SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dlj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 3dlj BETA-ALA-HIS
DIPEPTIDASE
(Homo
sapiens) 		4 / 8 PHE A 473
ILE A 442
GLY A 466
PHE A 470
 None
 0.85A 1rtsA-3dljA:
undetectable		 1rtsA-3dljA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 3dlj BETA-ALA-HIS
DIPEPTIDASE
(Homo
sapiens) 		4 / 6 VAL A  12
LEU A 157
ARG A 155
PHE A 154
 None
 1.10A 1s8fB-3dljA:
3.0		 1s8fB-3dljA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3dlj BETA-ALA-HIS
DIPEPTIDASE
(Homo
sapiens) 		6 / 10 LEU A 145
PHE A 103
ILE A  88
LEU A  59
LEU A 107
ILE A 169
 None
 1.38A 1yi4A-3dljA:
undetectable		 1yi4A-3dljA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 3dlj BETA-ALA-HIS
DIPEPTIDASE
(Homo
sapiens) 		4 / 6 PHE A  23
ILE A  16
VAL A  12
ALA A 471
 None
 1.02A 2j5mA-3dljA:
undetectable		 2j5mA-3dljA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 3dlj BETA-ALA-HIS
DIPEPTIDASE
(Homo
sapiens) 		4 / 6 LEU A 107
MET A  52
LEU A  48
GLU A 173
 None
None
None
UNX  A2004 ( 3.2A)
 1.23A 2kuhA-3dljA:
undetectable		 2kuhA-3dljA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 3dlj BETA-ALA-HIS
DIPEPTIDASE
(Homo
sapiens) 		3 / 3 MET A 224
VAL A 266
GLU A 369
 None
 0.90A 2x9gA-3dljA:
undetectable		 2x9gA-3dljA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 3dlj BETA-ALA-HIS
DIPEPTIDASE
(Homo
sapiens) 		3 / 3 ARG A 342
ASP A 233
ASP A 231
 None
None
UNX  A2010 ( 4.8A)
 0.69A 3jayA-3dljA:
undetectable		 3jayA-3dljA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 3dlj BETA-ALA-HIS
DIPEPTIDASE
(Homo
sapiens) 		3 / 3 ARG A 342
ASP A 233
ASP A 231
 None
None
UNX  A2010 ( 4.8A)
 0.66A 3jb2A-3dljA:
undetectable		 3jb2A-3dljA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 3dlj BETA-ALA-HIS
DIPEPTIDASE
(Homo
sapiens) 		3 / 3 ARG A 342
ASP A 233
ASP A 231
 None
None
UNX  A2010 ( 4.8A)
 0.69A 3jb3A-3dljA:
undetectable		 3jb3A-3dljA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 3dlj BETA-ALA-HIS
DIPEPTIDASE
(Homo
sapiens) 		4 / 4 ASP A 139
ASP A 202
GLY A 445
THR A 214
 ZN  A2001 ( 2.4A)
ZN  A2002 ( 2.1A)
None
None
 1.33A 3tl9B-3dljA:
undetectable		 3tl9B-3dljA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 3dlj BETA-ALA-HIS
DIPEPTIDASE
(Homo
sapiens) 		5 / 12 ASN A 140
GLY A 445
GLY A 134
ASN A 455
GLN A 454
 ZN  A2002 ( 4.7A)
None
None
None
None
 1.25A 3v3oA-3dljA:
undetectable		 3v3oA-3dljA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 3dlj BETA-ALA-HIS
DIPEPTIDASE
(Homo
sapiens) 		4 / 5 ASP A 331
GLU A 327
GLY A 328
GLU A 332
 UNX  A2007 (-2.7A)
None
None
UNX  A2007 (-4.0A)
 1.14A 3w9tA-3dljA:
undetectable		 3w9tA-3dljA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 3dlj BETA-ALA-HIS
DIPEPTIDASE
(Homo
sapiens) 		4 / 6 ASP A 331
GLU A 327
GLY A 328
GLU A 332
 UNX  A2007 (-2.7A)
None
None
UNX  A2007 (-4.0A)
 1.14A 3w9tB-3dljA:
undetectable		 3w9tB-3dljA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 3dlj BETA-ALA-HIS
DIPEPTIDASE
(Homo
sapiens) 		4 / 5 ASP A 331
GLU A 327
GLY A 328
GLU A 332
 UNX  A2007 (-2.7A)
None
None
UNX  A2007 (-4.0A)
 1.14A 3w9tD-3dljA:
undetectable		 3w9tD-3dljA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 3dlj BETA-ALA-HIS
DIPEPTIDASE
(Homo
sapiens) 		4 / 6 ASP A 331
GLU A 327
GLY A 328
GLU A 332
 UNX  A2007 (-2.7A)
None
None
UNX  A2007 (-4.0A)
 1.13A 3w9tF-3dljA:
undetectable		 3w9tF-3dljA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3dlj BETA-ALA-HIS
DIPEPTIDASE
(Homo
sapiens) 		4 / 6 VAL A 364
VAL A 266
ILE A 264
LEU A 351
 None
 0.89A 4l1wB-3dljA:
undetectable		 4l1wB-3dljA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3dlj BETA-ALA-HIS
DIPEPTIDASE
(Homo
sapiens) 		4 / 6 ILE A 168
PHE A 167
ILE A 442
ILE A 427
 None
 0.63A 4o8fB-3dljA:
undetectable		 4o8fB-3dljA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 3dlj BETA-ALA-HIS
DIPEPTIDASE
(Homo
sapiens) 		5 / 11 HIS A 106
ASP A 139
GLU A 173
GLU A 174
HIS A 452
 ZN  A2002 (-3.2A)
ZN  A2001 ( 2.4A)
UNX  A2004 ( 3.2A)
ZN  A2001 (-2.1A)
ZN  A2001 (-3.2A)
 0.28A 4pqaA-3dljA:
32.5		 4pqaA-3dljA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 3dlj BETA-ALA-HIS
DIPEPTIDASE
(Homo
sapiens) 		3 / 3 ARG A 317
GLU A 279
TYR A 284
 None
 0.87A 4r29D-3dljA:
undetectable		 4r29D-3dljA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3dlj BETA-ALA-HIS
DIPEPTIDASE
(Homo
sapiens) 		5 / 12 GLU A 451
GLY A 142
ALA A 146
ILE A 464
ASP A 448
 None
 1.17A 4xe5A-3dljA:
undetectable		 4xe5A-3dljA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 3dlj BETA-ALA-HIS
DIPEPTIDASE
(Homo
sapiens) 		5 / 12 ALA A 407
GLU A 476
LEU A 402
MET A 418
LEU A 469
 None
 1.15A 4zn7A-3dljA:
undetectable		 4zn7A-3dljA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3dlj BETA-ALA-HIS
DIPEPTIDASE
(Homo
sapiens) 		5 / 12 VAL A 371
ASP A 370
SER A 256
PHE A 347
THR A 386
 None
 1.40A 5m54B-3dljA:
3.6		 5m54B-3dljA:
24.06