
VAL A  91
 None
 1.26A 1q23B-3dl1A:
undetectable		 1q23B-3dl1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE
(Klebsiella
pneumoniae) 		5 / 12 PHE A  88
LEU A 130
VAL A 147
PHE A  73
VAL A  91
 None
 1.27A 1q23C-3dl1A:
undetectable		 1q23C-3dl1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE
(Klebsiella
pneumoniae) 		5 / 10 PHE A  88
LEU A 130
VAL A 147
PHE A  73
VAL A  91
 None
 1.25A 1q23E-3dl1A:
undetectable		 1q23E-3dl1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE
(Klebsiella
pneumoniae) 		5 / 11 PHE A  88
LEU A 130
VAL A 147
PHE A  73
VAL A  91
 None
 1.18A 1q23F-3dl1A:
undetectable		 1q23F-3dl1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE
(Klebsiella
pneumoniae) 		5 / 12 PHE A  88
LEU A 130
VAL A 147
PHE A  73
VAL A  91
 None
 1.22A 1q23H-3dl1A:
undetectable
1q23I-3dl1A:
undetectable		 1q23H-3dl1A:
21.03
1q23I-3dl1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE
(Klebsiella
pneumoniae) 		5 / 11 PHE A  88
LEU A 130
VAL A 147
PHE A  73
VAL A  91
 None
 1.28A 1q23I-3dl1A:
undetectable		 1q23I-3dl1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE
(Klebsiella
pneumoniae) 		5 / 10 PHE A  88
LEU A 130
VAL A 147
PHE A  73
VAL A  91
 None
 1.22A 1q23K-3dl1A:
undetectable		 1q23K-3dl1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE
(Klebsiella
pneumoniae) 		3 / 3 ASP A 134
GLU A 212
TYR A 220
 None
 0.83A 1wsvA-3dl1A:
undetectable		 1wsvA-3dl1A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE
(Klebsiella
pneumoniae) 		5 / 10 ALA A  23
LEU A  78
LEU A  75
LEU A  29
LEU A  40
 None
 0.99A 2riwA-3dl1A:
undetectable
2riwB-3dl1A:
undetectable		 2riwA-3dl1A:
20.52
2riwB-3dl1A:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE
(Klebsiella
pneumoniae) 		5 / 10 GLN A 245
LEU A  78
LEU A  75
LEU A  29
LEU A  40
 None
 1.12A 2riwA-3dl1A:
undetectable
2riwB-3dl1A:
undetectable		 2riwA-3dl1A:
20.52
2riwB-3dl1A:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE
(Klebsiella
pneumoniae) 		5 / 10 ALA A  23
LEU A  78
LEU A  75
LEU A  29
LEU A  40
 None
 1.04A 2xn6A-3dl1A:
undetectable
2xn6B-3dl1A:
undetectable		 2xn6A-3dl1A:
20.51
2xn6B-3dl1A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE
(Klebsiella
pneumoniae) 		5 / 10 GLN A 245
LEU A  78
LEU A  75
LEU A  29
LEU A  40
 None
 1.16A 2xn6A-3dl1A:
undetectable
2xn6B-3dl1A:
undetectable		 2xn6A-3dl1A:
20.51
2xn6B-3dl1A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE
(Klebsiella
pneumoniae) 		5 / 10 ALA A  23
LEU A  78
LEU A  75
LEU A  29
LEU A  40
 None
 1.06A 2xn7A-3dl1A:
undetectable
2xn7B-3dl1A:
undetectable		 2xn7A-3dl1A:
20.51
2xn7B-3dl1A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE
(Klebsiella
pneumoniae) 		5 / 12 GLY A 143
ALA A 141
ASP A 140
VAL A 216
HIS A 149
 None
CL  A 267 ( 4.3A)
None
None
None
 1.01A 2yqzA-3dl1A:
undetectable		 2yqzA-3dl1A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE
(Klebsiella
pneumoniae) 		4 / 8 GLY A 143
ILE A 188
CYH A 213
PHE A 214
 None
 0.84A 3ko0O-3dl1A:
undetectable
3ko0Q-3dl1A:
undetectable		 3ko0O-3dl1A:
15.53
3ko0Q-3dl1A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE
(Klebsiella
pneumoniae) 		4 / 7 PRO A  97
ASP A 134
SER A 142
PHE A 144
 None
 1.28A 4ndnC-3dl1A:
undetectable		 4ndnC-3dl1A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE
(Klebsiella
pneumoniae) 		4 / 7 PRO A  97
ASP A 134
SER A 142
PHE A 144
 None
 1.21A 4odjA-3dl1A:
undetectable		 4odjA-3dl1A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE
(Klebsiella
pneumoniae) 		4 / 7 PRO A  97
ASP A 134
SER A 142
PHE A 144
 None
 1.29A 5a1iA-3dl1A:
undetectable		 5a1iA-3dl1A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE
(Klebsiella
pneumoniae) 		4 / 5 LEU A 146
PHE A  73
ILE A 135
ILE A  69
 None
 1.02A 5dzk4-3dl1A:
undetectable
5dzkg-3dl1A:
undetectable
5dzkm-3dl1A:
undetectable
5dzkn-3dl1A:
undetectable		 5dzk4-3dl1A:
1.36
5dzkg-3dl1A:
22.26
5dzkm-3dl1A:
24.03
5dzkn-3dl1A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE
(Klebsiella
pneumoniae) 		4 / 7 PRO A  97
ASP A 134
SER A 142
PHE A 144
 None
 1.31A 6g6rA-3dl1A:
undetectable		 6g6rA-3dl1A:
20.70