SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dr5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 3dr5 PUTATIVE
O-METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 8 LEU A  45
ALA A  60
ILE A  63
ILE A  74
 None
 0.69A 1d4yB-3dr5A:
undetectable		 1d4yB-3dr5A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 3dr5 PUTATIVE
O-METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 ILE A 190
ASP A 185
ILE A 193
ALA A 196
THR A 208
 None
 1.09A 1kijB-3dr5A:
undetectable		 1kijB-3dr5A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 3dr5 PUTATIVE
O-METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 11 LEU A  69
THR A  64
PRO A  65
ALA A  66
VAL A  70
 None
 1.00A 1rv7A-3dr5A:
undetectable
1rv7B-3dr5A:
undetectable		 1rv7A-3dr5A:
15.74
1rv7B-3dr5A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dr5 PUTATIVE
O-METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 11 GLY A  77
THR A  52
GLY A  54
THR A  82
ALA A  60
 None
 1.04A 1utdP-3dr5A:
undetectable
1utdQ-3dr5A:
undetectable		 1utdP-3dr5A:
16.98
1utdQ-3dr5A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AW1_A_COXA264_1
(CARBONIC ANHYDRASE
II)		 3dr5 PUTATIVE
O-METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 VAL A 209
LEU A  48
VAL A 160
LEU A  44
THR A  41
 None
 0.91A 2aw1A-3dr5A:
undetectable		 2aw1A-3dr5A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3dr5 PUTATIVE
O-METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A  59
ASN A  81
ARG A 110
ALA A  60
ALA A  62
 None
 1.24A 2br4B-3dr5A:
11.1		 2br4B-3dr5A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 3dr5 PUTATIVE
O-METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 MET A 122
LEU A 145
LEU A 132
LEU A 159
VAL A 209
 None
 1.21A 2c12C-3dr5A:
undetectable		 2c12C-3dr5A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 3dr5 PUTATIVE
O-METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 8 VAL A 209
VAL A 160
LEU A  44
THR A  41
 None
 0.68A 2gehA-3dr5A:
undetectable		 2gehA-3dr5A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3dr5 PUTATIVE
O-METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 PHE A 134
TYR A  73
VAL A 160
ALA A  25
ALA A  29
 None
 1.33A 2x2nC-3dr5A:
undetectable		 2x2nC-3dr5A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 3dr5 PUTATIVE
O-METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 LEU A  45
ASP A  38
LEU A 201
LEU A 207
GLY A 206
 None
 1.42A 3glqA-3dr5A:
5.7		 3glqA-3dr5A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 3dr5 PUTATIVE
O-METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		6 / 12 VAL A 160
LEU A  75
LEU A  45
GLY A  59
ALA A  60
LEU A 132
 None
 1.43A 3pghC-3dr5A:
undetectable		 3pghC-3dr5A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 3dr5 PUTATIVE
O-METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 8 PHE A 101
ALA A  25
ALA A  66
THR A  64
 None
 0.93A 3t3sD-3dr5A:
undetectable		 3t3sD-3dr5A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 3dr5 PUTATIVE
O-METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 7 ARG A 117
ILE A  63
LEU A 145
ASP A 141
 None
 0.81A 4mmcA-3dr5A:
undetectable		 4mmcA-3dr5A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3dr5 PUTATIVE
O-METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 VAL A 209
LEU A 201
TRP A 150
GLY A 157
LEU A  48
 None
 1.14A 5jvzB-3dr5A:
undetectable		 5jvzB-3dr5A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_F_EZLF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 3dr5 PUTATIVE
O-METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 8 VAL A 209
VAL A 160
LEU A  44
THR A  41
 None
 0.70A 5tt3F-3dr5A:
undetectable		 5tt3F-3dr5A:
19.03