SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dnp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3dnp STRESS RESPONSE
PROTEIN YHAX
(Bacillus
subtilis) 		4 / 8 LEU A 211
LEU A 204
GLY A 203
ILE A  71
 None
 0.90A 1n13A-3dnpA:
undetectable
1n13F-3dnpA:
undetectable		 1n13A-3dnpA:
17.91
1n13F-3dnpA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3dnp STRESS RESPONSE
PROTEIN YHAX
(Bacillus
subtilis) 		4 / 8 ILE A  71
LEU A 211
LEU A 204
GLY A 203
 None
 0.89A 2qqcH-3dnpA:
undetectable
2qqcK-3dnpA:
undetectable		 2qqcH-3dnpA:
17.88
2qqcK-3dnpA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3dnp STRESS RESPONSE
PROTEIN YHAX
(Bacillus
subtilis) 		4 / 8 ILE A  71
LEU A 211
LEU A 204
GLY A 203
 None
 0.89A 2qqdB-3dnpA:
undetectable
2qqdC-3dnpA:
undetectable		 2qqdB-3dnpA:
17.88
2qqdC-3dnpA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3dnp STRESS RESPONSE
PROTEIN YHAX
(Bacillus
subtilis) 		5 / 12 MET A 230
ILE A  64
VAL A 207
LEU A 211
LEU A 204
 None
 1.48A 4m11A-3dnpA:
undetectable		 4m11A-3dnpA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3dnp STRESS RESPONSE
PROTEIN YHAX
(Bacillus
subtilis) 		5 / 12 MET A 230
ILE A  64
VAL A 207
LEU A 211
LEU A 204
 None
 1.48A 4m11D-3dnpA:
undetectable		 4m11D-3dnpA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 3dnp STRESS RESPONSE
PROTEIN YHAX
(Bacillus
subtilis) 		5 / 9 ASP A 259
ALA A 264
GLY A  12
SER A 257
GLY A 262
 None
 1.40A 4mmeA-3dnpA:
undetectable		 4mmeA-3dnpA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3dnp STRESS RESPONSE
PROTEIN YHAX
(Bacillus
subtilis) 		5 / 7 ASN A 114
LEU A 144
LEU A 148
GLU A 159
LEU A 105
 None
 1.47A 4wg0L-3dnpA:
undetectable
4wg0M-3dnpA:
undetectable		 4wg0L-3dnpA:
3.83
4wg0M-3dnpA:
3.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 3dnp STRESS RESPONSE
PROTEIN YHAX
(Bacillus
subtilis) 		4 / 5 ALA A 251
ALA A 239
ILE A 231
LEU A 228
 None
 0.76A 5jncD-3dnpA:
undetectable		 5jncD-3dnpA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3dnp STRESS RESPONSE
PROTEIN YHAX
(Bacillus
subtilis) 		4 / 5 LEU A  41
ALA A   7
LEU A   6
LEU A 204
 None
 0.86A 5vkqA-3dnpA:
undetectable
5vkqD-3dnpA:
undetectable		 5vkqA-3dnpA:
11.00
5vkqD-3dnpA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3dnp STRESS RESPONSE
PROTEIN YHAX
(Bacillus
subtilis) 		4 / 5 LEU A 204
LEU A  41
ALA A   7
LEU A   6
 None
 0.82A 5vkqB-3dnpA:
undetectable
5vkqC-3dnpA:
undetectable		 5vkqB-3dnpA:
11.00
5vkqC-3dnpA:
11.00