SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dlt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 3dlt ESTERASE D
(Lactobacillus
rhamnosus) 		5 / 10 THR A 222
LEU A 230
VAL A 234
VAL A  45
VAL A  18
 None
 1.20A 1o76A-3dltA:
undetectable		 1o76A-3dltA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 3dlt ESTERASE D
(Lactobacillus
rhamnosus) 		5 / 11 ALA A 196
GLY A 186
GLY A 183
ILE A 182
TYR A 214
 None
 1.17A 1pg2A-3dltA:
undetectable		 1pg2A-3dltA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3dlt ESTERASE D
(Lactobacillus
rhamnosus) 		5 / 11 PHE A 237
LEU A  38
VAL A  18
PHE A  91
VAL A 234
 None
 1.33A 1q23F-3dltA:
undetectable		 1q23F-3dltA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3dlt ESTERASE D
(Lactobacillus
rhamnosus) 		5 / 11 THR A 222
LEU A 230
VAL A 234
VAL A  45
VAL A  18
 None
 1.17A 2a1nA-3dltA:
undetectable		 2a1nA-3dltA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 3dlt ESTERASE D
(Lactobacillus
rhamnosus) 		4 / 6 TYR A  24
SER A 117
GLN A 184
ASP A  30
 None
 1.40A 2cl5B-3dltA:
undetectable		 2cl5B-3dltA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 3dlt ESTERASE D
(Lactobacillus
rhamnosus) 		5 / 10 THR A 222
LEU A 230
VAL A 234
VAL A  45
VAL A  18
 None
 1.24A 2cp4A-3dltA:
undetectable		 2cp4A-3dltA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9W_A_PXLA1197_1
(ASPARTATE
AMINOTRANSFERASE)		 3dlt ESTERASE D
(Lactobacillus
rhamnosus) 		5 / 11 GLU A  57
PRO A  58
LEU A  62
SER A 148
ASN A 139
 None
 1.26A 2z9wA-3dltA:
2.7		 2z9wA-3dltA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9W_B_PXLB1197_1
(ASPARTATE
AMINOTRANSFERASE)		 3dlt ESTERASE D
(Lactobacillus
rhamnosus) 		5 / 11 GLU A  57
PRO A  58
LEU A  62
SER A 148
ASN A 139
 None
 1.26A 2z9wB-3dltA:
undetectable		 2z9wB-3dltA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3dlt ESTERASE D
(Lactobacillus
rhamnosus) 		4 / 6 TYR A  24
SER A 117
GLN A 184
ASP A  30
 None
 1.38A 2zvjA-3dltA:
undetectable		 2zvjA-3dltA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 3dlt ESTERASE D
(Lactobacillus
rhamnosus) 		4 / 8 ASP A 163
GLY A 157
HIS A 125
TYR A  24
 None
None
BUA  A 246 (-3.5A)
None
 0.77A 3af0A-3dltA:
2.8		 3af0A-3dltA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 3dlt ESTERASE D
(Lactobacillus
rhamnosus) 		5 / 9 VAL A  19
VAL A  18
ILE A 110
GLY A 113
ALA A 100
 None
 1.17A 4fwdA-3dltA:
undetectable		 4fwdA-3dltA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3dlt ESTERASE D
(Lactobacillus
rhamnosus) 		4 / 8 THR A 222
VAL A 234
VAL A  45
VAL A  18
 None
 1.04A 4l4bA-3dltA:
undetectable		 4l4bA-3dltA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 3dlt ESTERASE D
(Lactobacillus
rhamnosus) 		4 / 7 ASP A 210
ASP A 233
TYR A 214
GLY A 183
 None
 0.94A 5hwaA-3dltA:
undetectable		 5hwaA-3dltA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 3dlt ESTERASE D
(Lactobacillus
rhamnosus) 		5 / 12 PHE A  99
ILE A 162
ALA A 166
ILE A 182
GLY A 114
 None
 0.90A 5veuB-3dltA:
undetectable		 5veuB-3dltA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 3dlt ESTERASE D
(Lactobacillus
rhamnosus) 		4 / 6 LEU A 199
LYS A 102
GLU A 105
LEU A 173
 None
 1.24A 5xooA-3dltA:
undetectable		 5xooA-3dltA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 3dlt ESTERASE D
(Lactobacillus
rhamnosus) 		4 / 8 ASN A  32
PHE A  91
LEU A  38
ALA A  35
 None
 0.79A 5y7pE-3dltA:
undetectable		 5y7pE-3dltA:
19.57