SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3du4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		4 / 8 PHE A 264
GLY A 258
ARG A 259
LEU A 422
 None
 0.70A 1gsfC-3du4A:
undetectable		 1gsfC-3du4A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		4 / 8 TYR A 244
LEU A 247
GLU A 210
TRP A 128
 None
 1.11A 1i7zA-3du4A:
undetectable		 1i7zA-3du4A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		3 / 3 LEU A 361
HIS A 441
LYS A 437
 None
 1.03A 1y7iA-3du4A:
undetectable		 1y7iA-3du4A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		5 / 12 ALA A 328
TYR A 109
VAL A 107
GLY A 324
ILE A 289
 None
 1.36A 2dcfA-3du4A:
undetectable		 2dcfA-3du4A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		5 / 12 GLY A 279
GLY A 113
ILE A 289
ASP A 111
LEU A  96
 None
PLP  A 450 (-3.2A)
None
None
None
 0.87A 2nxeA-3du4A:
undetectable		 2nxeA-3du4A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		6 / 12 ILE A 178
ALA A 223
GLY A 225
VAL A 415
ASN A 144
PHE A 162
 None
KAP  A 451 ( 4.2A)
None
None
None
None
 1.23A 2okcA-3du4A:
undetectable		 2okcA-3du4A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		6 / 12 ILE A 178
ALA A 223
GLY A 225
VAL A 415
ASN A 144
PHE A 162
 None
KAP  A 451 ( 4.2A)
None
None
None
None
 1.26A 2okcB-3du4A:
undetectable		 2okcB-3du4A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		4 / 7 ALA A  89
THR A  90
ALA A  93
ARG A 106
 None
 0.88A 2ql8A-3du4A:
undetectable
2ql8B-3du4A:
undetectable		 2ql8A-3du4A:
15.45
2ql8B-3du4A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		3 / 3 PRO A 230
MET A 229
TYR A 233
 None
 1.02A 4qa0B-3du4A:
3.5		 4qa0B-3du4A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		3 / 3 PRO A 230
MET A 229
TYR A 233
 None
 1.03A 4qa0A-3du4A:
2.9		 4qa0A-3du4A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		3 / 3 PRO A 230
MET A 229
TYR A 233
 None
 1.03A 4qa2B-3du4A:
undetectable		 4qa2B-3du4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		4 / 7 GLU A 217
ARG A 368
GLY A 225
GLY A 222
 PLP  A 450 (-4.2A)
None
None
None
 0.90A 4rdxA-3du4A:
undetectable		 4rdxA-3du4A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		5 / 9 ALA A 114
ALA A 116
ALA A 120
SER A 215
ALA A 153
 PLP  A 450 (-3.5A)
None
None
None
None
 1.22A 4twdA-3du4A:
undetectable
4twdB-3du4A:
undetectable
4twdC-3du4A:
undetectable
4twdD-3du4A:
undetectable
4twdE-3du4A:
undetectable		 4twdA-3du4A:
21.63
4twdB-3du4A:
21.63
4twdC-3du4A:
21.63
4twdD-3du4A:
21.63
4twdE-3du4A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		5 / 8 ALA A 120
SER A 215
ALA A 153
ALA A 114
ALA A 116
 None
None
None
PLP  A 450 (-3.5A)
None
 1.23A 4twdF-3du4A:
undetectable
4twdG-3du4A:
undetectable
4twdH-3du4A:
0.3
4twdI-3du4A:
undetectable
4twdJ-3du4A:
undetectable		 4twdF-3du4A:
21.63
4twdG-3du4A:
21.63
4twdH-3du4A:
21.63
4twdI-3du4A:
21.63
4twdJ-3du4A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		5 / 12 GLY A 157
TYR A 174
SER A 173
ILE A 159
ASN A 144
 None
 1.36A 4xueB-3du4A:
undetectable		 4xueB-3du4A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		6 / 12 GLY A 258
GLY A 256
GLY A 279
LYS A 262
GLU A 252
VAL A 344
 None
 1.46A 5e9qA-3du4A:
undetectable		 5e9qA-3du4A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		6 / 12 GLY A 258
GLY A 256
GLY A 279
LYS A 262
GLU A 252
VAL A 344
 None
 1.42A 5ec8A-3du4A:
undetectable		 5ec8A-3du4A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		6 / 12 GLY A 258
GLY A 256
GLY A 279
LYS A 262
GLU A 252
VAL A 344
 None
 1.50A 5eifA-3du4A:
undetectable		 5eifA-3du4A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		5 / 7 SER A 424
ALA A 423
GLY A  59
VAL A  57
ARG A 259
 None
 1.46A 5fpdB-3du4A:
undetectable		 5fpdB-3du4A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		4 / 7 GLY A 256
VAL A 344
ILE A 340
VAL A 341
 None
 0.81A 5ik1A-3du4A:
undetectable		 5ik1A-3du4A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		5 / 12 GLU A 217
LEU A  55
THR A 409
GLY A 225
LEU A 412
 PLP  A 450 (-4.2A)
None
None
None
None
 1.18A 5m5cB-3du4A:
undetectable		 5m5cB-3du4A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		5 / 10 GLU A 217
LEU A  55
THR A 409
GLY A 225
LEU A 412
 PLP  A 450 (-4.2A)
None
None
None
None
 1.21A 5m5cE-3du4A:
undetectable		 5m5cE-3du4A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		4 / 5 HIS A 163
ILE A 159
PHE A  17
ALA A 223
 None
None
KAP  A 451 ( 4.1A)
KAP  A 451 ( 4.2A)
 1.05A 5msdA-3du4A:
undetectable		 5msdA-3du4A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		3 / 3 LYS A 133
LEU A 247
ASP A 245
 None
 0.85A 5zv2A-3du4A:
undetectable		 5zv2A-3du4A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		3 / 3 TYR A 286
ASN A 331
LEU A  65
 None
 0.77A 6b58A-3du4A:
undetectable		 6b58A-3du4A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		5 / 12 HIS A  58
VAL A 341
MET A 276
THR A 283
GLY A 284
 None
 1.33A 6brdA-3du4A:
undetectable		 6brdA-3du4A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		4 / 4 HIS A 268
VAL A 220
LEU A 370
ALA A 265
 None
 1.24A 6d8pB-3du4A:
undetectable		 6d8pB-3du4A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		5 / 11 THR A 150
SER A 110
ALA A 290
THR A 292
ALA A 124
 None
 1.13A 6efnA-3du4A:
undetectable		 6efnA-3du4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(Bacillus
subtilis) 		3 / 3 VAL A  38
GLU A  45
ILE A  30
 None
 0.57A 6f7lB-3du4A:
undetectable		 6f7lB-3du4A:
22.49