SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dm5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN
(Pyrococcus
furiosus) 		4 / 8 GLU A  55
ARG A  58
ARG A  59
GLU A  81
 None
 0.89A 1cmaA-3dm5A:
undetectable
1cmaB-3dm5A:
undetectable		 1cmaA-3dm5A:
14.02
1cmaB-3dm5A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN
(Pyrococcus
furiosus) 		4 / 8 LEU A 120
TYR A 123
MET A 105
VAL A 219
 None
 1.02A 1fduB-3dm5A:
undetectable		 1fduB-3dm5A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN
(Pyrococcus
furiosus) 		5 / 12 GLU A 282
ILE A 272
ASP A   4
LEU A   3
ALA A 253
 None
 1.33A 1hvyB-3dm5A:
undetectable		 1hvyB-3dm5A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN
(Pyrococcus
furiosus) 		5 / 12 ILE A  17
VAL A 290
LEU A  14
LEU A  39
ILE A  35
 None
 1.32A 1kqwA-3dm5A:
undetectable		 1kqwA-3dm5A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN
(Pyrococcus
furiosus) 		5 / 12 ILE A  17
VAL A 290
LEU A  14
LEU A  52
ILE A  56
 None
 1.09A 1kqwA-3dm5A:
undetectable		 1kqwA-3dm5A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN
(Pyrococcus
furiosus) 		5 / 10 LEU A   6
LEU A  39
ALA A  38
LEU A  48
VAL A  49
 None
 1.25A 2bxeA-3dm5A:
3.8		 2bxeA-3dm5A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN
(Pyrococcus
furiosus) 		5 / 10 LEU A  10
LEU A  39
ALA A  38
LEU A  48
VAL A  49
 None
 1.18A 2bxeA-3dm5A:
3.8		 2bxeA-3dm5A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN
(Pyrococcus
furiosus) 		5 / 8 TYR A 229
GLY A 266
THR A 265
ALA A 264
ALA A 263
 None
 1.39A 2ej3C-3dm5A:
undetectable		 2ej3C-3dm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN
(Pyrococcus
furiosus) 		4 / 7 ILE A 201
GLN A 206
ALA A 171
ILE A 211
 None
 0.84A 2xkwA-3dm5A:
undetectable		 2xkwA-3dm5A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN
(Pyrococcus
furiosus) 		5 / 12 GLY A 297
LEU A  14
SER A 291
TYR A  80
LEU A  83
 None
 1.36A 3bxoA-3dm5A:
3.7		 3bxoA-3dm5A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN
(Pyrococcus
furiosus) 		4 / 4 ILE A  28
GLN A  36
ILE A  17
LEU A  50
 None
 1.15A 3dzyD-3dm5A:
undetectable		 3dzyD-3dm5A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN
(Pyrococcus
furiosus) 		4 / 6 THR A 407
LEU A 330
GLN A 336
LEU A 337
 None
 1.20A 4nc3A-3dm5A:
2.7		 4nc3A-3dm5A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN
(Pyrococcus
furiosus) 		4 / 8 ILE A  75
LYS A  71
ILE A  17
ALA A  20
 None
 0.78A 4ou1A-3dm5A:
2.2		 4ou1A-3dm5A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN
(Pyrococcus
furiosus) 		4 / 7 LEU A  10
LEU A  83
LEU A   6
ALA A  38
 None
 0.63A 4z90F-3dm5A:
3.5
4z90G-3dm5A:
2.1
4z90H-3dm5A:
3.4
4z90J-3dm5A:
3.7		 4z90F-3dm5A:
21.43
4z90G-3dm5A:
21.43
4z90H-3dm5A:
21.43
4z90J-3dm5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN
(Pyrococcus
furiosus) 		5 / 12 LEU A  52
LEU A  10
GLY A 256
SER A 260
LEU A  87
 None
 1.19A 4zbrA-3dm5A:
3.7		 4zbrA-3dm5A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN
(Pyrococcus
furiosus) 		5 / 9 ASP A   4
GLY A   7
LEU A  10
LEU A  39
ALA A  38
 None
 0.89A 5dqfA-3dm5A:
4.1		 5dqfA-3dm5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN
(Pyrococcus
furiosus) 		5 / 10 ILE A 108
GLY A 192
THR A 190
LEU A 200
GLN A 227
 None
 1.32A 5fhzC-3dm5A:
undetectable		 5fhzC-3dm5A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN
(Pyrococcus
furiosus) 		5 / 12 ILE A 102
VAL A 133
GLU A 164
ALA A 143
VAL A 117
 None
 1.05A 5igjA-3dm5A:
undetectable		 5igjA-3dm5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN
(Pyrococcus
furiosus) 		5 / 12 ILE A 102
VAL A 133
GLU A 164
ALA A 143
VAL A 117
 None
 1.06A 5igtA-3dm5A:
undetectable		 5igtA-3dm5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN
(Pyrococcus
furiosus) 		4 / 7 ILE A 272
LEU A 249
ARG A 288
LEU A  87
 None
 0.91A 5xdqA-3dm5A:
2.2
5xdqJ-3dm5A:
undetectable		 5xdqA-3dm5A:
20.44
5xdqJ-3dm5A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN
(Pyrococcus
furiosus) 		3 / 3 HIS A  74
ARG A  59
ILE A  78
 None
 0.80A 6fgdA-3dm5A:
4.5		 6fgdA-3dm5A:
21.35