SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dmm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3dmm T-CELL SURFACE
GLYCOPROTEIN CD8
BETA CHAIN
(Mus
musculus) 		3 / 3 VAL D  63
VAL D  57
SER D  50
 None
 0.74A 3n8xB-3dmmD:
undetectable		 3n8xB-3dmmD:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3dmm T-CELL SURFACE
GLYCOPROTEIN CD8
BETA CHAIN
(Mus
musculus) 		3 / 3 PHE D  93
VAL D  86
ILE D  83
 None
 0.53A 4emaA-3dmmD:
undetectable		 4emaA-3dmmD:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3dmm T-CELL SURFACE
GLYCOPROTEIN CD8
ALPHA CHAIN
(Mus
musculus) 		4 / 5 TYR C  55
GLN C  34
GLY C  35
SER C  58
 None
 1.20A 4fu8A-3dmmC:
undetectable		 4fu8A-3dmmC:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 3dmm T-CELL SURFACE
GLYCOPROTEIN CD8
ALPHA CHAIN
T-CELL SURFACE
GLYCOPROTEIN CD8
BETA CHAIN
(Mus
musculus;
Mus
musculus) 		5 / 12 TYR C 111
GLY D  60
ASP D  64
ILE D  69
VAL D  57
 None
 0.99A 5dpdB-3dmmC:
undetectable		 5dpdB-3dmmC:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3dmm T-CELL SURFACE
GLYCOPROTEIN CD8
BETA CHAIN
(Mus
musculus) 		3 / 3 LEU D 112
ASN D  68
LEU D  48
 None
 0.74A 6exiD-3dmmD:
undetectable		 6exiD-3dmmD:
16.00