SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3doa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3doa FIBRINOGEN BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 8 GLY A  85
VAL A  23
GLU A  83
SER A 105
 None
 0.87A 1pk7B-3doaA:
undetectable		 1pk7B-3doaA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3doa FIBRINOGEN BINDING
PROTEIN
(Staphylococcus
aureus) 		5 / 9 PHE A 198
VAL A 179
LEU A 221
MET A 229
LEU A 194
 None
 1.29A 1wrkA-3doaA:
3.0
1wrkB-3doaA:
2.9		 1wrkA-3doaA:
14.96
1wrkB-3doaA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_2
(VITAMIN D3 RECEPTOR)		 3doa FIBRINOGEN BINDING
PROTEIN
(Staphylococcus
aureus) 		5 / 9 LEU A  60
ILE A  26
ARG A  79
LEU A 128
VAL A  38
 None
 1.29A 3m7rA-3doaA:
undetectable		 3m7rA-3doaA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 3doa FIBRINOGEN BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 5 PHE A 251
ILE A 205
ASN A  54
PHE A 253
 None
 1.38A 3octA-3doaA:
undetectable		 3octA-3doaA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3doa FIBRINOGEN BINDING
PROTEIN
(Staphylococcus
aureus) 		3 / 3 PRO A 203
LEU A 204
HIS A 241
 None
 0.64A 4pevA-3doaA:
undetectable		 4pevA-3doaA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 3doa FIBRINOGEN BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 8 ILE A 121
MET A  36
LEU A  15
ILE A  90
 None
 0.96A 5ieoA-3doaA:
1.7		 5ieoA-3doaA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 3doa FIBRINOGEN BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 8 LEU A 273
LEU A   6
GLY A   5
ARG A  97
 None
 0.95A 6ce2A-3doaA:
undetectable		 6ce2A-3doaA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3doa FIBRINOGEN BINDING
PROTEIN
(Staphylococcus
aureus) 		5 / 12 ILE A 129
VAL A 131
ILE A  51
HIS A 143
VAL A 154
 None
 1.47A 6j21A-3doaA:
undetectable		 6j21A-3doaA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3doa FIBRINOGEN BINDING
PROTEIN
(Staphylococcus
aureus) 		5 / 12 TYR A 172
ILE A 205
TYR A 252
ILE A 254
ILE A  99
 None
 1.23A 6mkeA-3doaA:
undetectable
6mkeD-3doaA:
undetectable		 6mkeA-3doaA:
11.90
6mkeD-3doaA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3doa FIBRINOGEN BINDING
PROTEIN
(Staphylococcus
aureus) 		5 / 12 TYR A 172
ILE A 205
TYR A 252
ILE A 254
ILE A  99
 None
 1.26A 6mkeB-3doaA:
undetectable
6mkeC-3doaA:
undetectable		 6mkeB-3doaA:
11.90
6mkeC-3doaA:
11.90