SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3do6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		5 / 11 ALA A 124
THR A 154
ALA A 192
ALA A 195
LEU A 236
 None
 1.06A 1jinA-3do6A:
undetectable		 1jinA-3do6A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		5 / 12 ILE A  25
ALA A 195
SER A 269
GLY A 116
TYR A  21
 None
None
None
None
EDO  A 549 (-4.5A)
 1.09A 1kiaA-3do6A:
undetectable		 1kiaA-3do6A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		3 / 3 ASP A 292
PHE A 494
VAL A 472
 None
 0.78A 1kijB-3do6A:
undetectable		 1kijB-3do6A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		5 / 12 ILE A  25
ALA A 195
SER A 269
GLY A 116
TYR A  21
 None
None
None
None
EDO  A 549 (-4.5A)
 1.07A 1nbhB-3do6A:
undetectable		 1nbhB-3do6A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		4 / 6 ARG A 222
ALA A 503
ILE A 193
GLU A 189
 None
 1.10A 1oniB-3do6A:
undetectable
1oniC-3do6A:
undetectable		 1oniB-3do6A:
14.81
1oniC-3do6A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		4 / 7 ILE A 193
GLU A 189
ARG A 222
ALA A 503
 None
 1.16A 1oniD-3do6A:
undetectable
1oniE-3do6A:
undetectable		 1oniD-3do6A:
14.81
1oniE-3do6A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		4 / 7 ILE A 193
GLU A 189
ARG A 222
ALA A 503
 None
 1.10A 1oniG-3do6A:
undetectable
1oniI-3do6A:
undetectable		 1oniG-3do6A:
14.81
1oniI-3do6A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		4 / 5 LEU A  81
VAL A 352
LEU A 348
ARG A 390
 None
 1.11A 2oiqA-3do6A:
undetectable		 2oiqA-3do6A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		4 / 5 LEU A 105
ILE A  64
SER A 102
GLY A 100
 None
 0.95A 2otfA-3do6A:
undetectable		 2otfA-3do6A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		5 / 12 LEU A  13
LEU A 279
MET A 275
ILE A   4
SER A 280
 None
 1.33A 2pnjB-3do6A:
2.6		 2pnjB-3do6A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		3 / 3 PHE A 260
ASN A 262
PHE A 289
 None
 1.02A 2zbuD-3do6A:
undetectable		 2zbuD-3do6A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		5 / 12 LEU A  13
LEU A 279
MET A 275
ILE A   4
SER A 280
 None
 1.31A 3aqiB-3do6A:
1.5		 3aqiB-3do6A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		4 / 6 ILE A 271
THR A 267
PHE A 298
PHE A 308
 None
 1.13A 3elzB-3do6A:
undetectable		 3elzB-3do6A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		5 / 12 ILE A  25
THR A 115
ASN A 268
ILE A 255
PRO A 106
 None
 0.98A 3kpdC-3do6A:
undetectable		 3kpdC-3do6A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		3 / 3 SER A  69
GLY A 404
SER A 102
 None
 0.69A 3loqA-3do6A:
1.7		 3loqA-3do6A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		4 / 6 LEU A 348
ALA A 488
ARG A 349
LEU A 322
 None
 1.05A 3ravA-3do6A:
undetectable		 3ravA-3do6A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		5 / 12 ALA A 456
ILE A 434
GLU A 435
LEU A 511
VAL A 496
 EDO  A 544 ( 4.0A)
None
None
None
None
 0.97A 4azsA-3do6A:
undetectable		 4azsA-3do6A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		5 / 12 ALA A 456
ILE A 434
GLU A 435
LEU A 511
VAL A 496
 EDO  A 544 ( 4.0A)
None
None
None
None
 0.96A 4aztA-3do6A:
undetectable		 4aztA-3do6A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		5 / 12 ALA A 456
ILE A 434
LEU A 511
SER A 497
VAL A 496
 EDO  A 544 ( 4.0A)
None
None
None
None
 0.90A 4azvA-3do6A:
undetectable		 4azvA-3do6A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		4 / 4 ASN A  71
VAL A 284
THR A 247
ILE A  64
 None
 1.47A 4retA-3do6A:
undetectable		 4retA-3do6A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		4 / 4 ASN A  71
VAL A 284
THR A 247
ILE A  64
 None
 1.47A 4retC-3do6A:
undetectable		 4retC-3do6A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		4 / 7 ILE A  64
LYS A  59
GLY A  95
GLY A  98
 None
 0.83A 5a06A-3do6A:
undetectable		 5a06A-3do6A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		4 / 7 ILE A  64
LYS A  59
GLY A  95
GLY A  98
 None
 0.83A 5a06C-3do6A:
undetectable		 5a06C-3do6A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		4 / 7 ILE A  64
LYS A  59
GLY A  95
GLY A  98
 None
 0.81A 5a06E-3do6A:
undetectable		 5a06E-3do6A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		4 / 7 ILE A  64
LYS A  59
GLY A  95
GLY A  98
 None
 0.81A 5a06F-3do6A:
undetectable		 5a06F-3do6A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		5 / 12 ALA A 473
GLU A 296
ILE A 436
GLU A 431
ALA A 438
 None
 1.16A 5n5dB-3do6A:
undetectable		 5n5dB-3do6A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		5 / 12 MET A 191
SER A 197
GLU A 198
LEU A 203
ILE A 240
 None
 1.35A 5vlmB-3do6A:
undetectable		 5vlmB-3do6A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		4 / 5 ASN A 199
ASP A 202
SER A 197
ARG A 206
 None
 1.30A 5w4zA-3do6A:
undetectable		 5w4zA-3do6A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		5 / 10 LEU A 511
ILE A 434
LEU A 437
ASN A 262
LEU A 293
 None
 1.18A 5y7pB-3do6A:
undetectable		 5y7pB-3do6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		5 / 10 LEU A 511
ILE A 434
LEU A 437
ASN A 262
LEU A 293
 None
 1.19A 5y7pD-3do6A:
undetectable		 5y7pD-3do6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		5 / 10 LEU A 511
ILE A 434
LEU A 437
ASN A 262
LEU A 293
 None
 1.18A 5y7pH-3do6A:
undetectable		 5y7pH-3do6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_B_SAMB401_0
(O-METHYLTRANSFERASE)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		5 / 10 ARG A  82
ALA A 287
GLY A 290
ASP A 292
SER A 480
 None
 1.27A 6clxB-3do6A:
1.0		 6clxB-3do6A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 3do6 FORMATE--TETRAHYDROF
OLATE LIGASE
(Thermotoga
maritima) 		4 / 8 GLY A 520
LEU A  90
GLY A  91
LEU A 521
 None
 0.87A 6mdqA-3do6A:
undetectable		 6mdqA-3do6A:
9.58