SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dpu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		3 / 3 GLU A 890
TYR A 904
PHE A 798
 None
 0.86A 1eqbB-3dpuA:
undetectable		 1eqbB-3dpuA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		3 / 3 GLU A 890
TYR A 904
PHE A 798
 None
 0.87A 1eqbA-3dpuA:
undetectable		 1eqbA-3dpuA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		3 / 3 GLU A 890
TYR A 904
PHE A 798
 None
 0.87A 1eqbD-3dpuA:
undetectable		 1eqbD-3dpuA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		3 / 3 GLU A 890
TYR A 904
PHE A 798
 None
 0.88A 1eqbC-3dpuA:
undetectable		 1eqbC-3dpuA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		5 / 10 ALA A 629
LEU A 447
PRO A 627
ALA A 440
GLY A 444
 None
 1.31A 1mjqG-3dpuA:
undetectable
1mjqH-3dpuA:
undetectable		 1mjqG-3dpuA:
12.82
1mjqH-3dpuA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		4 / 7 TRP A 551
TYR A 804
GLU A 520
GLY A 518
 None
 1.14A 2ha4B-3dpuA:
undetectable		 2ha4B-3dpuA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		4 / 5 LEU A 613
ASP A 503
LEU A 468
HIS A 596
 None
 1.27A 2qxsA-3dpuA:
undetectable		 2qxsA-3dpuA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		4 / 5 LEU A 613
ASP A 503
LEU A 468
HIS A 596
 None
 1.27A 2qxsB-3dpuA:
undetectable		 2qxsB-3dpuA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		4 / 7 ILE A 681
GLY A 680
PHE A 529
HIS A 512
 None
 0.81A 2y7wC-3dpuA:
undetectable		 2y7wC-3dpuA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		5 / 10 GLY A 461
ILE A 555
PHE A 529
GLY A 517
PHE A 516
 None
 1.29A 3ko0R-3dpuA:
undetectable
3ko0T-3dpuA:
undetectable		 3ko0R-3dpuA:
11.99
3ko0T-3dpuA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		4 / 6 ILE A 565
VAL A 567
LEU A 539
LEU A 457
 None
 0.66A 3kp6A-3dpuA:
undetectable
3kp6B-3dpuA:
4.8		 3kp6A-3dpuA:
16.21
3kp6B-3dpuA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		5 / 9 ILE A 555
LEU A 538
LYS A 486
MET A 462
GLY A 461
 None
 1.34A 3sj4X-3dpuA:
undetectable		 3sj4X-3dpuA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		4 / 5 VAL A 695
LEU A 673
LEU A 676
ILE A 657
 None
 0.97A 4a9jA-3dpuA:
undetectable		 4a9jA-3dpuA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		4 / 8 TYR A 904
ASP A 934
VAL A 929
LEU A 908
 None
 1.06A 4f8hA-3dpuA:
undetectable
4f8hB-3dpuA:
undetectable		 4f8hA-3dpuA:
21.00
4f8hB-3dpuA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		4 / 8 TYR A 904
ASP A 934
VAL A 929
LEU A 908
 None
 1.06A 4f8hB-3dpuA:
undetectable
4f8hC-3dpuA:
undetectable		 4f8hB-3dpuA:
21.00
4f8hC-3dpuA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		4 / 8 TYR A 904
ASP A 934
VAL A 929
LEU A 908
 None
 1.06A 4f8hC-3dpuA:
undetectable
4f8hD-3dpuA:
undetectable		 4f8hC-3dpuA:
21.00
4f8hD-3dpuA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		4 / 8 TYR A 904
ASP A 934
VAL A 929
LEU A 908
 None
 1.05A 4f8hD-3dpuA:
undetectable
4f8hE-3dpuA:
undetectable		 4f8hD-3dpuA:
21.00
4f8hE-3dpuA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		4 / 8 VAL A 929
LEU A 908
TYR A 904
ASP A 934
 None
 1.05A 4f8hA-3dpuA:
undetectable
4f8hE-3dpuA:
undetectable		 4f8hA-3dpuA:
21.00
4f8hE-3dpuA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		3 / 3 SER A 852
ALA A 847
VAL A 846
 None
 0.63A 4o2bA-3dpuA:
3.3		 4o2bA-3dpuA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		3 / 3 SER A 852
ALA A 847
VAL A 846
 None
 0.59A 4o2bC-3dpuA:
undetectable		 4o2bC-3dpuA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		4 / 5 GLU A 668
THR A 664
GLU A 655
LEU A 639
 None
 1.26A 5hm8A-3dpuA:
undetectable		 5hm8A-3dpuA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		4 / 5 GLU A 668
THR A 664
GLU A 655
LEU A 639
 None
 1.25A 5hm8B-3dpuA:
undetectable		 5hm8B-3dpuA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		4 / 5 GLU A 668
THR A 664
GLU A 655
LEU A 639
 None
 1.25A 5hm8C-3dpuA:
undetectable		 5hm8C-3dpuA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		4 / 5 GLU A 668
THR A 664
GLU A 655
LEU A 639
 None
 1.26A 5hm8D-3dpuA:
undetectable		 5hm8D-3dpuA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		4 / 5 GLU A 668
THR A 664
GLU A 655
LEU A 639
 None
 1.26A 5hm8E-3dpuA:
undetectable		 5hm8E-3dpuA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		4 / 5 GLU A 668
THR A 664
GLU A 655
LEU A 639
 None
 1.25A 5hm8F-3dpuA:
undetectable		 5hm8F-3dpuA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		4 / 5 GLU A 668
THR A 664
GLU A 655
LEU A 639
 None
 1.25A 5hm8H-3dpuA:
2.4		 5hm8H-3dpuA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		3 / 3 SER A 852
ALA A 847
VAL A 846
 None
 0.52A 5xiwC-3dpuA:
undetectable		 5xiwC-3dpuA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		3 / 3 GLN A 762
ILE A 703
HIS A 699
 None
 0.67A 5z12B-3dpuA:
undetectable		 5z12B-3dpuA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 3dpu RAB FAMILY PROTEIN
(Chlorobaculum
tepidum) 		5 / 11 ILE A 709
LEU A 780
PRO A 811
ILE A 815
MET A 814
 None
 1.35A 6fgcA-3dpuA:
1.9		 6fgcA-3dpuA:
9.55