SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dr2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		3 / 3 ALA A  10
VAL A  78
TRP A  72
 None
 0.90A 1bdwA-3dr2A:
undetectable
1bdwB-3dr2A:
undetectable		 1bdwA-3dr2A:
4.41
1bdwB-3dr2A:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		5 / 12 ARG A  22
GLY A 271
LEU A 269
PRO A 237
VAL A 236
 None
 1.04A 1gseA-3dr2A:
undetectable		 1gseA-3dr2A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		5 / 12 ARG A  22
GLY A 271
LEU A 269
PRO A 237
VAL A 236
 None
 0.95A 1gseB-3dr2A:
undetectable		 1gseB-3dr2A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		4 / 6 TRP A 222
ARG A 173
GLY A 142
ASP A 141
 None
 1.44A 1kf6M-3dr2A:
undetectable
1kf6N-3dr2A:
undetectable		 1kf6M-3dr2A:
18.89
1kf6N-3dr2A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		6 / 12 SER A 255
GLY A  49
GLY A 295
ALA A 279
LEU A  64
LEU A 136
 None
 1.08A 2nyuA-3dr2A:
undetectable		 2nyuA-3dr2A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		5 / 12 SER A 255
GLY A  49
GLY A 295
LEU A  64
LEU A 136
 None
 0.88A 2nyuB-3dr2A:
undetectable		 2nyuB-3dr2A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		5 / 12 PHE A 284
ALA A 234
ALA A 219
THR A 201
GLY A 250
 None
 1.07A 2ve3A-3dr2A:
undetectable		 2ve3A-3dr2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		5 / 12 PHE A 284
ALA A 234
ALA A 219
THR A 201
GLY A 250
 None
 1.07A 2ve3B-3dr2A:
undetectable		 2ve3B-3dr2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		4 / 6 VAL A 236
LEU A 269
CYH A 261
SER A 256
 None
 1.16A 3b6rB-3dr2A:
undetectable		 3b6rB-3dr2A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		3 / 3 CYH A 261
PRO A 274
ASP A 238
 None
 0.99A 3hlwB-3dr2A:
undetectable		 3hlwB-3dr2A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		4 / 4 PRO A 208
THR A 207
GLY A 257
THR A 258
 None
 1.17A 3ib1A-3dr2A:
undetectable		 3ib1A-3dr2A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		4 / 8 GLU A  48
HIS A 104
ASN A 134
LYS A 155
 CA  A 707 (-3.1A)
None
CA  A 707 (-3.0A)
None
 1.29A 3kp6A-3dr2A:
undetectable
3kp6B-3dr2A:
undetectable		 3kp6A-3dr2A:
16.77
3kp6B-3dr2A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		4 / 6 ILE A 109
ALA A 108
ALA A  86
THR A  88
 None
 0.98A 3mdrB-3dr2A:
undetectable		 3mdrB-3dr2A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		5 / 11 LEU A 130
THR A  88
ASN A  89
GLY A  90
ASP A 135
 None
None
CA  A 707 ( 4.3A)
None
CA  A 705 ( 4.8A)
 1.26A 3sfuC-3dr2A:
undetectable		 3sfuC-3dr2A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		4 / 8 PHE A 244
ALA A 234
ALA A 219
THR A 201
 None
 0.93A 3t3sD-3dr2A:
undetectable		 3t3sD-3dr2A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		4 / 8 PHE A 244
ALA A 234
ALA A 219
THR A 201
 None
 0.97A 3t3sE-3dr2A:
undetectable		 3t3sE-3dr2A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		4 / 6 THR A 147
ASN A 134
CYH A 102
GLY A  90
 None
CA  A 707 (-3.0A)
None
None
 1.26A 3w9tE-3dr2A:
undetectable		 3w9tE-3dr2A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		4 / 4 PHE A 220
VAL A 204
ALA A 219
PHE A 244
 None
 1.29A 4f3tA-3dr2A:
undetectable		 4f3tA-3dr2A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		3 / 3 LYS A 155
PRO A 156
SER A 157
 None
 0.22A 4k50I-3dr2A:
undetectable		 4k50I-3dr2A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		4 / 8 HIS A   4
ASP A  83
ARG A  68
TRP A  53
 None
 1.17A 4uhxA-3dr2A:
undetectable		 4uhxA-3dr2A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		4 / 4 PHE A 220
VAL A 204
ALA A 219
PHE A 244
 None
 1.33A 4w5rA-3dr2A:
undetectable		 4w5rA-3dr2A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		4 / 4 PHE A 220
VAL A 204
ALA A 219
PHE A 244
 None
 1.32A 4w5tA-3dr2A:
undetectable		 4w5tA-3dr2A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		5 / 12 CYH A 261
LEU A 252
ALA A 234
VAL A 236
ILE A 217
 None
 1.14A 4x1yB-3dr2A:
undetectable		 4x1yB-3dr2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		5 / 12 CYH A 261
LEU A 252
ALA A 234
VAL A 236
ILE A 217
 None
 1.03A 4x1yD-3dr2A:
undetectable		 4x1yD-3dr2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		4 / 8 HIS A 101
LEU A  59
GLY A  71
VAL A  69
 None
 0.90A 5m8rC-3dr2A:
undetectable		 5m8rC-3dr2A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		3 / 3 SER A 280
ALA A 279
THR A 275
 None
 0.67A 5n0xB-3dr2A:
undetectable		 5n0xB-3dr2A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		5 / 9 ASP A 242
ALA A 234
ILE A 217
GLY A 239
SER A 255
 CA  A 707 (-3.2A)
None
None
None
None
 1.30A 6awoA-3dr2A:
undetectable		 6awoA-3dr2A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3dr2 EXPORTED
GLUCONOLACTONASE
(Xanthomonas
campestris) 		5 / 9 ASP A 242
ALA A 234
ILE A 217
GLY A 239
SER A 255
 CA  A 707 (-3.2A)
None
None
None
None
 1.30A 6awqA-3dr2A:
undetectable		 6awqA-3dr2A:
18.51