SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dmp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Burkholderia
pseudomallei) 		5 / 12 GLY A  89
VAL A  83
ALA A 207
LEU A 204
PHE A  35
 None
 0.79A 1gs4A-3dmpA:
undetectable		 1gs4A-3dmpA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Burkholderia
pseudomallei) 		5 / 10 GLY A 104
VAL A  81
LEU A 151
LEU A 126
ALA A  79
 None
 1.25A 1pbcA-3dmpA:
undetectable		 1pbcA-3dmpA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Burkholderia
pseudomallei) 		3 / 3 ARG A 102
ARG A 129
ILE A  98
 None
 0.69A 1uobA-3dmpA:
undetectable		 1uobA-3dmpA:
23.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Burkholderia
pseudomallei) 		5 / 5 MET A 137
ALA A 139
TYR A 199
ILE A 200
ASP A 206
 None
 0.64A 1upfA-3dmpA:
26.1		 1upfA-3dmpA:
37.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Burkholderia
pseudomallei) 		5 / 7 MET A 137
ALA A 139
TYR A 199
ILE A 200
ASP A 206
 None
 0.54A 1upfB-3dmpA:
25.9		 1upfB-3dmpA:
37.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Burkholderia
pseudomallei) 		5 / 5 MET A 137
ALA A 139
TYR A 199
ILE A 200
ASP A 206
 None
 0.60A 1upfC-3dmpA:
26.1		 1upfC-3dmpA:
37.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_D_URFD999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Burkholderia
pseudomallei) 		4 / 4 MET A 137
ALA A 139
TYR A 199
ILE A 200
 None
 0.48A 1upfD-3dmpA:
25.4		 1upfD-3dmpA:
37.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Burkholderia
pseudomallei) 		4 / 7 LEU A 151
PHE A 163
LEU A 123
SER A  91
 None
 0.94A 1wrlE-3dmpA:
undetectable
1wrlF-3dmpA:
undetectable		 1wrlE-3dmpA:
17.35
1wrlF-3dmpA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Burkholderia
pseudomallei) 		4 / 5 LEU A 123
GLY A 104
HIS A 105
ILE A 106
 None
 0.83A 1xf1A-3dmpA:
undetectable		 1xf1A-3dmpA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Burkholderia
pseudomallei) 		4 / 6 LEU A 123
GLY A 104
HIS A 105
ILE A 106
 None
 0.82A 1xf1B-3dmpA:
undetectable		 1xf1B-3dmpA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Burkholderia
pseudomallei) 		5 / 12 LEU A 164
ALA A 168
LEU A 204
ARG A  26
MET A  90
 None
 1.21A 1ya3A-3dmpA:
undetectable		 1ya3A-3dmpA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Burkholderia
pseudomallei) 		5 / 12 LEU A 164
ALA A 168
LEU A 204
ARG A  26
MET A  90
 None
 1.39A 1ya3B-3dmpA:
undetectable		 1ya3B-3dmpA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Burkholderia
pseudomallei) 		5 / 12 LEU A 164
ALA A 168
LEU A 204
ARG A  26
MET A  90
 None
 1.42A 2aa5B-3dmpA:
undetectable		 2aa5B-3dmpA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Burkholderia
pseudomallei) 		5 / 12 LEU A 164
ALA A 168
LEU A 204
ARG A  26
MET A  90
 None
 1.38A 2oaxC-3dmpA:
undetectable		 2oaxC-3dmpA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Burkholderia
pseudomallei) 		5 / 12 LEU A 164
ALA A 168
LEU A 204
ARG A  26
MET A  90
 None
 1.38A 2oaxD-3dmpA:
undetectable		 2oaxD-3dmpA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Burkholderia
pseudomallei) 		5 / 12 LEU A 164
ALA A 168
LEU A 204
ARG A  26
MET A  90
 None
 1.39A 2oaxE-3dmpA:
undetectable		 2oaxE-3dmpA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Burkholderia
pseudomallei) 		3 / 3 TYR A  48
LEU A 185
LYS A 184
 None
 0.71A 3sueD-3dmpA:
undetectable		 3sueD-3dmpA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Burkholderia
pseudomallei) 		5 / 12 LEU A 164
ALA A 168
LEU A 204
ARG A  26
MET A  90
 None
 1.38A 3vhuA-3dmpA:
undetectable		 3vhuA-3dmpA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Burkholderia
pseudomallei) 		3 / 3 ARG A   6
PHE A   7
PRO A   8
 None
 0.65A 3zoaB-3dmpA:
undetectable		 3zoaB-3dmpA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Burkholderia
pseudomallei) 		4 / 5 ILE A  42
ALA A 188
HIS A  24
ARG A  26
 None
 1.29A 4ac9B-3dmpA:
3.4
4ac9C-3dmpA:
3.6		 4ac9B-3dmpA:
19.22
4ac9C-3dmpA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Burkholderia
pseudomallei) 		4 / 5 ILE A  42
ALA A 188
HIS A  20
ARG A  26
 None
 1.19A 4acaB-3dmpA:
3.2
4acaC-3dmpA:
3.6		 4acaB-3dmpA:
19.22
4acaC-3dmpA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Burkholderia
pseudomallei) 		4 / 5 ILE A  42
ALA A 188
HIS A  24
ARG A  26
 None
 1.31A 4acaB-3dmpA:
3.2
4acaC-3dmpA:
3.6		 4acaB-3dmpA:
19.22
4acaC-3dmpA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Burkholderia
pseudomallei) 		4 / 6 LEU A  94
ILE A 130
MET A 162
THR A  51
 None
 0.87A 4do3B-3dmpA:
undetectable		 4do3B-3dmpA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Burkholderia
pseudomallei) 		4 / 7 GLY A 205
LEU A 185
PHE A 176
ASP A 191
 None
 0.67A 5hieB-3dmpA:
undetectable		 5hieB-3dmpA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Burkholderia
pseudomallei) 		4 / 8 ILE A  80
LEU A  54
ILE A  73
LEU A 164
 None
 0.89A 5ieoA-3dmpA:
undetectable		 5ieoA-3dmpA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Burkholderia
pseudomallei) 		4 / 5 GLN A   3
ASP A   4
SER A   5
ARG A   6
 None
 1.28A 5w4zA-3dmpA:
undetectable		 5w4zA-3dmpA:
17.84