SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dpi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 3dpi NAD+ SYNTHETASE
(Burkholderia
pseudomallei) 		5 / 10 ALA A 187
GLY A 185
LEU A  50
LEU A 190
PRO A 191
 None
 1.39A 1cmcA-3dpiA:
undetectable
1cmcB-3dpiA:
undetectable		 1cmcA-3dpiA:
17.11
1cmcB-3dpiA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_A_T44A428_1
(TRANSTHYRETIN
THR119MET VARIANT)		 3dpi NAD+ SYNTHETASE
(Burkholderia
pseudomallei) 		4 / 4 LYS A 146
LEU A 142
ALA A 118
LEU A 122
 None
 1.07A 1f86A-3dpiA:
0.0		 1f86A-3dpiA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 3dpi NAD+ SYNTHETASE
(Burkholderia
pseudomallei) 		4 / 4 LYS A 146
LEU A 142
ALA A 118
LEU A 122
 None
 0.80A 1f86B-3dpiA:
undetectable		 1f86B-3dpiA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3dpi NAD+ SYNTHETASE
(Burkholderia
pseudomallei) 		4 / 6 ASP A 139
LEU A 142
GLY A 143
ARG A 226
 None
 0.80A 1mt1G-3dpiA:
undetectable
1mt1J-3dpiA:
undetectable		 1mt1G-3dpiA:
10.56
1mt1J-3dpiA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3dpi NAD+ SYNTHETASE
(Burkholderia
pseudomallei) 		4 / 7 ARG A 226
ASP A 139
LEU A 142
GLY A 143
 None
 0.76A 1mt1H-3dpiA:
undetectable
1mt1K-3dpiA:
undetectable		 1mt1H-3dpiA:
17.50
1mt1K-3dpiA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3dpi NAD+ SYNTHETASE
(Burkholderia
pseudomallei) 		4 / 7 ARG A 226
ASP A 139
LEU A 142
GLY A 143
 None
 0.74A 1n13D-3dpiA:
undetectable
1n13E-3dpiA:
undetectable		 1n13D-3dpiA:
17.50
1n13E-3dpiA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3dpi NAD+ SYNTHETASE
(Burkholderia
pseudomallei) 		4 / 8 ASP A 139
LEU A 142
GLY A 143
ARG A 226
 None
 0.76A 1n13A-3dpiA:
undetectable
1n13F-3dpiA:
undetectable		 1n13A-3dpiA:
10.56
1n13F-3dpiA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3dpi NAD+ SYNTHETASE
(Burkholderia
pseudomallei) 		4 / 6 ARG A 226
ASP A 139
LEU A 142
GLY A 143
 None
 0.76A 1n13H-3dpiA:
undetectable
1n13K-3dpiA:
undetectable		 1n13H-3dpiA:
17.50
1n13K-3dpiA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3dpi NAD+ SYNTHETASE
(Burkholderia
pseudomallei) 		4 / 7 ASP A 139
LEU A 142
GLY A 143
ARG A 226
 None
 0.77A 1n13G-3dpiA:
undetectable
1n13J-3dpiA:
undetectable		 1n13G-3dpiA:
10.56
1n13J-3dpiA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 3dpi NAD+ SYNTHETASE
(Burkholderia
pseudomallei) 		4 / 6 LYS A 146
LEU A 142
ALA A 118
LEU A 122
 None
 0.94A 1tz8C-3dpiA:
undetectable
1tz8D-3dpiA:
undetectable		 1tz8C-3dpiA:
20.59
1tz8D-3dpiA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3dpi NAD+ SYNTHETASE
(Burkholderia
pseudomallei) 		5 / 10 TYR A  88
LEU A 122
ALA A 118
ILE A 145
ALA A 220
 None
 1.10A 1xp0A-3dpiA:
undetectable		 1xp0A-3dpiA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 3dpi NAD+ SYNTHETASE
(Burkholderia
pseudomallei) 		4 / 5 ILE A  33
LEU A  67
ALA A  29
PHE A 103
 None
 0.93A 2opxA-3dpiA:
undetectable		 2opxA-3dpiA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3dpi NAD+ SYNTHETASE
(Burkholderia
pseudomallei) 		5 / 12 ILE A  56
ILE A 166
THR A 168
LEU A  50
LEU A 203
 None
 1.17A 2qo5A-3dpiA:
undetectable		 2qo5A-3dpiA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3dpi NAD+ SYNTHETASE
(Burkholderia
pseudomallei) 		4 / 7 ARG A 226
ASP A 139
LEU A 142
GLY A 143
 None
 0.76A 2qqcD-3dpiA:
undetectable
2qqcE-3dpiA:
undetectable		 2qqcD-3dpiA:
18.57
2qqcE-3dpiA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3dpi NAD+ SYNTHETASE
(Burkholderia
pseudomallei) 		4 / 8 ARG A 226
ASP A 139
LEU A 142
GLY A 143
 None
 0.80A 2qqcH-3dpiA:
undetectable
2qqcK-3dpiA:
undetectable		 2qqcH-3dpiA:
18.57
2qqcK-3dpiA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3dpi NAD+ SYNTHETASE
(Burkholderia
pseudomallei) 		4 / 8 ARG A 226
ASP A 139
LEU A 142
GLY A 143
 None
 0.78A 2qqdB-3dpiA:
undetectable
2qqdC-3dpiA:
undetectable		 2qqdB-3dpiA:
18.21
2qqdC-3dpiA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 3dpi NAD+ SYNTHETASE
(Burkholderia
pseudomallei) 		4 / 7 ALA A  65
GLY A  62
VAL A 104
ARG A  80
 None
 0.81A 2uyqA-3dpiA:
undetectable		 2uyqA-3dpiA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3dpi NAD+ SYNTHETASE
(Burkholderia
pseudomallei) 		4 / 8 PHE A  81
LEU A  86
LEU A 101
ALA A 106
 None
 0.85A 2vcvP-3dpiA:
undetectable		 2vcvP-3dpiA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3dpi NAD+ SYNTHETASE
(Burkholderia
pseudomallei) 		5 / 11 THR A 217
VAL A 200
LEU A 192
TYR A 239
THR A 168
 None
 1.47A 3elzB-3dpiA:
undetectable		 3elzB-3dpiA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3dpi NAD+ SYNTHETASE
(Burkholderia
pseudomallei) 		5 / 12 ILE A  56
ASP A 221
PRO A 218
ALA A 220
ALA A  61
 None
 1.09A 3jb1A-3dpiA:
undetectable		 3jb1A-3dpiA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3dpi NAD+ SYNTHETASE
(Burkholderia
pseudomallei) 		3 / 3 TYR A 155
ASP A 184
ASP A 221
 None
 0.93A 3ou6B-3dpiA:
2.1		 3ou6B-3dpiA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 3dpi NAD+ SYNTHETASE
(Burkholderia
pseudomallei) 		5 / 9 ARG A  26
ALA A  29
ASP A  24
LEU A 203
LEU A 207
 None
 1.01A 5dqfA-3dpiA:
undetectable		 5dqfA-3dpiA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 3dpi NAD+ SYNTHETASE
(Burkholderia
pseudomallei) 		3 / 3 ILE A  56
MET A 176
ASP A 221
 None
 0.77A 5h2uA-3dpiA:
undetectable		 5h2uA-3dpiA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 3dpi NAD+ SYNTHETASE
(Burkholderia
pseudomallei) 		5 / 10 ARG A 199
VAL A 200
LEU A  50
GLY A 194
GLY A 167
 None
 1.23A 6eu9B-3dpiA:
undetectable		 6eu9B-3dpiA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3dpi NAD+ SYNTHETASE
(Burkholderia
pseudomallei) 		4 / 6 ILE A  13
ALA A   8
ARG A  10
ASP A 253
 None
 1.15A 6hu9m-3dpiA:
undetectable
6hu9q-3dpiA:
undetectable		 6hu9m-3dpiA:
19.85
6hu9q-3dpiA:
19.63