SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dup'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC608_0
(GBAA_1210 PROTEIN)		 3dup MUTT/NUDIX FAMILY
PROTEIN
(Rhodospirillum
rubrum) 		4 / 5 GLU A 174
ARG A 106
LYS A 142
GLU A 170
 None
PO4  A 299 ( 3.3A)
PO4  A 299 (-3.1A)
None
 1.42A 3tj7C-3dupA:
undetectable		 3tj7C-3dupA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 3dup MUTT/NUDIX FAMILY
PROTEIN
(Rhodospirillum
rubrum) 		4 / 6 GLU A 225
ARG A 138
GLU A 174
GLU A 170
 None
PO4  A 299 (-2.9A)
None
None
 1.49A 4kr3A-3dupA:
undetectable		 4kr3A-3dupA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3dup MUTT/NUDIX FAMILY
PROTEIN
(Rhodospirillum
rubrum) 		4 / 6 LEU A  55
SER A  56
PHE A  46
ASP A  47
 None
 1.13A 5om3A-3dupA:
undetectable
5om3B-3dupA:
undetectable		 5om3A-3dupA:
16.00
5om3B-3dupA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 3dup MUTT/NUDIX FAMILY
PROTEIN
(Rhodospirillum
rubrum) 		3 / 3 GLU A  88
ARG A 106
TYR A  90
 None
PO4  A 299 ( 3.3A)
None
 0.56A 5trqB-3dupA:
undetectable		 5trqB-3dupA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3dup MUTT/NUDIX FAMILY
PROTEIN
(Rhodospirillum
rubrum) 		4 / 7 ALA A 154
GLY A 136
GLU A 174
ASN A 166
 None
 0.81A 5ybbB-3dupA:
undetectable		 5ybbB-3dupA:
21.58