SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dpt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 3dpt RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		5 / 12 VAL A 845
MET A 831
LEU A 833
MET A 817
GLU A 875
 None
 1.37A 1a27A-3dptA:
undetectable		 1a27A-3dptA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3dpt RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		4 / 6 ILE A 879
LEU A 813
TYR A 802
MET A 800
 None
 1.19A 3wg7A-3dptA:
undetectable
3wg7J-3dptA:
undetectable		 3wg7A-3dptA:
20.27
3wg7J-3dptA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 3dpt RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		4 / 5 VAL A 695
LEU A 673
LEU A 676
ILE A 657
 None
 0.96A 4a9jA-3dptA:
undetectable		 4a9jA-3dptA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 3dpt RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		4 / 8 TYR A 904
ASP A 934
VAL A 929
LEU A 908
 None
 1.10A 4f8hC-3dptA:
undetectable
4f8hD-3dptA:
undetectable		 4f8hC-3dptA:
20.96
4f8hD-3dptA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 3dpt RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		3 / 3 ASP A 758
ARG A 754
ASP A 768
 None
 0.88A 4fp9D-3dptA:
undetectable		 4fp9D-3dptA:
19.58