SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dmk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS
(Drosophila
melanogaster) 		3 / 3 VAL A 699
VAL A 742
TRP A 713
 None
 0.90A 1av2C-3dmkA:
undetectable
1av2D-3dmkA:
undetectable		 1av2C-3dmkA:
2.09
1av2D-3dmkA:
2.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS
(Drosophila
melanogaster) 		4 / 8 SER A 120
ASP A 175
GLU A 146
LYS A 178
 GOL  A 786 (-4.7A)
None
None
None
 1.22A 1mxgA-3dmkA:
undetectable		 1mxgA-3dmkA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS
(Drosophila
melanogaster) 		4 / 7 TYR A 180
ASN A 147
TYR A 148
LEU A 166
 None
 0.88A 1qzrA-3dmkA:
undetectable		 1qzrA-3dmkA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS
(Drosophila
melanogaster) 		4 / 7 TYR A 180
ASN A 147
TYR A 148
LEU A 166
 None
 0.81A 1qzrB-3dmkA:
undetectable		 1qzrB-3dmkA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS
(Drosophila
melanogaster) 		4 / 6 LEU A 430
ALA A 516
ASP A 439
TYR A 441
 None
 1.32A 2dpzA-3dmkA:
undetectable		 2dpzA-3dmkA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS
(Drosophila
melanogaster) 		4 / 6 TYR A 158
ASP A 155
THR A 142
GLU A 144
 None
 1.47A 2dttB-3dmkA:
undetectable
2dttC-3dmkA:
undetectable		 2dttB-3dmkA:
10.18
2dttC-3dmkA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS
(Drosophila
melanogaster) 		4 / 6 LEU A 457
TYR A 441
ILE A 435
GLY A 468
 None
 0.88A 2du8A-3dmkA:
undetectable		 2du8A-3dmkA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS
(Drosophila
melanogaster) 		4 / 6 LEU A 457
TYR A 441
ILE A 435
GLY A 468
 None
 0.89A 2du8B-3dmkA:
undetectable		 2du8B-3dmkA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS
(Drosophila
melanogaster) 		3 / 3 VAL A 699
VAL A 742
TRP A 713
 None
 0.76A 3l8lA-3dmkA:
undetectable
3l8lB-3dmkA:
undetectable		 3l8lA-3dmkA:
2.09
3l8lB-3dmkA:
2.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS
(Drosophila
melanogaster) 		3 / 3 ASP A 466
ASN A 465
SER A 461
 None
 0.94A 3lslA-3dmkA:
undetectable
3lslD-3dmkA:
undetectable		 3lslA-3dmkA:
15.98
3lslD-3dmkA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS
(Drosophila
melanogaster) 		3 / 3 GLU A 165
LEU A 234
LEU A 217
 None
 0.77A 3ohtA-3dmkA:
undetectable		 3ohtA-3dmkA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS
(Drosophila
melanogaster) 		3 / 3 GLU A 165
LEU A 234
LEU A 217
 None
 0.78A 3ohtB-3dmkA:
undetectable		 3ohtB-3dmkA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS
(Drosophila
melanogaster) 		4 / 5 HIS A 483
LEU A 430
TRP A 428
ASP A 466
 None
 1.18A 4aqlA-3dmkA:
undetectable		 4aqlA-3dmkA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS
(Drosophila
melanogaster) 		4 / 8 ILE A  36
TRP A  38
PHE A   6
GLU A  25
 None
 1.08A 4cx7C-3dmkA:
undetectable
4cx7D-3dmkA:
undetectable		 4cx7C-3dmkA:
20.60
4cx7D-3dmkA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS
(Drosophila
melanogaster) 		3 / 3 TYR A 441
HIS A 463
ARG A 440
 None
 1.13A 4htfA-3dmkA:
undetectable		 4htfA-3dmkA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS
(Drosophila
melanogaster) 		3 / 3 ARG A  94
GLU A 381
PHE A 372
 None
 0.95A 4kszA-3dmkA:
undetectable		 4kszA-3dmkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS
(Drosophila
melanogaster) 		5 / 12 TRP A  38
GLY A  47
ASP A  48
ALA A  45
TYR A  80
 None
 1.07A 4lg1A-3dmkA:
undetectable		 4lg1A-3dmkA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS
(Drosophila
melanogaster) 		3 / 3 HIS A 167
TRP A 140
SER A 270
 GOL  A 786 (-3.8A)
None
GOL  A 786 (-3.5A)
 1.00A 4lrhD-3dmkA:
undetectable		 4lrhD-3dmkA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS
(Drosophila
melanogaster) 		4 / 8 VAL A 290
SER A 293
GLY A 295
ALA A 237
 None
 0.88A 4m48A-3dmkA:
undetectable		 4m48A-3dmkA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS
(Drosophila
melanogaster) 		3 / 3 SER A 360
ALA A 326
VAL A 327
 None
 0.62A 4o2bA-3dmkA:
undetectable		 4o2bA-3dmkA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS
(Drosophila
melanogaster) 		3 / 3 SER A 360
ALA A 326
VAL A 327
 None
 0.68A 4o2bC-3dmkA:
undetectable		 4o2bC-3dmkA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS
(Drosophila
melanogaster) 		4 / 7 SER A 730
ILE A 733
LYS A 728
VAL A 742
 None
 1.17A 4tvtA-3dmkA:
undetectable		 4tvtA-3dmkA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS
(Drosophila
melanogaster) 		4 / 5 PHE A  63
ILE A  24
GLN A  78
ARG A  53
 None
 0.98A 5jm4A-3dmkA:
undetectable		 5jm4A-3dmkA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS
(Drosophila
melanogaster) 		4 / 4 PHE A  63
ILE A  24
GLN A  78
ARG A  53
 None
 0.99A 5jm4B-3dmkA:
undetectable		 5jm4B-3dmkA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS
(Drosophila
melanogaster) 		5 / 12 VAL A 373
ASP A  15
HIS A  97
PRO A 336
GLY A 334
 None
 1.49A 6gnfA-3dmkA:
undetectable		 6gnfA-3dmkA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS
(Drosophila
melanogaster) 		5 / 12 VAL A 373
ASP A  15
HIS A  97
PRO A 336
GLY A 334
 None
 1.50A 6gnfC-3dmkA:
undetectable		 6gnfC-3dmkA:
21.29