SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dmy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 10 LEU A 226
MET A 171
ILE A 180
HIS A 222
LEU A 247
 None
 1.48A 1a52A-3dmyA:
undetectable		 1a52A-3dmyA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 10 LEU A 226
MET A 171
ILE A 180
HIS A 222
LEU A 247
 None
 1.45A 1a52B-3dmyA:
undetectable		 1a52B-3dmyA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		3 / 3 ARG A 321
THR A 453
VAL A 479
 None
 0.99A 1hxbA-3dmyA:
undetectable		 1hxbA-3dmyA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 11 GLY A 182
LEU A 169
HIS A 222
LEU A 508
PRO A 505
 None
 1.46A 1mjqA-3dmyA:
undetectable
1mjqB-3dmyA:
undetectable		 1mjqA-3dmyA:
13.02
1mjqB-3dmyA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 10 GLY A 182
LEU A 169
HIS A 222
LEU A 508
PRO A 505
 None
 1.46A 1mjqG-3dmyA:
undetectable
1mjqH-3dmyA:
undetectable		 1mjqG-3dmyA:
13.02
1mjqH-3dmyA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 10 LEU A 226
MET A 171
ILE A 180
HIS A 222
LEU A 247
 None
 1.46A 1qkuA-3dmyA:
undetectable		 1qkuA-3dmyA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 10 LEU A 226
MET A 171
ILE A 180
HIS A 222
LEU A 247
 None
 1.47A 1qkuB-3dmyA:
undetectable		 1qkuB-3dmyA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 10 LEU A 226
MET A 171
ILE A 180
HIS A 222
LEU A 247
 None
 1.46A 1qkuC-3dmyA:
undetectable		 1qkuC-3dmyA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 8 GLY A 227
GLY A 172
MET A 171
LEU A 226
SER A 178
 None
 1.16A 1qzzA-3dmyA:
2.5		 1qzzA-3dmyA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 12 LEU A 508
ILE A 196
GLY A 197
VAL A 198
LEU A 209
 None
 0.93A 1vptA-3dmyA:
undetectable		 1vptA-3dmyA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 12 GLY A 475
ALA A 474
ILE A 468
PRO A 427
VAL A 432
 None
 0.81A 2b7zA-3dmyA:
undetectable		 2b7zA-3dmyA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 12 THR A 319
GLU A 484
LEU A 487
LEU A 314
ILE A 213
 None
 1.05A 2jfaA-3dmyA:
undetectable		 2jfaA-3dmyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 6 ASP A 230
SER A 239
VAL A 170
GLY A 225
GLY A 227
 None
 1.49A 2otvA-3dmyA:
undetectable		 2otvA-3dmyA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 12 THR A 319
GLU A 484
LEU A 487
LEU A 314
ILE A 213
 None
 1.02A 2qxsA-3dmyA:
undetectable		 2qxsA-3dmyA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 12 THR A 319
GLU A 484
LEU A 487
LEU A 314
ILE A 213
 None
 1.03A 2qxsB-3dmyA:
undetectable		 2qxsB-3dmyA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 9 PHE A 147
LEU A 209
ILE A 220
GLU A 524
GLY A 176
 None
 1.04A 2v0mB-3dmyA:
undetectable		 2v0mB-3dmyA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 12 LEU A 153
PRO A 173
ILE A 199
VAL A 259
LEU A 231
 None
 1.18A 2zzmA-3dmyA:
undetectable		 2zzmA-3dmyA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 12 THR A 424
ASP A 393
ILE A 419
GLY A 420
LEU A 431
 None
 1.15A 3eeyA-3dmyA:
undetectable		 3eeyA-3dmyA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 12 THR A 424
ASP A 393
ILE A 419
GLY A 420
LEU A 431
 None
 1.17A 3eeyB-3dmyA:
3.7		 3eeyB-3dmyA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 12 THR A 424
ASP A 393
ILE A 419
GLY A 420
LEU A 431
 None
 1.16A 3eeyC-3dmyA:
2.6		 3eeyC-3dmyA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 12 THR A 424
ASP A 393
ILE A 419
GLY A 420
LEU A 431
 None
 1.10A 3eeyE-3dmyA:
3.7		 3eeyE-3dmyA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 12 THR A 424
ASP A 393
ILE A 419
GLY A 420
LEU A 431
 None
 1.13A 3eeyF-3dmyA:
undetectable		 3eeyF-3dmyA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 12 THR A 424
ASP A 393
ILE A 419
GLY A 420
LEU A 431
 None
 1.10A 3eeyI-3dmyA:
undetectable		 3eeyI-3dmyA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 12 THR A 424
ASP A 393
ILE A 419
GLY A 420
LEU A 431
 None
 1.10A 3eeyJ-3dmyA:
undetectable		 3eeyJ-3dmyA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 12 GLY A 475
ALA A 474
ILE A 468
PRO A 427
VAL A 432
 None
 0.77A 3el4A-3dmyA:
undetectable		 3el4A-3dmyA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 12 GLY A 475
ALA A 474
ILE A 468
PRO A 427
VAL A 432
 None
 0.79A 3el5B-3dmyA:
undetectable		 3el5B-3dmyA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		4 / 8 GLY A 405
ASP A 403
VAL A 410
GLN A 409
 None
 0.80A 3fi0B-3dmyA:
undetectable		 3fi0B-3dmyA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		4 / 8 GLY A 405
ASP A 403
VAL A 410
GLN A 409
 None
 0.78A 3fi0I-3dmyA:
undetectable		 3fi0I-3dmyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 9 GLY A 475
ALA A 474
ILE A 468
LEU A 431
VAL A 432
 None
 0.85A 3u7sB-3dmyA:
undetectable		 3u7sB-3dmyA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		3 / 3 GLU A 218
GLY A 219
SER A 316
 None
 0.70A 4b53B-3dmyA:
undetectable		 4b53B-3dmyA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		4 / 8 GLY A 172
ASP A 174
GLY A 227
VAL A 235
 None
 0.83A 4c5nC-3dmyA:
undetectable		 4c5nC-3dmyA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 10 ALA A 111
ILE A 514
ILE A 123
LEU A 133
ILE A 516
 None
 1.17A 4dtaA-3dmyA:
undetectable		 4dtaA-3dmyA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 12 LEU A 120
ILE A 224
ALA A 528
GLU A 524
GLY A 182
 None
 1.14A 4hfpD-3dmyA:
undetectable		 4hfpD-3dmyA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		4 / 4 VAL A 151
ILE A 123
ASN A 135
VAL A 170
 None
 1.27A 5ajqA-3dmyA:
undetectable		 5ajqA-3dmyA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		3 / 3 VAL A 198
GLN A 207
CYH A 210
 None
 0.80A 5icxA-3dmyA:
undetectable
5icxE-3dmyA:
undetectable		 5icxA-3dmyA:
18.91
5icxE-3dmyA:
3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		3 / 3 VAL A 511
SER A 178
MET A 191
 None
 0.86A 5ikqA-3dmyA:
undetectable		 5ikqA-3dmyA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 12 ALA A 312
LEU A 315
ALA A 223
GLY A 197
PRO A 281
 None
 1.25A 5jglA-3dmyA:
3.3		 5jglA-3dmyA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		4 / 7 GLY A 127
ALA A 126
GLY A 517
ILE A 516
 None
 0.64A 5kqyB-3dmyA:
undetectable		 5kqyB-3dmyA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3dmy PROTEIN FDRA
(Escherichia
coli) 		5 / 12 ASP A 416
ALA A 344
GLY A 379
GLY A 339
ARG A 397
 None
 1.07A 6clxA-3dmyA:
2.9		 6clxA-3dmyA:
24.10