SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dty'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AZM_A_AZMA262_1
(CARBONIC ANHYDRASE I)		 3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 8 PHE A  39
HIS A  29
THR A 141
TRP A 333
 None
 1.00A 1azmA-3dtyA:
undetectable		 1azmA-3dtyA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 6 PHE A 294
ARG A 279
ALA A 280
ILE A 157
 None
 0.90A 1oniH-3dtyA:
1.4
1oniI-3dtyA:
undetectable		 1oniH-3dtyA:
16.15
1oniI-3dtyA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_1
(VITAMIN D3 RECEPTOR)		 3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 5 SER A 200
ARG A 230
HIS A 174
HIS A 177
 None
 1.40A 1s19A-3dtyA:
0.0		 1s19A-3dtyA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 LEU A 336
HIS A  29
ILE A  28
 None
 0.58A 1s9pB-3dtyA:
undetectable		 1s9pB-3dtyA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 7 VAL A 258
SER A 260
PHE A 172
HIS A 209
 None
 1.11A 2f78B-3dtyA:
undetectable		 2f78B-3dtyA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 11 GLY A  19
ILE A 100
ALA A 103
VAL A  88
ILE A  85
 None
 1.08A 2nnhA-3dtyA:
undetectable		 2nnhA-3dtyA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 LEU A 292
ILE A 303
LEU A 304
ALA A 153
ARG A 274
 None
 1.32A 2qo6A-3dtyA:
0.7		 2qo6A-3dtyA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 GLY A 139
LEU A 355
VAL A 358
HIS A 132
LEU A 105
 None
 1.23A 3g9eA-3dtyA:
undetectable		 3g9eA-3dtyA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 6 LEU A 329
PHE A 330
ILE A  28
PHE A  39
 None
 0.96A 3ko0B-3dtyA:
undetectable		 3ko0B-3dtyA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 7 TYR A 338
GLN A 148
GLU A 151
ARG A   7
 None
 1.22A 3s3oA-3dtyA:
undetectable		 3s3oA-3dtyA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 GLY A 270
HIS A 269
ARG A 306
GLN A 291
GLU A 327
 None
 1.37A 3tkaA-3dtyA:
5.0		 3tkaA-3dtyA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 LEU A 105
LYS A 102
THR A 101
 None
 0.63A 4lj0A-3dtyA:
undetectable		 4lj0A-3dtyA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 7 GLU A 215
GLU A 368
TYR A 389
LEU A 226
 None
 1.17A 4twdF-3dtyA:
undetectable
4twdJ-3dtyA:
undetectable		 4twdF-3dtyA:
21.01
4twdJ-3dtyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 4 ALA A 365
VAL A 370
GLY A 204
THR A 208
 None
 1.06A 4ubeA-3dtyA:
3.4		 4ubeA-3dtyA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 GLY A 146
ILE A 150
GLN A 271
HIS A 147
TRP A 333
 None
 1.48A 4xucA-3dtyA:
4.8		 4xucA-3dtyA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 GLY A 146
ILE A 150
GLN A 271
HIS A 147
TRP A 333
 None
 1.47A 4xudA-3dtyA:
4.7		 4xudA-3dtyA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 7 CYH A 113
LYS A 115
LEU A 117
GLY A 369
GLY A 366
 None
 1.14A 5a06A-3dtyA:
33.5		 5a06A-3dtyA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 7 CYH A 113
LYS A 115
LEU A 117
GLY A 369
GLY A 366
 None
 1.13A 5a06C-3dtyA:
12.0		 5a06C-3dtyA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 6 CYH A 113
LYS A 115
GLY A 369
GLY A 366
 None
 1.03A 5a06D-3dtyA:
33.2		 5a06D-3dtyA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 7 CYH A 113
LYS A 115
LEU A 117
GLY A 369
GLY A 366
 None
 1.14A 5a06E-3dtyA:
18.2		 5a06E-3dtyA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 7 CYH A 113
LYS A 115
LEU A 117
GLY A 369
GLY A 366
 None
 1.14A 5a06F-3dtyA:
18.3		 5a06F-3dtyA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DL9_A_ACTA214_0
(LYSOZYME C)		 3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 5 GLU A  78
ASP A  83
VAL A  42
ALA A  43
 None
 1.50A 5dl9A-3dtyA:
undetectable		 5dl9A-3dtyA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 SER A 261
TRP A 372
VAL A 206
GLY A 204
SER A 200
 None
 1.11A 5kirB-3dtyA:
undetectable		 5kirB-3dtyA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 ILE A 363
LEU A 355
ALA A 145
GLY A 143
TYR A 142
 None
 1.13A 5uxdB-3dtyA:
undetectable		 5uxdB-3dtyA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 LEU A 117
PHE A  75
ILE A 363
THR A 347
GLY A 108
 None
 1.08A 5veuB-3dtyA:
undetectable		 5veuB-3dtyA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 5 HIS A  97
ASP A 205
GLY A 204
ASN A  94
 None
 1.25A 5x7pB-3dtyA:
2.2		 5x7pB-3dtyA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 PHE A  46
ARG A  30
ALA A  91
 None
 0.88A 6ecfB-3dtyA:
4.0		 6ecfB-3dtyA:
23.77