SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dpr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3dpr PROTEIN VP3
(Rhinovirus
A) 		4 / 7 VAL C 127
LEU C 209
ALA C 206
LEU C  72
 None
 0.82A 1pthA-3dprC:
undetectable		 1pthA-3dprC:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3dpr PROTEIN VP3
(Rhinovirus
A) 		4 / 7 VAL C 127
LEU C 209
ALA C 206
LEU C  72
 None
 0.82A 1pthB-3dprC:
undetectable		 1pthB-3dprC:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3dpr PROTEIN VP2
(Rhinovirus
A) 		3 / 3 GLY B  19
ASP B  20
ASN B  61
 None
 0.65A 1vq1A-3dprB:
undetectable		 1vq1A-3dprB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 3dpr PROTEIN VP3
(Rhinovirus
A) 		4 / 4 LEU C 209
SER C  69
TYR C  68
LEU C  52
 None
 0.87A 1xz1A-3dprC:
undetectable		 1xz1A-3dprC:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 3dpr PROTEIN VP3
(Rhinovirus
A) 		4 / 4 LEU C 209
SER C  69
TYR C  68
LEU C  52
 None
 0.86A 1xz3A-3dprC:
undetectable		 1xz3A-3dprC:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3dpr PROTEIN VP2
PROTEIN VP3
(Rhinovirus
A) 		4 / 5 LEU B 126
GLY C  38
PRO B 205
ALA B 204
 None
 0.97A 2aohA-3dprB:
undetectable		 2aohA-3dprB:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 3dpr PROTEIN VP3
(Rhinovirus
A) 		4 / 7 LEU C  94
PHE C 211
PHE C 115
ILE C  85
 None
 0.97A 2opxA-3dprC:
undetectable		 2opxA-3dprC:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3dpr PROTEIN VP3
(Rhinovirus
A) 		4 / 8 ASP C  50
SER C 213
SER C 116
CYH C 210
 None
 1.20A 2xz5C-3dprC:
undetectable
2xz5D-3dprC:
undetectable		 2xz5C-3dprC:
22.98
2xz5D-3dprC:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 3dpr PROTEIN VP2
(Rhinovirus
A) 		4 / 6 ARG B 216
PRO B 248
GLY B  93
MET B  89
 None
 1.37A 3aqiA-3dprB:
undetectable		 3aqiA-3dprB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB4_0
(FERROCHELATASE)		 3dpr PROTEIN VP2
(Rhinovirus
A) 		4 / 6 ARG B 216
PRO B 248
GLY B  93
MET B  89
 None
 1.26A 3aqiB-3dprB:
undetectable		 3aqiB-3dprB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3dpr PROTEIN VP2
(Rhinovirus
A) 		4 / 5 THR B  70
THR B 233
HIS B 118
LEU B 194
 None
 1.37A 3ce6A-3dprB:
undetectable		 3ce6A-3dprB:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3dpr PROTEIN VP2
(Rhinovirus
A) 		4 / 5 THR B  70
THR B 233
HIS B 118
LEU B 194
 None
 1.37A 3ce6C-3dprB:
undetectable		 3ce6C-3dprB:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 3dpr PROTEIN VP3
(Rhinovirus
A) 		4 / 6 LEU C 209
SER C  69
TYR C  68
LEU C  52
 None
 0.85A 3f33A-3dprC:
undetectable		 3f33A-3dprC:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3dpr PROTEIN VP2
(Rhinovirus
A) 		5 / 12 GLY B  77
HIS B 130
LEU B 223
VAL B 110
ILE B 242
 None
 1.08A 3g9eA-3dprB:
undetectable		 3g9eA-3dprB:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 3dpr PROTEIN VP3
(Rhinovirus
A) 		4 / 6 LEU C 209
SER C  69
TYR C  68
LEU C  52
 None
 0.82A 3ravA-3dprC:
undetectable		 3ravA-3dprC:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 3dpr PROTEIN VP3
(Rhinovirus
A) 		4 / 6 LEU C 209
SER C  69
TYR C  68
LEU C  52
 None
 0.80A 3rd0A-3dprC:
undetectable		 3rd0A-3dprC:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dpr PROTEIN VP3
(Rhinovirus
A) 		5 / 11 ALA C 132
PHE C 117
SER C 164
PHE C 211
VAL C 167
 None
 1.43A 4eilE-3dprC:
undetectable		 4eilE-3dprC:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3dpr LDL-RECEPTOR CLASS A
3
(Homo
sapiens) 		4 / 7 ASP E  35
ASN E  28
GLU E  27
ASP E  31
 CA  E  50 (-3.5A)
None
None
None
 1.15A 4fewB-3dprE:
undetectable		 4fewB-3dprE:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 3dpr PROTEIN VP2
(Rhinovirus
A) 		3 / 3 TYR B 144
ARG B 216
SER B 217
 None
 1.08A 4lf7I-3dprB:
undetectable
4lf7J-3dprB:
undetectable		 4lf7I-3dprB:
17.60
4lf7J-3dprB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 3dpr PROTEIN VP2
(Rhinovirus
A) 		3 / 3 TYR B 144
ARG B 216
SER B 217
 None
 1.08A 4lf8I-3dprB:
undetectable
4lf8J-3dprB:
undetectable		 4lf8I-3dprB:
17.60
4lf8J-3dprB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3dpr PROTEIN VP3
PROTEIN VP4
(Rhinovirus
A) 		4 / 8 PHE C  19
TYR D  31
PHE D  27
ILE C   6
 None
 0.95A 4qoiA-3dprC:
undetectable
4qoiB-3dprC:
undetectable		 4qoiA-3dprC:
22.39
4qoiB-3dprC:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 3dpr PROTEIN VP2
(Rhinovirus
A) 		4 / 4 VAL B 110
ALA B 200
ASN B 197
GLN B 190
 None
 1.38A 4zgfA-3dprB:
undetectable		 4zgfA-3dprB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3dpr PROTEIN VP2
(Rhinovirus
A) 		4 / 6 VAL B 110
ALA B 200
GLN B 190
VAL B 124
 None
 0.98A 5i8fA-3dprB:
undetectable		 5i8fA-3dprB:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3dpr PROTEIN VP2
PROTEIN VP3
(Rhinovirus
A;
Rhinovirus
A) 		4 / 5 ARG C 207
CYH C 120
GLN B 119
ILE B 228
 None
 1.43A 5ki6A-3dprC:
undetectable		 5ki6A-3dprC:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 3dpr PROTEIN VP2
PROTEIN VP3
(Rhinovirus
A;
Rhinovirus
A) 		5 / 12 LEU C  98
GLY C 100
ASN B 183
TYR C  68
LEU C  52
 None
 1.39A 5kklB-3dprC:
undetectable		 5kklB-3dprC:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 3dpr PROTEIN VP2
PROTEIN VP3
(Rhinovirus
A;
Rhinovirus
A) 		5 / 12 LEU C  98
GLY C 100
ASN B 183
TYR C  68
MET C  67
 None
 1.37A 5kklB-3dprC:
undetectable		 5kklB-3dprC:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 3dpr PROTEIN VP3
(Rhinovirus
A) 		4 / 8 PRO C 199
ALA C 206
THR C 202
TRP C 155
 None
 1.01A 5x2tI-3dprC:
undetectable
5x2tJ-3dprC:
undetectable
5x2tK-3dprC:
undetectable
5x2tL-3dprC:
undetectable		 5x2tI-3dprC:
21.11
5x2tJ-3dprC:
19.57
5x2tK-3dprC:
21.11
5x2tL-3dprC:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3dpr PROTEIN VP2
PROTEIN VP3
(Rhinovirus
A) 		3 / 3 LEU B 180
THR C 226
ASN C 227
 None
 0.70A 6baaE-3dprB:
undetectable		 6baaE-3dprB:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3dpr PROTEIN VP2
PROTEIN VP3
(Rhinovirus
A) 		3 / 3 LEU B 180
THR C 226
ASN C 227
 None
 0.70A 6baaF-3dprB:
undetectable		 6baaF-3dprB:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3dpr PROTEIN VP2
PROTEIN VP3
(Rhinovirus
A) 		3 / 3 LEU B 180
THR C 226
ASN C 227
 None
 0.71A 6baaG-3dprB:
undetectable		 6baaG-3dprB:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3dpr PROTEIN VP2
PROTEIN VP3
(Rhinovirus
A) 		3 / 3 LEU B 180
THR C 226
ASN C 227
 None
 0.71A 6baaH-3dprB:
undetectable		 6baaH-3dprB:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 3dpr PROTEIN VP3
(Rhinovirus
A) 		4 / 6 SER C 171
SER C 185
SER C 183
ALA C 172
 None
 1.04A 6bocA-3dprC:
undetectable
6bocB-3dprC:
undetectable
6bocC-3dprC:
undetectable
6bocD-3dprC:
undetectable		 6bocA-3dprC:
9.09
6bocB-3dprC:
9.09
6bocC-3dprC:
9.09
6bocD-3dprC:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 3dpr PROTEIN VP3
(Rhinovirus
A) 		4 / 6 SER C 185
SER C 183
ALA C 172
SER C 171
 None
 1.04A 6bocA-3dprC:
undetectable
6bocB-3dprC:
undetectable
6bocC-3dprC:
undetectable
6bocD-3dprC:
undetectable		 6bocA-3dprC:
9.09
6bocB-3dprC:
9.09
6bocC-3dprC:
9.09
6bocD-3dprC:
9.09