SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dqz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		4 / 8 GLU A  38
LEU A 173
ALA A 170
LEU A 169
 None
 0.92A 1hwiD-3dqzA:
undetectable		 1hwiD-3dqzA:
18.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y7I_B_SALB503_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 10 ALA A  13
PHE A 107
TYR A 122
PHE A 153
HIS A 236
 None
 0.72A 1y7iB-3dqzA:
41.7		 1y7iB-3dqzA:
50.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 10 LEU A   9
VAL A  10
LEU A 104
ILE A  87
THR A  65
 None
 1.14A 3jw3A-3dqzA:
undetectable		 3jw3A-3dqzA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		4 / 5 ALA A  40
GLU A  57
ALA A  51
MET A 144
 None
 1.05A 3r9tC-3dqzA:
2.4		 3r9tC-3dqzA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 11 SER A 249
VAL A 102
VAL A 201
HIS A   5
ILE A  76
 None
 1.24A 3rf4A-3dqzA:
undetectable
3rf4C-3dqzA:
undetectable		 3rf4A-3dqzA:
17.97
3rf4C-3dqzA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 11 HIS A   5
ILE A  76
SER A 249
VAL A 102
VAL A 201
 None
 1.24A 3rf4A-3dqzA:
undetectable
3rf4B-3dqzA:
undetectable		 3rf4A-3dqzA:
17.97
3rf4B-3dqzA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 11 HIS A   5
ILE A  76
SER A 249
VAL A 102
VAL A 201
 None
 1.22A 3rf4B-3dqzA:
undetectable
3rf4C-3dqzA:
undetectable		 3rf4B-3dqzA:
17.97
3rf4C-3dqzA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		4 / 5 TYR A 167
ILE A 231
LEU A 246
LYS A 242
 None
 1.30A 3sueC-3dqzA:
undetectable		 3sueC-3dqzA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		3 / 3 LEU A 146
HIS A 137
MET A 144
 None
 0.93A 3thrD-3dqzA:
undetectable		 3thrD-3dqzA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		3 / 3 LEU A 158
HIS A 236
MET A 237
 None
 0.87A 3thrD-3dqzA:
undetectable		 3thrD-3dqzA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 11 LEU A 108
GLY A  84
ILE A 216
PHE A 223
GLY A  79
 None
 1.15A 3zosA-3dqzA:
undetectable
3zosB-3dqzA:
undetectable		 3zosA-3dqzA:
20.36
3zosB-3dqzA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 10 VAL A  78
LEU A 104
VAL A 102
LEU A 246
VAL A 203
 None
 1.01A 4e3hA-3dqzA:
undetectable		 4e3hA-3dqzA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		4 / 4 GLY A  83
LEU A  66
PHE A  94
ILE A  63
 None
 0.98A 4xv2A-3dqzA:
undetectable		 4xv2A-3dqzA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 10 MET A 237
LEU A 246
LEU A   9
GLY A  16
HIS A  15
 None
 1.18A 5dx3A-3dqzA:
undetectable		 5dx3A-3dqzA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 12 ILE A 253
ALA A 254
TYR A 257
GLY A  79
VAL A 203
 None
 1.04A 5i71A-3dqzA:
undetectable		 5i71A-3dqzA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 12 ILE A 253
ALA A 254
TYR A 257
GLY A  79
VAL A 203
 None
 1.04A 5i75A-3dqzA:
undetectable		 5i75A-3dqzA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		3 / 3 HIS A 117
ASP A 110
HIS A 113
 None
 0.64A 5n1tW-3dqzA:
undetectable		 5n1tW-3dqzA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		4 / 7 PHE A 107
ALA A  88
GLY A  84
GLY A  79
 None
 0.49A 5ybbB-3dqzA:
undetectable		 5ybbB-3dqzA:
19.65