SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dr8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3dr8 YNCA
(Salmonella
enterica) 		5 / 10 SER A 122
ASN A 124
ILE A 120
GLY A 119
GLY A 146
 None
ACO  A1423 (-3.3A)
ACO  A1423 ( 4.3A)
ACT  A1428 (-3.4A)
None
 1.17A 1mehA-3dr8A:
undetectable		 1mehA-3dr8A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dr8 YNCA
(Salmonella
enterica) 		5 / 11 GLY A  64
VAL A  62
GLU A  57
ILE A  17
ARG A 103
 None
 1.37A 1vhwA-3dr8A:
undetectable
1vhwD-3dr8A:
undetectable		 1vhwA-3dr8A:
20.82
1vhwD-3dr8A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dr8 YNCA
(Salmonella
enterica) 		5 / 11 GLY A  64
VAL A  62
GLU A  57
ILE A  17
ARG A 103
 None
 1.37A 1vhwC-3dr8A:
undetectable
1vhwE-3dr8A:
undetectable		 1vhwC-3dr8A:
20.82
1vhwE-3dr8A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dr8 YNCA
(Salmonella
enterica) 		5 / 11 ARG A 103
GLY A  64
VAL A  62
GLU A  57
ILE A  17
 None
 1.37A 1vhwA-3dr8A:
undetectable
1vhwD-3dr8A:
undetectable		 1vhwA-3dr8A:
20.82
1vhwD-3dr8A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dr8 YNCA
(Salmonella
enterica) 		5 / 11 ARG A 103
GLY A  64
VAL A  62
GLU A  57
ILE A  17
 None
 1.38A 1vhwC-3dr8A:
undetectable
1vhwE-3dr8A:
undetectable		 1vhwC-3dr8A:
20.82
1vhwE-3dr8A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 3dr8 YNCA
(Salmonella
enterica) 		4 / 5 LEU A 134
ARG A  98
ILE A   3
ARG A 103
 None
 1.14A 3ticA-3dr8A:
undetectable		 3ticA-3dr8A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 3dr8 YNCA
(Salmonella
enterica) 		4 / 5 LEU A 162
ASP A 163
LEU A 160
THR A  80
 None
 1.13A 4wozF-3dr8A:
undetectable
4wozH-3dr8A:
undetectable		 4wozF-3dr8A:
22.37
4wozH-3dr8A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3dr8 YNCA
(Salmonella
enterica) 		4 / 7 VAL A 115
PHE A 136
HIS A 131
GLU A  82
 None
None
ACO  A1423 ( 4.5A)
ACT  A1429 (-2.8A)
 1.43A 5ad9A-3dr8A:
undetectable
5ad9B-3dr8A:
undetectable		 5ad9A-3dr8A:
16.86
5ad9B-3dr8A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3dr8 YNCA
(Salmonella
enterica) 		4 / 7 HIS A  83
HIS A 131
LEU A 134
SER A 127
 ACO  A1423 (-4.3A)
ACO  A1423 ( 4.5A)
None
ACO  A1423 (-3.4A)
 0.99A 5m8rA-3dr8A:
undetectable		 5m8rA-3dr8A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3dr8 YNCA
(Salmonella
enterica) 		4 / 8 HIS A  83
HIS A 131
LEU A 134
SER A 127
 ACO  A1423 (-4.3A)
ACO  A1423 ( 4.5A)
None
ACO  A1423 (-3.4A)
 0.99A 5m8rB-3dr8A:
undetectable		 5m8rB-3dr8A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3dr8 YNCA
(Salmonella
enterica) 		4 / 8 HIS A  83
HIS A 131
LEU A 134
SER A 127
 ACO  A1423 (-4.3A)
ACO  A1423 ( 4.5A)
None
ACO  A1423 (-3.4A)
 0.99A 5m8rD-3dr8A:
undetectable		 5m8rD-3dr8A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 3dr8 YNCA
(Salmonella
enterica) 		4 / 7 GLY A 135
PHE A 136
HIS A 132
VAL A 138
 None
None
None
CL  A1431 (-4.0A)
 1.00A 6hu9S-3dr8A:
undetectable
6hu9q-3dr8A:
undetectable		 6hu9S-3dr8A:
19.84
6hu9q-3dr8A:
26.09