SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3drx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AX9_A_SALA1341_1 (XANTHINE DEHYDROGENASE/OXIDAS E)	3drx	BTB/POZ DOMAIN-CONTAINING PROTEIN KCTD5 (Homo sapiens)	4 / 8	LEU A 70 ARG A 107 THR A 57 VAL A 46	None	1.02A	3ax9A-3drxA: undetectable	3ax9A-3drxA: 9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RGL_A_GLYA301_0 (GLYCYL-TRNA SYNTHETASE ALPHA SUBUNIT)	3drx	BTB/POZ DOMAIN-CONTAINING PROTEIN KCTD5 (Homo sapiens)	4 / 8	ALA A 89 GLY A 88 THR A 87 GLU A 86	None	0.65A	3rglA-3drxA: undetectable	3rglA-3drxA: 20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M2X_A_TMQA202_1 (DIHYDROFOLATE REDUCTASE)	3drx	BTB/POZ DOMAIN-CONTAINING PROTEIN KCTD5 (Homo sapiens)	5 / 12	ASP A 65 ILE A 131 PHE A 99 LEU A 62 LEU A 48	None	0.98A	4m2xA-3drxA: undetectable	4m2xA-3drxA: 24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EU9_B_REAB601_1 (RETINOIC ACID RECEPTOR)	3drx	BTB/POZ DOMAIN-CONTAINING PROTEIN KCTD5 (Homo sapiens)	5 / 10	VAL A 102 LEU A 103 LEU A 117 PHE A 55 VAL A 122	None	1.23A	6eu9B-3drxA: undetectable	6eu9B-3drxA: 20.32

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3AX9_A_SALA1341_1","XANTHINE DEHYDROGENASE\/OXIDASE","3drx","BTB\/POZ DOMAIN-CONTAINING PROTEIN KCTD5","Homo sapiens",4,"LEU A  70;ARG A 107;THR A  57;VAL A  46","None","1.02A","3ax9A-3drxA:undetectable","3ax9A-3drxA:9.97"],["3RGL_A_GLYA301_0","GLYCYL-TRNA SYNTHETASE ALPHA SUBUNIT","3drx","BTB\/POZ DOMAIN-CONTAINING PROTEIN KCTD5","Homo sapiens",4,"ALA A  89;GLY A  88;THR A  87;GLU A  86","None","0.65A","3rglA-3drxA:undetectable","3rglA-3drxA:20.38"],["4M2X_A_TMQA202_1","DIHYDROFOLATE REDUCTASE","3drx","BTB\/POZ DOMAIN-CONTAINING PROTEIN KCTD5","Homo sapiens",5,"ASP A  65;ILE A 131;PHE A  99;LEU A  62;LEU A  48","None","0.98A","4m2xA-3drxA:undetectable","4m2xA-3drxA:24.64"],["6EU9_B_REAB601_1","RETINOIC ACID RECEPTOR","3drx","BTB\/POZ DOMAIN-CONTAINING PROTEIN KCTD5","Homo sapiens",5,"VAL A 102;LEU A 103;LEU A 117;PHE A  55;VAL A 122","None","1.23A","6eu9B-3drxA:undetectable","6eu9B-3drxA:20.32"]]