SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dm9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR
(Pyrococcus
furiosus) 		4 / 7 LEU B 210
VAL B 181
VAL B 179
TYR B 301
 None
 0.67A 1epbA-3dm9B:
undetectable		 1epbA-3dm9B:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR
(Pyrococcus
furiosus) 		4 / 8 LEU B 210
VAL B 181
VAL B 179
TYR B 301
 None
 0.80A 1epbB-3dm9B:
undetectable		 1epbB-3dm9B:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR
(Pyrococcus
furiosus) 		4 / 8 LEU B 223
ASN B 132
ASP B 212
THR B 139
 None
PO4  B 323 (-4.6A)
None
None
 1.03A 1ig3A-3dm9B:
2.4
1ig3B-3dm9B:
2.4		 1ig3A-3dm9B:
22.39
1ig3B-3dm9B:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR
(Pyrococcus
furiosus) 		4 / 7 ALA B 281
GLY B 279
GLY B 278
PHE B 312
 None
 0.74A 2c49B-3dm9B:
2.3		 2c49B-3dm9B:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR
(Pyrococcus
furiosus) 		5 / 12 GLY B 215
GLY B 243
GLY B 135
GLY B 133
THR B 270
 None
None
PO4  B 323 (-3.0A)
PO4  B 323 (-3.9A)
None
 0.71A 2oxtB-3dm9B:
2.0		 2oxtB-3dm9B:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR
(Pyrococcus
furiosus) 		5 / 12 ILE B 140
LEU B 210
LEU B 293
THR B 270
LEU B 304
 None
 0.94A 3a50D-3dm9B:
undetectable		 3a50D-3dm9B:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR
(Pyrococcus
furiosus) 		4 / 8 PRO B 190
ALA B 194
ALA B 157
ILE B 230
 None
 0.83A 3dtuC-3dm9B:
1.5
3dtuD-3dm9B:
undetectable		 3dtuC-3dm9B:
19.69
3dtuD-3dm9B:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR
(Pyrococcus
furiosus) 		5 / 10 ILE B 292
ILE B 284
VAL B 252
GLY B 248
LEU B 272
 None
None
MPD  B 501 ( 4.7A)
None
None
 1.10A 3elzC-3dm9B:
undetectable		 3elzC-3dm9B:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR
(Pyrococcus
furiosus) 		5 / 12 ILE B 292
ILE B 284
VAL B 252
LEU B   5
LEU B 272
 None
None
MPD  B 501 ( 4.7A)
None
None
 1.18A 3em0B-3dm9B:
undetectable		 3em0B-3dm9B:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR
(Pyrococcus
furiosus) 		4 / 7 GLY B 279
GLY B 278
LEU B 272
PHE B 312
 None
 0.70A 3o9mA-3dm9B:
2.5		 3o9mA-3dm9B:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR
(Pyrococcus
furiosus) 		4 / 7 ILE B  93
LEU B  78
GLU B  19
ALA B  49
 None
 0.91A 3r9tB-3dm9B:
undetectable		 3r9tB-3dm9B:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR
(Pyrococcus
furiosus) 		4 / 7 GLY B 133
SER B 134
PHE B 258
PHE B 241
 PO4  B 323 (-3.9A)
PO4  B 323 (-3.4A)
None
None
 0.83A 3v7pA-3dm9B:
undetectable		 3v7pA-3dm9B:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR
(Pyrococcus
furiosus) 		5 / 10 ILE B 284
GLY B 248
ASP B 275
GLY B 278
PHE B 312
 None
 1.26A 4bwlC-3dm9B:
undetectable		 4bwlC-3dm9B:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR
(Pyrococcus
furiosus) 		5 / 10 ALA B 194
ILE B 211
ILE B 140
LEU B 170
ILE B 156
 None
 1.24A 4dtaA-3dm9B:
2.0		 4dtaA-3dm9B:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR
(Pyrococcus
furiosus) 		4 / 8 THR B 213
THR B 137
GLY B 130
VAL B 242
 None
PO4  B 323 (-3.6A)
None
None
 0.82A 4qvvK-3dm9B:
undetectable
4qvvL-3dm9B:
undetectable		 4qvvK-3dm9B:
19.46
4qvvL-3dm9B:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR
(Pyrococcus
furiosus) 		4 / 8 THR B 213
THR B 137
GLY B 130
VAL B 242
 None
PO4  B 323 (-3.6A)
None
None
 0.82A 4qvvY-3dm9B:
undetectable
4qvvZ-3dm9B:
undetectable		 4qvvY-3dm9B:
19.46
4qvvZ-3dm9B:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR
(Pyrococcus
furiosus) 		5 / 12 GLY B 215
ARG B 163
THR B 213
LEU B 223
MET B 224
 None
PO4  B 323 ( 2.9A)
None
None
None
 1.41A 5fhzA-3dm9B:
undetectable		 5fhzA-3dm9B:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR
(Pyrococcus
furiosus) 		5 / 12 ALA B 245
LEU B 269
ALA B  60
GLY B 279
SER B 283
 None
 1.13A 5jglB-3dm9B:
2.4		 5jglB-3dm9B:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR
(Pyrococcus
furiosus) 		5 / 10 ILE B 240
ILE B 126
VAL B 242
THR B 139
ILE B 140
 None
 1.22A 5mzrA-3dm9B:
undetectable		 5mzrA-3dm9B:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR
(Pyrococcus
furiosus) 		5 / 12 ILE B 167
VAL B 181
ALA B 158
LEU B 147
LEU B 304
 None
 1.19A 6a7pB-3dm9B:
4.2		 6a7pB-3dm9B:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR
(Pyrococcus
furiosus) 		5 / 12 ILE B 240
THR B 137
VAL B 154
VAL B 208
ILE B 126
 None
PO4  B 323 (-3.6A)
None
None
None
 1.07A 6emuB-3dm9B:
2.9		 6emuB-3dm9B:
21.92