SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dla'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 571
ASP A 568
ASP A 482
LEU A 488
GLY A 489
 None
 1.39A 1d4fA-3dlaA:
3.2		 1d4fA-3dlaA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  91
GLY A  94
VAL A 115
ILE A 148
ILE A 110
 None
 1.02A 1hpvA-3dlaA:
undetectable		 1hpvA-3dlaA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 212
GLU A 177
GLU A  52
GLU A 132
 None
ONL  A 800 (-3.4A)
None
ONL  A 800 (-4.8A)
 1.06A 1knyA-3dlaA:
undetectable
1knyB-3dlaA:
undetectable		 1knyA-3dlaA:
15.97
1knyB-3dlaA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 132
ASP A 212
GLU A 177
GLU A  52
 ONL  A 800 (-4.8A)
None
ONL  A 800 (-3.4A)
None
 1.15A 1knyA-3dlaA:
undetectable
1knyB-3dlaA:
undetectable		 1knyA-3dlaA:
15.97
1knyB-3dlaA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 110
LEU A 200
LEU A  47
ASN A 105
ASP A 178
 None
 1.30A 1mrlA-3dlaA:
undetectable
1mrlB-3dlaA:
undetectable		 1mrlA-3dlaA:
14.26
1mrlB-3dlaA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 5 GLU A 252
LEU A 257
ASP A 273
LEU A 319
 None
 1.09A 1n13B-3dlaA:
undetectable
1n13C-3dlaA:
undetectable		 1n13B-3dlaA:
10.46
1n13C-3dlaA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 257
ASP A 273
LEU A 319
GLU A 252
 None
 1.07A 1n13I-3dlaA:
undetectable
1n13L-3dlaA:
undetectable		 1n13I-3dlaA:
7.28
1n13L-3dlaA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  80
LEU A 200
VAL A 108
GLY A  94
ALA A  95
 None
 1.25A 1pxxB-3dlaA:
undetectable		 1pxxB-3dlaA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A  80
LEU A 200
VAL A 108
GLY A  94
ALA A  95
 None
 1.25A 1pxxD-3dlaA:
undetectable		 1pxxD-3dlaA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 200
ALA A 231
VAL A 173
LEU A  47
HIS A  19
 None
 1.25A 1qabE-3dlaA:
undetectable		 1qabE-3dlaA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 166
LEU A  47
VAL A  14
ILE A 250
LEU A 279
 None
 1.10A 1s19A-3dlaA:
undetectable		 1s19A-3dlaA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 651
LEU A 483
GLY A 648
ARG A 285
ASP A 568
 None
 1.02A 2bm9F-3dlaA:
undetectable		 2bm9F-3dlaA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 234
GLY A 236
ARG A 262
VAL A 267
GLY A 266
 None
 0.98A 2qe6B-3dlaA:
2.3		 2qe6B-3dlaA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 10 ILE A 513
ALA A 376
ILE A 521
LEU A 538
THR A 480
 None
 1.24A 2w3aB-3dlaA:
undetectable		 2w3aB-3dlaA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 189
GLY A 193
ARG A 283
PHE A 308
 None
 0.90A 2wq5A-3dlaA:
undetectable		 2wq5A-3dlaA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 475
ILE A 469
ALA A 380
LEU A 478
VAL A 504
 None
 0.95A 2yqzB-3dlaA:
5.1		 2yqzB-3dlaA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 538
VAL A 537
SER A 522
ILE A 517
ALA A 418
 None
 1.24A 2zbzA-3dlaA:
undetectable		 2zbzA-3dlaA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 8 THR A 145
ARG A 100
ASP A 158
LEU A 159
 GOL  A 804 (-4.8A)
GOL  A 804 ( 4.8A)
None
None
 1.02A 2zw9A-3dlaA:
3.1		 2zw9A-3dlaA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 SER A 281
SER A 570
ILE A 672
ASP A 275
GLU A 277
 None
 1.39A 3aocC-3dlaA:
undetectable		 3aocC-3dlaA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 10 TYR A   7
THR A 276
LEU A 310
LEU A 166
VAL A 196
 None
 1.25A 3lxiA-3dlaA:
undetectable		 3lxiA-3dlaA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 11 TYR A   7
THR A 276
LEU A 310
LEU A 166
VAL A 196
 None
 1.25A 3lxiB-3dlaA:
undetectable		 3lxiB-3dlaA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		3 / 3 GLN A 498
THR A 492
LEU A 466
 None
NXX  A 680 (-4.0A)
None
 0.55A 3ondA-3dlaA:
3.7		 3ondA-3dlaA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		3 / 3 GLN A 498
THR A 492
LEU A 466
 None
NXX  A 680 (-4.0A)
None
 0.56A 3ondB-3dlaA:
4.8		 3ondB-3dlaA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 198
SER A 186
MET A 179
LEU A 171
ALA A  16
 None
 1.20A 3ou6C-3dlaA:
3.5		 3ou6C-3dlaA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 198
SER A 186
MET A 179
LEU A 171
ALA A  16
 None
 1.19A 3ou7C-3dlaA:
undetectable		 3ou7C-3dlaA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 6 SER A 221
TYR A 228
ALA A 222
ARG A 218
 None
 1.07A 3ravA-3dlaA:
undetectable		 3ravA-3dlaA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 6 SER A 221
TYR A 228
ALA A 222
ARG A 218
 None
 1.07A 3rd0A-3dlaA:
undetectable		 3rd0A-3dlaA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		3 / 3 PHE A 180
SER A 203
SER A 201
 ONL  A 800 (-4.0A)
ONL  A 800 ( 4.6A)
ONL  A 800 ( 4.2A)
 0.95A 3ufgB-3dlaA:
undetectable		 3ufgB-3dlaA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 649
ALA A 650
ALA A 487
ARG A 636
 None
 0.80A 3ur0B-3dlaA:
undetectable		 3ur0B-3dlaA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 9 TYR A   7
THR A 276
LEU A 310
LEU A 166
VAL A 196
 None
 1.26A 4c9kA-3dlaA:
undetectable		 4c9kA-3dlaA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 8 TYR A   7
THR A 276
LEU A 310
LEU A 166
VAL A 196
 None
 1.27A 4c9nA-3dlaA:
undetectable		 4c9nA-3dlaA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 10 TYR A   7
THR A 276
LEU A 310
LEU A 166
VAL A 196
 None
 1.26A 4c9nB-3dlaA:
undetectable		 4c9nB-3dlaA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 9 TYR A   7
THR A 276
LEU A 310
LEU A 166
VAL A 196
 None
 1.27A 4c9pA-3dlaA:
undetectable		 4c9pA-3dlaA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 11 HIS A 515
GLN A 514
ILE A 542
GLY A 370
ASN A 411
 None
 1.44A 4fglA-3dlaA:
undetectable
4fglB-3dlaA:
undetectable		 4fglA-3dlaA:
16.01
4fglB-3dlaA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 139
GLY A 156
LEU A 159
VAL A 173
 None
 0.90A 4fgzA-3dlaA:
undetectable		 4fgzA-3dlaA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 482
ASN A 505
ALA A 506
ASP A 568
 None
 1.01A 4mdaA-3dlaA:
undetectable		 4mdaA-3dlaA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 158
ALA A 107
VAL A 173
PHE A 155
GLY A 117
 None
 1.23A 4mm4B-3dlaA:
undetectable		 4mm4B-3dlaA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 171
THR A 195
LEU A 160
SER A 186
 None
 1.17A 4qknA-3dlaA:
undetectable		 4qknA-3dlaA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 5 GLN A 458
LEU A 461
ASP A 497
ASP A 482
 None
None
NXX  A 680 (-2.7A)
None
 1.10A 4qtuD-3dlaA:
3.0		 4qtuD-3dlaA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 6 ASN A 199
GLU A 177
GLU A 132
TYR A  58
 None
ONL  A 800 (-3.4A)
ONL  A 800 (-4.8A)
GOL  A 805 (-4.5A)
 1.23A 4twdG-3dlaA:
undetectable
4twdH-3dlaA:
undetectable		 4twdG-3dlaA:
18.39
4twdH-3dlaA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 155
GLY A 139
TYR A 104
ALA A 137
 None
 1.29A 4yshB-3dlaA:
undetectable		 4yshB-3dlaA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 220
SER A 219
GLN A 247
MET A 249
GLU A 259
 None
 1.48A 4zj8A-3dlaA:
undetectable		 4zj8A-3dlaA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 8 GLN A 347
ILE A 513
ASP A 372
GLY A 507
 None
 1.06A 5hwaA-3dlaA:
undetectable		 5hwaA-3dlaA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 159
ARG A 305
ILE A 306
PHE A 161
 None
 1.32A 5kirB-3dlaA:
0.4		 5kirB-3dlaA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 571
ASP A 568
TRP A 592
ALA A 565
 None
 1.12A 5nwvA-3dlaA:
undetectable		 5nwvA-3dlaA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OAJ_E_TKTE601_1
()		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 237
CYH A 176
TYR A  58
ARG A 209
 None
ONL  A 800 (-1.6A)
GOL  A 805 (-4.5A)
ONL  A 800 ( 4.8A)
 1.13A 5oajD-3dlaA:
0.0
5oajE-3dlaA:
0.0		 5oajD-3dlaA:
17.38
5oajE-3dlaA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 225
ALA A 190
LEU A 191
LEU A 197
 None
 0.82A 5vkqA-3dlaA:
2.0
5vkqD-3dlaA:
2.0		 5vkqA-3dlaA:
17.44
5vkqD-3dlaA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 197
LEU A 225
ALA A 190
LEU A 191
 None
 0.81A 5vkqA-3dlaA:
2.0
5vkqB-3dlaA:
undetectable		 5vkqA-3dlaA:
17.44
5vkqB-3dlaA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 197
LEU A 225
ALA A 190
LEU A 191
 None
 0.81A 5vkqB-3dlaA:
2.0
5vkqC-3dlaA:
2.0		 5vkqB-3dlaA:
17.44
5vkqC-3dlaA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 197
LEU A 225
ALA A 190
LEU A 191
 None
 0.82A 5vkqC-3dlaA:
2.0
5vkqD-3dlaA:
2.0		 5vkqC-3dlaA:
17.44
5vkqD-3dlaA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		3 / 3 LYS A 414
ASN A 411
SER A 536
 None
 1.14A 5yw0A-3dlaA:
undetectable		 5yw0A-3dlaA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 116
VAL A 109
ALA A  46
ALA A 163
LEU A 171
 None
 1.14A 6h1lB-3dlaA:
undetectable		 6h1lB-3dlaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 8 ASP A  42
ARG A  38
HIS A  41
ASP A  35
 None
 1.24A 6mn4C-3dlaA:
undetectable		 6mn4C-3dlaA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 273
LEU A 320
ARG A 597
 None
 0.91A 7dfrA-3dlaA:
undetectable		 7dfrA-3dlaA:
13.46