SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3drk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA
(Lactococcus
lactis) 		4 / 8 ALA A 426
ASP A 467
ILE A 468
ILE A 336
 None
 0.87A 1rg9B-3drkA:
undetectable		 1rg9B-3drkA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA
(Lactococcus
lactis) 		4 / 8 ALA A 426
ASP A 467
ILE A 468
ILE A 336
 None
 0.88A 1rg9A-3drkA:
undetectable		 1rg9A-3drkA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA
(Lactococcus
lactis) 		4 / 8 ALA A 426
ASP A 467
ILE A 468
ILE A 336
 None
 0.88A 1rg9D-3drkA:
undetectable		 1rg9D-3drkA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA
(Lactococcus
lactis) 		4 / 8 ALA A 426
ASP A 467
ILE A 468
ILE A 336
 None
 0.90A 1rg9C-3drkA:
undetectable		 1rg9C-3drkA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA
(Lactococcus
lactis) 		3 / 3 THR A 216
THR A 214
PRO A 212
 None
 0.80A 209dC-3drkA:
undetectable		 209dC-3drkA:
1.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA
(Lactococcus
lactis) 		3 / 3 PRO A 218
THR A 214
PRO A 212
 None
 0.72A 2d55C-3drkA:
undetectable		 2d55C-3drkA:
1.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA
(Lactococcus
lactis) 		5 / 12 GLY A 245
LEU A 102
GLU A 113
VAL A 114
SER A 112
 None
 1.34A 2vqyA-3drkA:
undetectable		 2vqyA-3drkA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA
(Lactococcus
lactis) 		3 / 3 LYS A 217
LYS A 213
PRO A 212
 None
 0.79A 4dv1L-3drkA:
undetectable		 4dv1L-3drkA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA
(Lactococcus
lactis) 		3 / 3 GLY A  64
SER A  63
TRP A  49
 None
 0.89A 4e7cD-3drkA:
undetectable		 4e7cD-3drkA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA
(Lactococcus
lactis) 		4 / 8 ALA A 426
ASP A 467
ILE A 468
ILE A 336
 None
 0.88A 4kttD-3drkA:
undetectable		 4kttD-3drkA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA
(Lactococcus
lactis) 		3 / 3 SER A 303
TYR A 301
ASP A 346
 None
 0.73A 4rp8C-3drkA:
undetectable		 4rp8C-3drkA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA
(Lactococcus
lactis) 		5 / 12 TYR A 119
ALA A  98
VAL A  89
SER A 477
LEU A 146
 None
 1.03A 5hv1A-3drkA:
undetectable		 5hv1A-3drkA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA
(Lactococcus
lactis) 		4 / 4 ASN A 540
ILE A 336
TYR A 413
PHE A 493
 None
 1.42A 5igvA-3drkA:
undetectable		 5igvA-3drkA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA
(Lactococcus
lactis) 		4 / 7 LEU A 387
ILE A 468
MET A 305
TRP A 433
 None
 1.28A 5ljcA-3drkA:
undetectable		 5ljcA-3drkA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA
(Lactococcus
lactis) 		3 / 3 TYR A 413
SER A 441
TRP A 433
 None
 1.05A 5n8jA-3drkA:
undetectable		 5n8jA-3drkA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA
(Lactococcus
lactis) 		3 / 3 TYR A 413
SER A 441
TRP A 433
 None
 1.07A 5n8jD-3drkA:
undetectable		 5n8jD-3drkA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_G_6ELG501_0
(PROTEIN CEREBLON)		 3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA
(Lactococcus
lactis) 		4 / 8 HIS A 456
TRP A 453
PHE A 450
HIS A 495
 None
 1.42A 5yj1G-3drkA:
undetectable
5yj1Y-3drkA:
undetectable		 5yj1G-3drkA:
11.19
5yj1Y-3drkA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_A_GM4A301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA
(Lactococcus
lactis) 		5 / 11 ALA A 384
TYR A 307
LEU A 327
TYR A 376
ALA A 339
 None
 1.28A 6dk1A-3drkA:
0.0		 6dk1A-3drkA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA
(Lactococcus
lactis) 		5 / 11 ALA A 384
TYR A 307
LEU A 327
TYR A 376
ALA A 339
 None
 1.30A 6dk1C-3drkA:
undetectable		 6dk1C-3drkA:
16.50