SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dtz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 3dtz PUTATIVE CHLORITE
DISMUTASE TA0507
(Thermoplasma
acidophilum) 		5 / 12 GLU A 109
ILE A   4
GLY A  43
MET A  71
ALA A  74
 None
 1.33A 1hvyB-3dtzA:
undetectable		 1hvyB-3dtzA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 3dtz PUTATIVE CHLORITE
DISMUTASE TA0507
(Thermoplasma
acidophilum) 		4 / 7 LEU A 133
ILE A 202
MET A 125
MET A 143
 None
 1.23A 1kglA-3dtzA:
undetectable		 1kglA-3dtzA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 3dtz PUTATIVE CHLORITE
DISMUTASE TA0507
(Thermoplasma
acidophilum) 		5 / 12 SER A  88
LEU A   9
VAL A  59
PHE A  61
ILE A  34
 None
 1.25A 1uobA-3dtzA:
undetectable		 1uobA-3dtzA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)		 3dtz PUTATIVE CHLORITE
DISMUTASE TA0507
(Thermoplasma
acidophilum) 		5 / 12 ASN A  46
TYR A 162
TYR A 101
GLU A 179
ARG A 160
 None
 1.48A 2f0zA-3dtzA:
undetectable		 2f0zA-3dtzA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 3dtz PUTATIVE CHLORITE
DISMUTASE TA0507
(Thermoplasma
acidophilum) 		4 / 6 MET A 143
ILE A 202
PRO A 100
SER A  99
 None
 1.30A 2qd3B-3dtzA:
undetectable		 2qd3B-3dtzA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRI_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 3dtz PUTATIVE CHLORITE
DISMUTASE TA0507
(Thermoplasma
acidophilum) 		5 / 10 TYR A 178
VAL A 121
TYR A 123
TYR A  53
ILE A 183
 None
 1.08A 3vriA-3dtzA:
undetectable
3vriC-3dtzA:
undetectable		 3vriA-3dtzA:
20.34
3vriC-3dtzA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 3dtz PUTATIVE CHLORITE
DISMUTASE TA0507
(Thermoplasma
acidophilum) 		5 / 12 TYR A 178
VAL A 121
TYR A 123
TYR A  53
ILE A 183
 None
 1.10A 3vrjA-3dtzA:
undetectable
3vrjC-3dtzA:
undetectable		 3vrjA-3dtzA:
20.34
3vrjC-3dtzA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 3dtz PUTATIVE CHLORITE
DISMUTASE TA0507
(Thermoplasma
acidophilum) 		4 / 6 ASN A  46
TYR A 101
TYR A 162
LEU A 108
 None
 1.36A 4f8yA-3dtzA:
undetectable
4f8yB-3dtzA:
undetectable		 4f8yA-3dtzA:
22.00
4f8yB-3dtzA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3dtz PUTATIVE CHLORITE
DISMUTASE TA0507
(Thermoplasma
acidophilum) 		3 / 3 SER A 161
TYR A 178
PRO A 100
 None
 0.94A 4kahB-3dtzA:
undetectable		 4kahB-3dtzA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3dtz PUTATIVE CHLORITE
DISMUTASE TA0507
(Thermoplasma
acidophilum) 		3 / 3 SER A 161
TYR A 178
PRO A 100
 None
 0.91A 4kbeB-3dtzA:
undetectable		 4kbeB-3dtzA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 3dtz PUTATIVE CHLORITE
DISMUTASE TA0507
(Thermoplasma
acidophilum) 		5 / 12 VAL A 175
LEU A 177
PHE A  90
SER A  10
ILE A  60
 None
 1.19A 4pd9A-3dtzA:
undetectable		 4pd9A-3dtzA:
20.05