SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dsq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3dsq PYRROLYSYL-TRNA
SYNTHETASE
(Desulfitobacteri
um
hafniense) 		6 / 12 GLY A 256
GLY A 254
VAL A 223
LEU A 230
LEU A 257
LEU A  73
 None
 1.47A 3cjtO-3dsqA:
undetectable		 3cjtO-3dsqA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 3dsq PYRROLYSYL-TRNA
SYNTHETASE
(Desulfitobacteri
um
hafniense) 		5 / 12 LEU A 257
ARG A 259
ALA A 231
PHE A 255
LEU A 199
 None
 1.36A 3gwuA-3dsqA:
undetectable		 3gwuA-3dsqA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_A_PARA500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3dsq PYRROLYSYL-TRNA
SYNTHETASE
(Desulfitobacteri
um
hafniense) 		5 / 10 PHE A 239
THR A 220
SER A 214
GLU A 229
ASP A 222
 None
 1.49A 4qb9A-3dsqA:
0.0		 4qb9A-3dsqA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3dsq PYRROLYSYL-TRNA
SYNTHETASE
(Desulfitobacteri
um
hafniense) 		5 / 12 PHE A 239
THR A 220
SER A 214
GLU A 229
ASP A 222
 None
 1.40A 4qb9E-3dsqA:
undetectable		 4qb9E-3dsqA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 3dsq PYRROLYSYL-TRNA
SYNTHETASE
(Desulfitobacteri
um
hafniense) 		3 / 3 ARG A  44
ASP A  43
ARG A  42
 None
 0.61A 4wq4B-3dsqA:
undetectable		 4wq4B-3dsqA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 3dsq PYRROLYSYL-TRNA
SYNTHETASE
(Desulfitobacteri
um
hafniense) 		4 / 8 ILE A 263
ARG A 259
VAL A 223
ASP A 227
 None
 1.03A 5vlmF-3dsqA:
undetectable		 5vlmF-3dsqA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 3dsq PYRROLYSYL-TRNA
SYNTHETASE
(Desulfitobacteri
um
hafniense) 		5 / 12 TYR A 217
ILE A 108
LEU A 240
GLY A 233
ALA A 234
 None
 0.94A 5zwrA-3dsqA:
undetectable		 5zwrA-3dsqA:
20.63