SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dlc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1I9G_A_SAMA301_0 (HYPOTHETICAL PROTEIN RV2118C)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 12	GLY A 50 GLY A 52 ALA A 55 LEU A 56 ASP A 100	SAM A 220 (-3.5A) SAM A 220 (-3.2A) SAM A 220 ( 4.9A) None SAM A 220 (-3.2A)	0.49A	1i9gA-3dlcA: 15.5	1i9gA-3dlcA: 21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1K6C_B_MK1B902_2 (POL POLYPROTEIN)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 12	ASP A 72 GLY A 52 ASP A 48 VAL A 101 GLY A 118	SAM A 220 (-2.9A) SAM A 220 (-3.2A) SAM A 220 ( 4.9A) SAM A 220 ( 4.2A) SAM A 220 (-4.7A)	0.93A	1k6cB-3dlcA: undetectable	1k6cB-3dlcA: 18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIA_A_SAMA293_0 (GLYCINE N-METHYLTRANSFERASE)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 12	GLY A 52 SER A 74 MET A 77 GLY A 118 SER A 119	SAM A 220 (-3.2A) GOL A 222 ( 3.2A) SAM A 220 ( 3.8A) SAM A 220 (-4.7A) SAM A 220 (-2.8A)	0.97A	1kiaA-3dlcA: 15.3	1kiaA-3dlcA: 21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NBI_C_SAMC2293_0 (GLYCINE N-METHYLTRANSFERASE)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 12	GLY A 52 SER A 74 MET A 77 GLY A 118 SER A 119	SAM A 220 (-3.2A) GOL A 222 ( 3.2A) SAM A 220 ( 3.8A) SAM A 220 (-4.7A) SAM A 220 (-2.8A)	0.94A	1nbiC-3dlcA: 15.2	1nbiC-3dlcA: 20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NBI_D_SAMD3293_0 (GLYCINE N-METHYLTRANSFERASE)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 12	GLY A 52 SER A 74 MET A 77 GLY A 118 SER A 119	SAM A 220 (-3.2A) GOL A 222 ( 3.2A) SAM A 220 ( 3.8A) SAM A 220 (-4.7A) SAM A 220 (-2.8A)	0.94A	1nbiD-3dlcA: 15.2	1nbiD-3dlcA: 20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UPF_B_URFB999_1 (URACIL PHOSPHORIBOSYLTRANSF ERASE)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	4 / 7	TYR A 197 ILE A 210 ILE A 208 PHE A 185	None	0.77A	1upfB-3dlcA: undetectable	1upfB-3dlcA: 21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1VPT_A_SAMA400_0 (VP39)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 12	ILE A 49 GLY A 50 PRO A 53 GLY A 54 VAL A 101	None SAM A 220 (-3.5A) None None SAM A 220 ( 4.2A)	1.00A	1vptA-3dlcA: 6.8	1vptA-3dlcA: 20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2G72_B_SAMB2002_1 (PHENYLETHANOLAMINE N-METHYLTRANSFERASE)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	4 / 7	GLY A 52 TYR A 28 ASP A 72 ASP A 100	SAM A 220 (-3.2A) SAM A 220 (-4.5A) SAM A 220 (-2.9A) SAM A 220 (-3.2A)	0.85A	2g72B-3dlcA: 12.8	2g72B-3dlcA: 23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NYU_A_SAMA201_1 (PUTATIVE RIBOSOMAL RNA METHYLTRANSFERASE 2)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	4 / 4	PRO A 53 ASP A 72 ASP A 100 ASP A 48	None SAM A 220 (-2.9A) SAM A 220 (-3.2A) SAM A 220 ( 4.9A)	1.11A	2nyuA-3dlcA: 10.7	2nyuA-3dlcA: 21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q5K_A_AB1A201_2 (PROTEASE)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 12	ASP A 72 GLY A 52 ASP A 48 VAL A 101 GLY A 118	SAM A 220 (-2.9A) SAM A 220 (-3.2A) SAM A 220 ( 4.9A) SAM A 220 ( 4.2A) SAM A 220 (-4.7A)	0.94A	2q5kB-3dlcA: undetectable	2q5kB-3dlcA: 18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2R5P_B_MK1B902_2 (PROTEASE)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 12	ASP A 72 GLY A 52 ASP A 48 VAL A 101 GLY A 118	SAM A 220 (-2.9A) SAM A 220 (-3.2A) SAM A 220 ( 4.9A) SAM A 220 ( 4.2A) SAM A 220 (-4.7A)	0.90A	2r5pB-3dlcA: undetectable	2r5pB-3dlcA: 19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YVL_D_SAMD603_0 (HYPOTHETICAL PROTEIN)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 12	GLY A 50 GLY A 52 ALA A 55 LEU A 56 ASP A 100	SAM A 220 (-3.5A) SAM A 220 (-3.2A) SAM A 220 ( 4.9A) None SAM A 220 (-3.2A)	0.38A	2yvlD-3dlcA: 14.6	2yvlD-3dlcA: 24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZUL_A_SAMA376_0 (PROBABLE RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 12	GLY A 50 GLY A 52 ALA A 55 LEU A 56 VAL A 101	SAM A 220 (-3.5A) SAM A 220 (-3.2A) SAM A 220 ( 4.9A) None SAM A 220 ( 4.2A)	0.80A	2zulA-3dlcA: 11.4	2zulA-3dlcA: 19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A7E_A_SAMA216_1 (CATECHOL O-METHYLTRANSFERASE)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	4 / 6	SER A 119 ILE A 47 ILE A 68 ASP A 72	SAM A 220 (-2.8A) None None SAM A 220 (-2.9A)	0.98A	3a7eA-3dlcA: 12.9	3a7eA-3dlcA: 21.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3DLC_A_SAMA220_0 (PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	12 / 12	PHE A 8 TYR A 28 GLY A 50 GLY A 52 PHE A 73 SER A 74 ASP A 100 VAL A 101 HIS A 102 ARG A 117 SER A 119 TRP A 123	SAM A 220 ( 3.7A) SAM A 220 (-4.5A) SAM A 220 (-3.5A) SAM A 220 (-3.2A) SAM A 220 ( 3.4A) GOL A 222 ( 3.2A) SAM A 220 (-3.2A) SAM A 220 ( 4.2A) SAM A 220 ( 4.7A) SAM A 220 (-4.0A) SAM A 220 (-2.8A) None	0.00A	3dlcA-3dlcA: 42.6	3dlcA-3dlcA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3DLC_A_SAMA220_0 (PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 12	PHE A 122 TYR A 28 GLY A 50 VAL A 101 HIS A 102	None SAM A 220 (-4.5A) SAM A 220 (-3.5A) SAM A 220 ( 4.2A) SAM A 220 ( 4.7A)	1.29A	3dlcA-3dlcA: 42.6	3dlcA-3dlcA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DMF_A_SAMA388_0 (PROBABLE RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 12	GLY A 50 GLY A 52 ALA A 55 ASP A 100 VAL A 101	SAM A 220 (-3.5A) SAM A 220 (-3.2A) SAM A 220 ( 4.9A) SAM A 220 (-3.2A) SAM A 220 ( 4.2A)	0.71A	3dmfA-3dlcA: 11.3	3dmfA-3dlcA: 19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DMH_A_SAMA384_0 (PROBABLE RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 12	GLY A 50 GLY A 52 ALA A 55 LEU A 56 VAL A 101	SAM A 220 (-3.5A) SAM A 220 (-3.2A) SAM A 220 ( 4.9A) None SAM A 220 ( 4.2A)	0.74A	3dmhA-3dlcA: 11.3	3dmhA-3dlcA: 19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G2O_A_SAMA500_0 (PCZA361.24)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 12	GLY A 52 LEU A 56 LEU A 71 SER A 74 GLY A 118	SAM A 220 (-3.2A) None None GOL A 222 ( 3.2A) SAM A 220 (-4.7A)	0.63A	3g2oA-3dlcA: 16.1	3g2oA-3dlcA: 19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G2O_B_SAMB600_0 (PCZA361.24)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 12	GLY A 52 LEU A 56 LEU A 71 ASP A 100 GLY A 118	SAM A 220 (-3.2A) None None SAM A 220 (-3.2A) SAM A 220 (-4.7A)	0.64A	3g2oB-3dlcA: 17.0	3g2oB-3dlcA: 19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXW_B_017B200_1 (HIV-1 PROTEASE)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 10	ASP A 72 GLY A 52 ASP A 48 VAL A 101 GLY A 118	SAM A 220 (-2.9A) SAM A 220 (-3.2A) SAM A 220 ( 4.9A) SAM A 220 ( 4.2A) SAM A 220 (-4.7A)	1.03A	3oxwA-3dlcA: undetectable	3oxwA-3dlcA: 18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3R6W_A_NFZA214_1 (FMN-DEPENDENT NADH-AZOREDUCTASE 1)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 10	PHE A 130 PHE A 185 PHE A 206 GLY A 118 ASN A 176	None None None SAM A 220 (-4.7A) None	1.22A	3r6wA-3dlcA: undetectable 3r6wB-3dlcA: undetectable	3r6wA-3dlcA: 23.14 3r6wB-3dlcA: 23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ACB_C_DXCC1478_0 (TRANSLATION ELONGATION FACTOR SELB)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	4 / 6	SER A 116 ASP A 48 THR A 143 ILE A 145	None SAM A 220 ( 4.9A) None None	0.94A	4acbC-3dlcA: undetectable	4acbC-3dlcA: 19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B17_A_SAMA1358_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE M)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 12	GLY A 50 PRO A 53 GLY A 54 ASP A 72 ASP A 100	SAM A 220 (-3.5A) None None SAM A 220 (-2.9A) SAM A 220 (-3.2A)	0.54A	4b17A-3dlcA: 10.9	4b17A-3dlcA: 20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B17_A_SAMA1358_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE M)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 12	SER A 20 GLY A 50 PRO A 53 ASP A 72 ASP A 100	None SAM A 220 (-3.5A) None SAM A 220 (-2.9A) SAM A 220 (-3.2A)	1.04A	4b17A-3dlcA: 10.9	4b17A-3dlcA: 20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DM8_B_REAB1501_1 (RETINOIC ACID RECEPTOR BETA)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 12	PHE A 66 ALA A 59 SER A 64 GLY A 148 LEU A 154	None	0.92A	4dm8B-3dlcA: undetectable	4dm8B-3dlcA: 19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FOR_A_FLPA711_1 (LACTOTRANSFERRIN)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	4 / 7	GLY A 150 ASN A 34 TYR A 144 GLY A 146	None	0.84A	4forA-3dlcA: undetectable	4forA-3dlcA: 21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IV8_A_SAMA301_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE, PUTATIVE)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 12	GLY A 50 GLY A 52 ASP A 72 MET A 77 ASP A 100	SAM A 220 (-3.5A) SAM A 220 (-3.2A) SAM A 220 (-2.9A) SAM A 220 ( 3.8A) SAM A 220 (-3.2A)	0.64A	4iv8A-3dlcA: 16.1	4iv8A-3dlcA: 23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IV8_B_SAMB301_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE, PUTATIVE)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 12	GLY A 50 GLY A 52 ASP A 72 MET A 77 ASP A 100	SAM A 220 (-3.5A) SAM A 220 (-3.2A) SAM A 220 (-2.9A) SAM A 220 ( 3.8A) SAM A 220 (-3.2A)	0.67A	4iv8B-3dlcA: 16.3	4iv8B-3dlcA: 23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KIC_B_SAMB401_1 (METHYLTRANSFERASE MPPJ)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	3 / 3	ARG A 117 ASP A 72 ASP A 100	SAM A 220 (-4.0A) SAM A 220 (-2.9A) SAM A 220 (-3.2A)	0.50A	4kicB-3dlcA: 15.2	4kicB-3dlcA: 19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NJV_A_RITA500_2 (PROTEASE)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 11	ASP A 72 GLY A 52 ASP A 48 VAL A 101 GLY A 118	SAM A 220 (-2.9A) SAM A 220 (-3.2A) SAM A 220 ( 4.9A) SAM A 220 ( 4.2A) SAM A 220 (-4.7A)	1.02A	4njvB-3dlcA: undetectable	4njvB-3dlcA: 18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QDJ_A_SAMA301_0 (MAGNESIUM-PROTOPORPH YRIN O-METHYLTRANSFERASE)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 12	PHE A 8 GLY A 50 GLY A 52 SER A 74 MET A 77	SAM A 220 ( 3.7A) SAM A 220 (-3.5A) SAM A 220 (-3.2A) GOL A 222 ( 3.2A) SAM A 220 ( 3.8A)	0.79A	4qdjA-3dlcA: 16.1	4qdjA-3dlcA: 24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5E72_A_SAMA400_1 (N2, N2-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	4 / 4	ASP A 48 GLY A 52 ASP A 72 ASP A 100	SAM A 220 ( 4.9A) SAM A 220 (-3.2A) SAM A 220 (-2.9A) SAM A 220 (-3.2A)	0.64A	5e72A-3dlcA: 14.0	5e72A-3dlcA: 18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GWX_A_SAMA301_0 (GLYCINE SARCOSINE N-METHYLTRANSFERASE)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 12	GLY A 52 SER A 74 MET A 77 GLY A 118 SER A 119	SAM A 220 (-3.2A) GOL A 222 ( 3.2A) SAM A 220 ( 3.8A) SAM A 220 (-4.7A) SAM A 220 (-2.8A)	1.05A	5gwxA-3dlcA: 16.6	5gwxA-3dlcA: 22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HIK_A_SAMA301_0 (GLYCINE SARCOSINE N-METHYLTRANSFERASE)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 12	GLY A 52 SER A 74 MET A 77 GLY A 118 SER A 119	SAM A 220 (-3.2A) GOL A 222 ( 3.2A) SAM A 220 ( 3.8A) SAM A 220 (-4.7A) SAM A 220 (-2.8A)	1.10A	5hikA-3dlcA: 16.4	5hikA-3dlcA: 22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M24_A_9CRA501_1 (RETINOIC ACID RECEPTOR GAMMA)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 12	ALA A 59 ILE A 35 SER A 64 GLY A 148 LEU A 154	None	1.06A	5m24A-3dlcA: undetectable	5m24A-3dlcA: 20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6IFT_A_SAMA301_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE A)	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	5 / 12	ILE A 49 GLY A 50 GLY A 52 ALA A 55 VAL A 101	None SAM A 220 (-3.5A) SAM A 220 (-3.2A) SAM A 220 ( 4.9A) SAM A 220 ( 4.2A)	0.80A	6iftA-3dlcA: 9.8	6iftA-3dlcA: 24.41

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1I9G_A_SAMA301_0","HYPOTHETICAL PROTEIN RV2118C","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"GLY A  50;GLY A  52;ALA A  55;LEU A  56;ASP A 100","SAM A 220 (-3.5A);SAM A 220 (-3.2A);SAM A 220 ( 4.9A);None;SAM A 220 (-3.2A)","0.49A","1i9gA-3dlcA:15.5","1i9gA-3dlcA:21.74"],["1K6C_B_MK1B902_2","POL POLYPROTEIN","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"ASP A  72;GLY A  52;ASP A  48;VAL A 101;GLY A 118","SAM A 220 (-2.9A);SAM A 220 (-3.2A);SAM A 220 ( 4.9A);SAM A 220 ( 4.2A);SAM A 220 (-4.7A)","0.93A","1k6cB-3dlcA:undetectable","1k6cB-3dlcA:18.75"],["1KIA_A_SAMA293_0","GLYCINE N-METHYLTRANSFERASE","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"GLY A  52;SER A  74;MET A  77;GLY A 118;SER A 119","SAM A 220 (-3.2A);GOL A 222 ( 3.2A);SAM A 220 ( 3.8A);SAM A 220 (-4.7A);SAM A 220 (-2.8A)","0.97A","1kiaA-3dlcA:15.3","1kiaA-3dlcA:21.62"],["1NBI_C_SAMC2293_0","GLYCINE N-METHYLTRANSFERASE","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"GLY A  52;SER A  74;MET A  77;GLY A 118;SER A 119","SAM A 220 (-3.2A);GOL A 222 ( 3.2A);SAM A 220 ( 3.8A);SAM A 220 (-4.7A);SAM A 220 (-2.8A)","0.94A","1nbiC-3dlcA:15.2","1nbiC-3dlcA:20.95"],["1NBI_D_SAMD3293_0","GLYCINE N-METHYLTRANSFERASE","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"GLY A  52;SER A  74;MET A  77;GLY A 118;SER A 119","SAM A 220 (-3.2A);GOL A 222 ( 3.2A);SAM A 220 ( 3.8A);SAM A 220 (-4.7A);SAM A 220 (-2.8A)","0.94A","1nbiD-3dlcA:15.2","1nbiD-3dlcA:20.95"],["1UPF_B_URFB999_1","URACIL PHOSPHORIBOSYLTRANSFERASE","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",4,"TYR A 197;ILE A 210;ILE A 208;PHE A 185","None","0.77A","1upfB-3dlcA:undetectable","1upfB-3dlcA:21.85"],["1VPT_A_SAMA400_0","VP39","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"ILE A  49;GLY A  50;PRO A  53;GLY A  54;VAL A 101","None;SAM A 220 (-3.5A);None;None;SAM A 220 ( 4.2A)","1.00A","1vptA-3dlcA:6.8","1vptA-3dlcA:20.06"],["2G72_B_SAMB2002_1","PHENYLETHANOLAMINE N-METHYLTRANSFERASE","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",4,"GLY A  52;TYR A  28;ASP A  72;ASP A 100","SAM A 220 (-3.2A);SAM A 220 (-4.5A);SAM A 220 (-2.9A);SAM A 220 (-3.2A)","0.85A","2g72B-3dlcA:12.8","2g72B-3dlcA:23.73"],["2NYU_A_SAMA201_1","PUTATIVE RIBOSOMAL RNA METHYLTRANSFERASE 2","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",4,"PRO A  53;ASP A  72;ASP A 100;ASP A  48","None;SAM A 220 (-2.9A);SAM A 220 (-3.2A);SAM A 220 ( 4.9A)","1.11A","2nyuA-3dlcA:10.7","2nyuA-3dlcA:21.77"],["2Q5K_A_AB1A201_2","PROTEASE;PROTEASE","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"ASP A  72;GLY A  52;ASP A  48;VAL A 101;GLY A 118","SAM A 220 (-2.9A);SAM A 220 (-3.2A);SAM A 220 ( 4.9A);SAM A 220 ( 4.2A);SAM A 220 (-4.7A)","0.94A","2q5kB-3dlcA:undetectable","2q5kB-3dlcA:18.35"],["2R5P_B_MK1B902_2","PROTEASE","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"ASP A  72;GLY A  52;ASP A  48;VAL A 101;GLY A 118","SAM A 220 (-2.9A);SAM A 220 (-3.2A);SAM A 220 ( 4.9A);SAM A 220 ( 4.2A);SAM A 220 (-4.7A)","0.90A","2r5pB-3dlcA:undetectable","2r5pB-3dlcA:19.17"],["2YVL_D_SAMD603_0","HYPOTHETICAL PROTEIN","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"GLY A  50;GLY A  52;ALA A  55;LEU A  56;ASP A 100","SAM A 220 (-3.5A);SAM A 220 (-3.2A);SAM A 220 ( 4.9A);None;SAM A 220 (-3.2A)","0.38A","2yvlD-3dlcA:14.6","2yvlD-3dlcA:24.00"],["2ZUL_A_SAMA376_0","PROBABLE RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"GLY A  50;GLY A  52;ALA A  55;LEU A  56;VAL A 101","SAM A 220 (-3.5A);SAM A 220 (-3.2A);SAM A 220 ( 4.9A);None;SAM A 220 ( 4.2A)","0.80A","2zulA-3dlcA:11.4","2zulA-3dlcA:19.90"],["3A7E_A_SAMA216_1","CATECHOL O-METHYLTRANSFERASE","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",4,"SER A 119;ILE A  47;ILE A  68;ASP A  72","SAM A 220 (-2.8A);None;None;SAM A 220 (-2.9A)","0.98A","3a7eA-3dlcA:12.9","3a7eA-3dlcA:21.77"],["3DLC_A_SAMA220_0","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",12,"PHE A   8;TYR A  28;GLY A  50;GLY A  52;PHE A  73;SER A  74;ASP A 100;VAL A 101;HIS A 102;ARG A 117;SER A 119;TRP A 123","SAM A 220 ( 3.7A);SAM A 220 (-4.5A);SAM A 220 (-3.5A);SAM A 220 (-3.2A);SAM A 220 ( 3.4A);GOL A 222 ( 3.2A);SAM A 220 (-3.2A);SAM A 220 ( 4.2A);SAM A 220 ( 4.7A);SAM A 220 (-4.0A);SAM A 220 (-2.8A);None","0.00A","3dlcA-3dlcA:42.6","3dlcA-3dlcA:100.00"],["3DLC_A_SAMA220_0","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"PHE A 122;TYR A  28;GLY A  50;VAL A 101;HIS A 102","None;SAM A 220 (-4.5A);SAM A 220 (-3.5A);SAM A 220 ( 4.2A);SAM A 220 ( 4.7A)","1.29A","3dlcA-3dlcA:42.6","3dlcA-3dlcA:100.00"],["3DMF_A_SAMA388_0","PROBABLE RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"GLY A  50;GLY A  52;ALA A  55;ASP A 100;VAL A 101","SAM A 220 (-3.5A);SAM A 220 (-3.2A);SAM A 220 ( 4.9A);SAM A 220 (-3.2A);SAM A 220 ( 4.2A)","0.71A","3dmfA-3dlcA:11.3","3dmfA-3dlcA:19.90"],["3DMH_A_SAMA384_0","PROBABLE RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"GLY A  50;GLY A  52;ALA A  55;LEU A  56;VAL A 101","SAM A 220 (-3.5A);SAM A 220 (-3.2A);SAM A 220 ( 4.9A);None;SAM A 220 ( 4.2A)","0.74A","3dmhA-3dlcA:11.3","3dmhA-3dlcA:19.90"],["3G2O_A_SAMA500_0","PCZA361.24","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"GLY A  52;LEU A  56;LEU A  71;SER A  74;GLY A 118","SAM A 220 (-3.2A);None;None;GOL A 222 ( 3.2A);SAM A 220 (-4.7A)","0.63A","3g2oA-3dlcA:16.1","3g2oA-3dlcA:19.80"],["3G2O_B_SAMB600_0","PCZA361.24","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"GLY A  52;LEU A  56;LEU A  71;ASP A 100;GLY A 118","SAM A 220 (-3.2A);None;None;SAM A 220 (-3.2A);SAM A 220 (-4.7A)","0.64A","3g2oB-3dlcA:17.0","3g2oB-3dlcA:19.80"],["3OXW_B_017B200_1","HIV-1 PROTEASE;HIV-1 PROTEASE","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"ASP A  72;GLY A  52;ASP A  48;VAL A 101;GLY A 118","SAM A 220 (-2.9A);SAM A 220 (-3.2A);SAM A 220 ( 4.9A);SAM A 220 ( 4.2A);SAM A 220 (-4.7A)","1.03A","3oxwA-3dlcA:undetectable","3oxwA-3dlcA:18.35"],["3R6W_A_NFZA214_1","FMN-DEPENDENT NADH-AZOREDUCTASE 1;FMN-DEPENDENT NADH-AZOREDUCTASE 1","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"PHE A 130;PHE A 185;PHE A 206;GLY A 118;ASN A 176","None;None;None;SAM A 220 (-4.7A);None","1.22A","3r6wA-3dlcA:undetectable;3r6wB-3dlcA:undetectable","3r6wA-3dlcA:23.14;3r6wB-3dlcA:23.14"],["4ACB_C_DXCC1478_0","TRANSLATION ELONGATION FACTOR SELB","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",4,"SER A 116;ASP A  48;THR A 143;ILE A 145","None;SAM A 220 ( 4.9A);None;None","0.94A","4acbC-3dlcA:undetectable","4acbC-3dlcA:19.38"],["4B17_A_SAMA1358_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE M","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"GLY A  50;PRO A  53;GLY A  54;ASP A  72;ASP A 100","SAM A 220 (-3.5A);None;None;SAM A 220 (-2.9A);SAM A 220 (-3.2A)","0.54A","4b17A-3dlcA:10.9","4b17A-3dlcA:20.30"],["4B17_A_SAMA1358_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE M","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"SER A  20;GLY A  50;PRO A  53;ASP A  72;ASP A 100","None;SAM A 220 (-3.5A);None;SAM A 220 (-2.9A);SAM A 220 (-3.2A)","1.04A","4b17A-3dlcA:10.9","4b17A-3dlcA:20.30"],["4DM8_B_REAB1501_1","RETINOIC ACID RECEPTOR BETA","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"PHE A  66;ALA A  59;SER A  64;GLY A 148;LEU A 154","None","0.92A","4dm8B-3dlcA:undetectable","4dm8B-3dlcA:19.69"],["4FOR_A_FLPA711_1","LACTOTRANSFERRIN","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",4,"GLY A 150;ASN A  34;TYR A 144;GLY A 146","None","0.84A","4forA-3dlcA:undetectable","4forA-3dlcA:21.02"],["4IV8_A_SAMA301_0","PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE,PUTATIVE","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"GLY A  50;GLY A  52;ASP A  72;MET A  77;ASP A 100","SAM A 220 (-3.5A);SAM A 220 (-3.2A);SAM A 220 (-2.9A);SAM A 220 ( 3.8A);SAM A 220 (-3.2A)","0.64A","4iv8A-3dlcA:16.1","4iv8A-3dlcA:23.71"],["4IV8_B_SAMB301_0","PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE,PUTATIVE","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"GLY A  50;GLY A  52;ASP A  72;MET A  77;ASP A 100","SAM A 220 (-3.5A);SAM A 220 (-3.2A);SAM A 220 (-2.9A);SAM A 220 ( 3.8A);SAM A 220 (-3.2A)","0.67A","4iv8B-3dlcA:16.3","4iv8B-3dlcA:23.71"],["4KIC_B_SAMB401_1","METHYLTRANSFERASE MPPJ","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",3,"ARG A 117;ASP A  72;ASP A 100","SAM A 220 (-4.0A);SAM A 220 (-2.9A);SAM A 220 (-3.2A)","0.50A","4kicB-3dlcA:15.2","4kicB-3dlcA:19.89"],["4NJV_A_RITA500_2","PROTEASE;PROTEASE","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"ASP A  72;GLY A  52;ASP A  48;VAL A 101;GLY A 118","SAM A 220 (-2.9A);SAM A 220 (-3.2A);SAM A 220 ( 4.9A);SAM A 220 ( 4.2A);SAM A 220 (-4.7A)","1.02A","4njvB-3dlcA:undetectable","4njvB-3dlcA:18.26"],["4QDJ_A_SAMA301_0","MAGNESIUM-PROTOPORPHYRIN O-METHYLTRANSFERASE","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"PHE A   8;GLY A  50;GLY A  52;SER A  74;MET A  77","SAM A 220 ( 3.7A);SAM A 220 (-3.5A);SAM A 220 (-3.2A);GOL A 222 ( 3.2A);SAM A 220 ( 3.8A)","0.79A","4qdjA-3dlcA:16.1","4qdjA-3dlcA:24.42"],["5E72_A_SAMA400_1","N2, N2-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",4,"ASP A  48;GLY A  52;ASP A  72;ASP A 100","SAM A 220 ( 4.9A);SAM A 220 (-3.2A);SAM A 220 (-2.9A);SAM A 220 (-3.2A)","0.64A","5e72A-3dlcA:14.0","5e72A-3dlcA:18.77"],["5GWX_A_SAMA301_0","GLYCINE SARCOSINE N-METHYLTRANSFERASE","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"GLY A  52;SER A  74;MET A  77;GLY A 118;SER A 119","SAM A 220 (-3.2A);GOL A 222 ( 3.2A);SAM A 220 ( 3.8A);SAM A 220 (-4.7A);SAM A 220 (-2.8A)","1.05A","5gwxA-3dlcA:16.6","5gwxA-3dlcA:22.65"],["5HIK_A_SAMA301_0","GLYCINE SARCOSINE N-METHYLTRANSFERASE","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"GLY A  52;SER A  74;MET A  77;GLY A 118;SER A 119","SAM A 220 (-3.2A);GOL A 222 ( 3.2A);SAM A 220 ( 3.8A);SAM A 220 (-4.7A);SAM A 220 (-2.8A)","1.10A","5hikA-3dlcA:16.4","5hikA-3dlcA:22.65"],["5M24_A_9CRA501_1","RETINOIC ACID RECEPTOR GAMMA","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"ALA A  59;ILE A  35;SER A  64;GLY A 148;LEU A 154","None","1.06A","5m24A-3dlcA:undetectable","5m24A-3dlcA:20.61"],["6IFT_A_SAMA301_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE A","3dlc","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","Methanococcus maripaludis",5,"ILE A  49;GLY A  50;GLY A  52;ALA A  55;VAL A 101","None;SAM A 220 (-3.5A);SAM A 220 (-3.2A);SAM A 220 ( 4.9A);SAM A 220 ( 4.2A)","0.80A","6iftA-3dlcA:9.8","6iftA-3dlcA:24.41"]]