SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dms'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		4 / 8 GLY A 308
ALA A 284
THR A 303
ILE A 311
 None
 0.75A 1gtnP-3dmsA:
undetectable
1gtnQ-3dmsA:
undetectable		 1gtnP-3dmsA:
11.24
1gtnQ-3dmsA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		4 / 7 THR A 303
SER A 226
THR A 228
VAL A 230
 None
 0.68A 1ictD-3dmsA:
undetectable		 1ictD-3dmsA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		5 / 12 ILE A  43
GLY A 323
VAL A 353
ALA A 317
GLY A 342
 None
 1.17A 1kiaB-3dmsA:
undetectable		 1kiaB-3dmsA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		5 / 12 ILE A  43
GLY A 323
VAL A 353
ALA A 317
GLY A 342
 None
 1.16A 1nbiA-3dmsA:
undetectable		 1nbiA-3dmsA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		4 / 6 PHE A 395
ASN A 354
ILE A 322
GLY A 323
 None
 0.93A 1oniD-3dmsA:
1.9
1oniF-3dmsA:
1.9		 1oniD-3dmsA:
17.53
1oniF-3dmsA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		5 / 11 ASN A 117
GLY A  73
ASP A  37
ILE A  34
THR A  90
 None
 1.29A 2f9wA-3dmsA:
undetectable
2f9wB-3dmsA:
undetectable		 2f9wA-3dmsA:
21.28
2f9wB-3dmsA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		5 / 11 ILE A  34
GLY A  38
THR A 343
LEU A 116
GLY A 103
 None
 1.40A 2fn1A-3dmsA:
undetectable		 2fn1A-3dmsA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		5 / 12 PRO A 271
ALA A 246
THR A 208
GLN A 217
ILE A 216
 None
 1.24A 2jjpA-3dmsA:
undetectable		 2jjpA-3dmsA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		4 / 6 ARG A 397
TYR A 352
THR A 392
ALA A 396
 None
 1.14A 2ql8A-3dmsA:
undetectable
2ql8B-3dmsA:
2.2		 2ql8A-3dmsA:
14.75
2ql8B-3dmsA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		5 / 11 ILE A 178
ALA A 169
ILE A 200
VAL A 177
THR A 195
 None
 1.25A 2w3aA-3dmsA:
undetectable		 2w3aA-3dmsA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		5 / 10 TYR A 352
ASP A  42
ILE A  43
ALA A 348
VAL A  46
 None
 1.33A 3ay0A-3dmsA:
undetectable		 3ay0A-3dmsA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		5 / 10 TYR A 347
GLY A 349
ASP A  42
ILE A  43
VAL A  46
 None
 1.30A 3ay0B-3dmsA:
undetectable		 3ay0B-3dmsA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		3 / 3 SER A 312
GLU A 338
ASP A 309
 None
 0.87A 3bwmA-3dmsA:
undetectable		 3bwmA-3dmsA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		5 / 12 HIS A 341
GLY A  36
GLY A  40
LEU A 105
LEU A 116
 None
 0.95A 3cjtO-3dmsA:
undetectable		 3cjtO-3dmsA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		5 / 10 LEU A 250
GLY A 256
ALA A 257
ILE A 220
VAL A 212
 None
 1.02A 3nu6B-3dmsA:
undetectable		 3nu6B-3dmsA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		3 / 3 GLU A 383
PHE A 136
GLN A 134
 None
 1.02A 3r55A-3dmsA:
undetectable		 3r55A-3dmsA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		4 / 6 ALA A  72
ILE A  34
LEU A 105
ALA A 119
 None
 0.91A 3r9sA-3dmsA:
undetectable		 3r9sA-3dmsA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		3 / 3 PRO A 104
ASP A  37
GLU A  35
 None
 0.87A 3v4tC-3dmsA:
undetectable		 3v4tC-3dmsA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		4 / 8 THR A 303
SER A 226
THR A 228
VAL A 230
 None
 0.59A 4ik7B-3dmsA:
undetectable		 4ik7B-3dmsA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		4 / 5 GLY A 327
ALA A 339
PHE A 337
GLU A 358
 None
 0.93A 4m93B-3dmsA:
undetectable
4m93C-3dmsA:
undetectable		 4m93B-3dmsA:
20.15
4m93C-3dmsA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		3 / 3 PRO A  32
MET A  68
TYR A  97
 None
 0.94A 4qa0B-3dmsA:
3.0		 4qa0B-3dmsA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		3 / 3 PRO A  32
MET A  68
TYR A  97
 None
 1.00A 4qa0A-3dmsA:
2.9		 4qa0A-3dmsA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		3 / 3 PRO A  32
MET A  68
TYR A  97
 None
 1.05A 4qa2B-3dmsA:
2.9		 4qa2B-3dmsA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		5 / 12 GLY A  36
PHE A 395
ILE A 386
GLY A 321
THR A 343
 None
 1.09A 4ze2A-3dmsA:
undetectable		 4ze2A-3dmsA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		5 / 12 GLY A  36
PHE A 395
ILE A 386
GLY A 321
THR A 343
 None
 1.09A 5eskA-3dmsA:
0.5		 5eskA-3dmsA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		5 / 12 GLY A  36
PHE A 395
ILE A 386
GLY A 321
THR A 343
 None
 1.07A 5eslA-3dmsA:
undetectable		 5eslA-3dmsA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		5 / 10 TYR A 135
PHE A 395
SER A 141
GLY A 321
VAL A 391
 None
 1.26A 5i6xA-3dmsA:
undetectable		 5i6xA-3dmsA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		5 / 9 LEU A 250
GLY A 256
ALA A 257
ILE A 220
VAL A 212
 None
 1.02A 5kr0B-3dmsA:
undetectable		 5kr0B-3dmsA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		5 / 11 GLY A 247
ALA A 249
ALA A 251
ILE A 216
VAL A 212
 None
 1.02A 5yk2A-3dmsA:
undetectable		 5yk2A-3dmsA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_D_9F2D400_2
(BETA-LACTAMASE)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		4 / 4 CYH A 129
ILE A 133
PRO A 326
THR A 303
 None
 1.44A 6b68D-3dmsA:
0.0		 6b68D-3dmsA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		4 / 9 VAL A 118
VAL A 203
SER A 204
ASP A 160
 None
 0.97A 6c2mD-3dmsA:
undetectable		 6c2mD-3dmsA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		4 / 4 HIS A 368
VAL A  98
LEU A  23
ALA A 335
 None
 1.21A 6d8pB-3dmsA:
4.7		 6d8pB-3dmsA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 3dms ISOCITRATE
DEHYDROGENASE [NADP]
(Burkholderia
pseudomallei) 		4 / 6 TYR A 298
VAL A 278
VAL A 227
THR A 228
 None
 1.36A 6f32B-3dmsA:
undetectable		 6f32B-3dmsA:
20.08