SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3do5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 3do5 HOMOSERINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 10 GLU A 192
ALA A 193
LEU A 196
GLU A 181
GLU A 180
 None
 1.03A 1a29A-3do5A:
undetectable		 1a29A-3do5A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 3do5 HOMOSERINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 PHE A 122
ILE A 219
THR A 112
THR A 141
VAL A 142
 None
 1.09A 1cbsA-3do5A:
undetectable		 1cbsA-3do5A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 3do5 HOMOSERINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		4 / 7 PHE A   9
ALA A  55
LEU A  52
VAL A  36
 None
 0.86A 1hk2A-3do5A:
undetectable		 1hk2A-3do5A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3do5 HOMOSERINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 10 ALA A 248
GLN A 246
PHE A 245
ALA A 249
ILE A 237
 None
 1.18A 2aclC-3do5A:
undetectable		 2aclC-3do5A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3do5 HOMOSERINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 10 GLY A 306
GLU A 309
GLY A 144
ALA A 313
ALA A 145
 None
 1.04A 2ej3B-3do5A:
undetectable		 2ej3B-3do5A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3do5 HOMOSERINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 8 GLY A 306
GLU A 309
GLY A 144
ALA A 313
ALA A 145
 None
 1.07A 2ej3C-3do5A:
undetectable		 2ej3C-3do5A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 3do5 HOMOSERINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 PHE A 122
ILE A 219
THR A 112
THR A 141
VAL A 142
 None
 1.05A 2fr3A-3do5A:
undetectable		 2fr3A-3do5A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 3do5 HOMOSERINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 PHE A 122
ILE A 219
THR A 112
THR A 141
VAL A 142
 None
 1.08A 2g78A-3do5A:
undetectable		 2g78A-3do5A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3do5 HOMOSERINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		3 / 3 LEU A 118
PRO A 117
LEU A 125
 None
 0.60A 2po5B-3do5A:
3.0		 2po5B-3do5A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3do5 HOMOSERINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		4 / 7 THR A 171
TYR A 198
GLN A 194
ASP A 206
 None
 1.20A 2xytI-3do5A:
undetectable		 2xytI-3do5A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3do5 HOMOSERINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 THR A 254
VAL A 273
PHE A 245
ILE A 237
THR A 235
 None
 1.30A 3elzC-3do5A:
undetectable		 3elzC-3do5A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 3do5 HOMOSERINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		4 / 8 VAL A 164
ILE A 219
SER A 262
ALA A 227
 None
None
None
PEG  A 329 ( 4.5A)
 1.01A 4eyzB-3do5A:
undetectable		 4eyzB-3do5A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 3do5 HOMOSERINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		4 / 7 LEU A  19
ILE A   2
ILE A   4
VAL A  82
 None
 0.75A 4ojbA-3do5A:
undetectable		 4ojbA-3do5A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3do5 HOMOSERINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 9 ILE A  72
VAL A  75
GLY A  96
THR A 112
VAL A   7
 None
 1.21A 4r20B-3do5A:
undetectable		 4r20B-3do5A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3do5 HOMOSERINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 9 ALA A  78
ALA A  38
SER A  47
ALA A  40
SER A  45
 None
 1.22A 4twdA-3do5A:
undetectable
4twdB-3do5A:
undetectable
4twdC-3do5A:
undetectable
4twdD-3do5A:
undetectable
4twdE-3do5A:
undetectable		 4twdA-3do5A:
22.69
4twdB-3do5A:
22.69
4twdC-3do5A:
22.69
4twdD-3do5A:
22.69
4twdE-3do5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3do5 HOMOSERINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 9 LEU A 315
ILE A  27
ILE A   6
GLU A  85
GLU A  18
 None
 1.39A 5igzA-3do5A:
undetectable		 5igzA-3do5A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 3do5 HOMOSERINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 PHE A  34
ILE A   4
ALA A  86
SER A 113
VAL A  16
 None
 1.41A 5mlmA-3do5A:
8.3		 5mlmA-3do5A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 3do5 HOMOSERINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		4 / 8 GLU A  85
VAL A 110
GLY A 116
LEU A 118
 None
None
PO4  A 328 (-4.2A)
None
 0.98A 5sxqA-3do5A:
undetectable		 5sxqA-3do5A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 3do5 HOMOSERINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		4 / 8 GLU A  85
VAL A 110
GLY A 116
LEU A 118
 None
None
PO4  A 328 (-4.2A)
None
 0.96A 5sxqB-3do5A:
undetectable		 5sxqB-3do5A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 3do5 HOMOSERINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		4 / 8 GLU A  85
VAL A 110
GLY A 116
LEU A 118
 None
None
PO4  A 328 (-4.2A)
None
 0.97A 5sxtA-3do5A:
undetectable		 5sxtA-3do5A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 3do5 HOMOSERINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		4 / 8 GLU A  85
VAL A 110
GLY A 116
LEU A 118
 None
None
PO4  A 328 (-4.2A)
None
 0.97A 5sxtB-3do5A:
undetectable		 5sxtB-3do5A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 3do5 HOMOSERINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		4 / 8 GLU A  85
VAL A 110
GLY A 116
LEU A 118
 None
None
PO4  A 328 (-4.2A)
None
 0.96A 5syjB-3do5A:
undetectable		 5syjB-3do5A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 3do5 HOMOSERINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 10 VAL A 110
GLU A 121
MET A 126
LEU A 118
THR A 141
 None
 1.44A 6d9hR-3do5A:
undetectable		 6d9hR-3do5A:
17.45