SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dra'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
(Candida
albicans) 		4 / 6 LEU A 166
GLU A 204
THR A 198
LEU A 189
 None
 1.13A 1etb2-3draA:
undetectable		 1etb2-3draA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans) 		5 / 11 LEU B 367
LEU B   4
HIS B   9
LEU B 326
ALA B 353
 None
 1.03A 1h9zA-3draB:
undetectable		 1h9zA-3draB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans) 		5 / 11 LEU B 367
LEU B   4
HIS B   9
LEU B 326
ALA B 353
 None
 1.02A 1ha2A-3draB:
undetectable		 1ha2A-3draB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans) 		4 / 6 ALA B  33
LEU B  32
ILE B  35
CYH B  16
 None
 1.01A 1sbrA-3draB:
undetectable
1sbrB-3draB:
undetectable		 1sbrA-3draB:
16.93
1sbrB-3draB:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans) 		3 / 3 LEU B 101
LEU B 104
SER B 109
 None
 0.66A 1tlmA-3draB:
undetectable		 1tlmA-3draB:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_A_4AXA605_1
(ALANINE RACEMASE)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans) 		4 / 8 PHE B 384
TYR B 390
MET B 172
TYR B 111
 None
 1.42A 1xqlA-3draB:
undetectable
1xqlB-3draB:
undetectable		 1xqlA-3draB:
20.26
1xqlB-3draB:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_B_4AXB505_1
(ALANINE RACEMASE)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans) 		4 / 8 TYR B 111
PHE B 384
TYR B 390
MET B 172
 None
 1.42A 1xqlA-3draB:
undetectable
1xqlB-3draB:
undetectable		 1xqlA-3draB:
20.26
1xqlB-3draB:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans) 		4 / 5 ILE B  35
SER B  95
LEU B  32
ASN B 103
 None
 1.11A 1y0xX-3draB:
undetectable		 1y0xX-3draB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans) 		4 / 6 TYR B 151
PHE B  76
SER B  96
ARG B  77
 None
 1.28A 2a3cA-3draB:
undetectable		 2a3cA-3draB:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans) 		4 / 6 TYR B 151
PHE B  76
SER B  96
ARG B  77
 None
 1.28A 2a3cB-3draB:
undetectable		 2a3cB-3draB:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans) 		5 / 10 LEU B 367
LEU B   4
HIS B   9
LEU B 326
ALA B 353
 None
 1.09A 2bxeB-3draB:
undetectable		 2bxeB-3draB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans) 		4 / 6 LEU B  98
ASN B 371
GLN B  43
PHE B  99
 None
 1.24A 2jn3A-3draB:
undetectable		 2jn3A-3draB:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KQE_A_ADNA1002_1
(APRATAXIN AND
PNK-LIKE FACTOR)		 3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
(Candida
albicans) 		4 / 5 TYR A   8
SER A   4
TYR A   6
ARG A  51
 None
 1.43A 2kqeA-3draA:
0.0		 2kqeA-3draA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
(Candida
albicans) 		4 / 7 ILE A 132
ARG A 128
PHE A 124
ASP A 125
 None
None
None
B3P  A 307 (-3.0A)
 0.98A 2qebA-3draA:
undetectable		 2qebA-3draA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
(Candida
albicans) 		4 / 7 ILE A 132
ARG A 128
PHE A 124
ASP A 125
 None
None
None
B3P  A 307 (-3.0A)
 1.02A 2qebB-3draA:
undetectable		 2qebB-3draA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans) 		5 / 12 LEU B 354
LEU B 357
PHE B 337
ILE B   6
ALA B 366
 None
 1.21A 2v0mC-3draB:
undetectable		 2v0mC-3draB:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
(Candida
albicans) 		5 / 9 LEU A 245
LEU A 250
ALA A 260
LEU A 261
ALA A 265
 None
 1.14A 2vcvH-3draA:
1.6		 2vcvH-3draA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
(Candida
albicans) 		5 / 9 LEU A 245
LEU A 250
ALA A 260
LEU A 261
ALA A 265
 None
 1.19A 2vcvI-3draA:
1.8		 2vcvI-3draA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans) 		4 / 5 TYR B  36
ILE B 376
LEU B 171
LEU B 167
 None
 1.15A 2zb7A-3draB:
undetectable		 2zb7A-3draB:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans) 		4 / 8 LEU B   4
GLN B   3
PHE B 365
LEU B 357
 None
 0.96A 3asoC-3draB:
undetectable
3asoJ-3draB:
undetectable		 3asoC-3draB:
18.70
3asoJ-3draB:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FGR_B_ACTB21_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans) 		4 / 4 ARG B 278
ASP B 294
ASP B 340
PRO B 341
 None
ZN  B 391 (-2.0A)
None
None
 1.20A 3fgrB-3draB:
undetectable		 3fgrB-3draB:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans) 		4 / 7 GLY B 136
ASP B 192
ILE B 191
GLN B 153
 None
 0.86A 3fi0E-3draB:
undetectable		 3fi0E-3draB:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
(Candida
albicans) 		3 / 3 GLU A  94
LEU A  97
ASP A  98
 None
 0.26A 3ko0A-3draA:
undetectable		 3ko0A-3draA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
(Candida
albicans) 		3 / 3 GLU A  94
LEU A  97
ASP A  98
 None
 0.20A 3ko0T-3draA:
undetectable		 3ko0T-3draA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
(Candida
albicans) 		4 / 5 LEU A 189
ARG A 232
ILE A 229
PHE A 191
 None
 1.30A 3ln1D-3draA:
undetectable		 3ln1D-3draA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans;
Candida
albicans) 		6 / 12 LEU B  17
ILE A  23
CYH A  24
ILE B  34
ILE B  62
LEU B 107
 None
 1.28A 3uj6A-3draB:
undetectable		 3uj6A-3draB:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans;
Candida
albicans) 		4 / 7 SER A 221
ASN B 290
GLN A 218
ASN A 224
 None
 1.43A 4kcnB-3draA:
undetectable		 4kcnB-3draA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans) 		3 / 3 ARG B 339
HIS B 349
SER B 343
 GRG  B1721 (-3.7A)
ZN  B 391 (-3.3A)
None
 0.93A 4mjwA-3draB:
undetectable
4mjwB-3draB:
undetectable		 4mjwA-3draB:
20.39
4mjwB-3draB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans) 		3 / 3 SER B 343
ARG B 339
HIS B 349
 None
GRG  B1721 (-3.7A)
ZN  B 391 (-3.3A)
 0.95A 4mjwA-3draB:
undetectable
4mjwB-3draB:
undetectable		 4mjwA-3draB:
20.39
4mjwB-3draB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
(Candida
albicans) 		4 / 8 TRP A 296
SER A 258
HIS B 249
ILE A 291
 None
 1.33A 4ms4A-3draA:
undetectable		 4ms4A-3draA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans) 		4 / 5 TYR B 174
LEU B 166
ASP B 192
VAL B 139
 None
 1.14A 4nkvA-3draB:
undetectable		 4nkvA-3draB:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
(Candida
albicans) 		4 / 5 TYR A   6
LYS A   5
LEU A  58
GLU A  57
 None
 1.45A 4olaA-3draA:
undetectable		 4olaA-3draA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans) 		3 / 3 ASP B 175
HIS B 170
LYS B 173
 None
 0.90A 4qzuD-3draB:
undetectable		 4qzuD-3draB:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans;
Candida
albicans) 		5 / 12 PHE A 259
GLU A 262
ARG A 292
SER B 293
GLY B 283
 None
 1.35A 4ydqB-3draA:
undetectable		 4ydqB-3draA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans) 		4 / 7 ILE B 200
LEU B 159
GLY B 137
LYS B 135
 None
 0.98A 4z69A-3draB:
undetectable		 4z69A-3draB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans) 		4 / 7 LEU B   4
GLN B   3
PHE B 365
LEU B 357
 None
 0.96A 5b1aP-3draB:
undetectable
5b1aW-3draB:
undetectable		 5b1aP-3draB:
18.70
5b1aW-3draB:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans) 		4 / 7 LEU B   4
GLN B   3
PHE B 365
LEU B 357
 None
 0.96A 5b3sC-3draB:
undetectable
5b3sJ-3draB:
undetectable		 5b3sC-3draB:
18.70
5b3sJ-3draB:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans) 		4 / 7 LEU B   4
GLN B   3
PHE B 365
LEU B 357
 None
 0.94A 5b3sP-3draB:
undetectable		 5b3sP-3draB:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans) 		3 / 3 ALA B 100
ASN B 103
LEU B 104
 None
 0.51A 5i1nC-3draB:
undetectable		 5i1nC-3draB:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_A_SALA505_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
(Candida
albicans) 		4 / 8 SER B  78
HIS A  66
MET A  36
THR B  85
 None
 1.37A 5u6nA-3draB:
undetectable		 5u6nA-3draB:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
(Candida
albicans) 		4 / 7 ARG A 109
TYR A 149
GLU A 129
TRP A 152
 None
 1.18A 5umwB-3draA:
undetectable
5umwE-3draA:
undetectable		 5umwB-3draA:
12.42
5umwE-3draA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans) 		5 / 12 LEU B 367
LEU B   4
HIS B   9
LEU B 326
ALA B 353
 None
 1.13A 5v0vA-3draB:
undetectable		 5v0vA-3draB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans) 		4 / 7 LEU B   4
GLN B   3
PHE B 365
LEU B 357
 None
 0.95A 5z84C-3draB:
undetectable
5z84J-3draB:
undetectable		 5z84C-3draB:
18.70
5z84J-3draB:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans;
Candida
albicans) 		4 / 5 ASP B  28
ILE A  23
PHE B  61
TYR B  81
 None
 1.06A 6a93B-3draB:
undetectable		 6a93B-3draB:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B50_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)		 3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT
(Candida
albicans;
Candida
albicans) 		5 / 12 PRO B 255
LEU B 258
VAL B 252
PHE A 259
SER A 258
 None
 1.33A 6b50A-3draB:
undetectable		 6b50A-3draB:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
(Candida
albicans) 		4 / 6 ILE A  76
TYR A  72
LEU A  42
ARG A  51
 None
 1.20A 6f6jA-3draA:
undetectable		 6f6jA-3draA:
undetectable