SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dmn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3dmn PUTATIVE DNA
HELICASE
(Lactobacillus
plantarum) 		5 / 12 THR A 608
ILE A 733
VAL A 713
ILE A 604
LEU A 743
 None
ACT  A   6 (-4.3A)
None
None
None
 1.11A 1z9hD-3dmnA:
undetectable		 1z9hD-3dmnA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3dmn PUTATIVE DNA
HELICASE
(Lactobacillus
plantarum) 		5 / 11 ALA A 737
LEU A 743
VAL A 713
ILE A 611
LEU A 730
 None
 1.23A 3fl9C-3dmnA:
undetectable		 3fl9C-3dmnA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3dmn PUTATIVE DNA
HELICASE
(Lactobacillus
plantarum) 		5 / 8 ASN A 720
ALA A 716
LEU A 753
LEU A 730
TRP A 714
 ACT  A   4 ( 4.1A)
None
None
None
ACT  A  10 (-4.1A)
 1.22A 4jjkA-3dmnA:
3.3		 4jjkA-3dmnA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 3dmn PUTATIVE DNA
HELICASE
(Lactobacillus
plantarum) 		6 / 12 VAL A 711
CYH A 734
ILE A 660
LEU A 730
LEU A 743
ALA A 716
 None
None
ACT  A   6 ( 4.9A)
None
None
None
 1.43A 4p65F-3dmnA:
undetectable
4p65H-3dmnA:
undetectable
4p65K-3dmnA:
undetectable
4p65L-3dmnA:
undetectable		 4p65F-3dmnA:
11.80
4p65H-3dmnA:
11.80
4p65K-3dmnA:
7.79
4p65L-3dmnA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3dmn PUTATIVE DNA
HELICASE
(Lactobacillus
plantarum) 		5 / 12 HIS A 758
VAL A 630
LEU A 753
ALA A 754
PRO A 751
 None
 1.23A 4yhaE-3dmnA:
undetectable		 4yhaE-3dmnA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_A_EZLA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3dmn PUTATIVE DNA
HELICASE
(Lactobacillus
plantarum) 		5 / 10 HIS A 758
VAL A 630
LEU A 753
ALA A 754
PRO A 751
 None
 1.28A 5tt3A-3dmnA:
undetectable		 5tt3A-3dmnA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_C_EZLC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3dmn PUTATIVE DNA
HELICASE
(Lactobacillus
plantarum) 		5 / 10 HIS A 758
VAL A 630
LEU A 753
ALA A 754
PRO A 751
 None
 1.31A 5tt3C-3dmnA:
undetectable		 5tt3C-3dmnA:
19.42